US5429618A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thromboresistant articles
Assignee: Medtronic Inc
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Filing: 1994-03-14
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Granted: 1995-07-04
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Expires: 2014-03-14
Abstract
Abstract Articles comprised of 2-acrylamido-2-methyl propane sulfonic acid (AMPS) polymer on a blood-contacting substrate or the like are useful in medical devices in which antithrombogenic characteristics and slippery surfaces are required.
Inventors
- 👤 James R. Keogh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:55
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/062; A61L33/0076; A61L33/0088; A61L33/064
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
56 words
A method for reducing thrombosis when an article is used in contact with blood or blood products, the method comprising: providing an article having at least one exposed surface for contacting blood, applying to the surface an antithrombogentic agent of polymerized 2-acrylamido-2-methyl propane sulfonic acid (AMPS) polymer and placing the coated surface into contact with blood.
Claim 2
Independent Claim
56 words
A method for reducing thrombosis when an article is used in contact with blood or blood products, the method comprising: providing an article having at least one exposed surface for contacting blood, applying to the surface an antithrombogentic agent of polymerized 2-acrylamido-2-methyl propane sulfonic acid (AMPS) polymer and placing the coated surface into contact with blood.
Claim 3
Dependent Claim
18 words
The method of claim 1 in which the exposed surface provided on the article is a polymeric surface.
Claim 4
Dependent Claim
19 words
The method of claim 2 in which the AMPS polymer is applied by graft polymerization onto the polymeric surface.
Claim 5
Dependent Claim
20 words
The method of claim 2 in which the AMPS polymer is blended applied by blending it into the polymeric surface.
Claim 6
Dependent Claim
12 words
The method of claim 2 in which the polymeric surface is polyurethane.
Claim 7
Dependent Claim
19 words
The method of claim 1 in which the AMPS polymer is applied by dip coating onto the article surface.
Claim 8
Dependent Claim
23 words
The method of claim 1 in which the article is placed into contact with blood by implantation in a human or animal body.
Claim 9
Dependent Claim
24 words
The method of claim 1 in which the article is placed into contact with blood or blood products by flowing blood through the article.
Claim 10
Dependent Claim
14 words
The article of claim 1 in which the article is a temporary indwelling device.
Claim 11
Independent Claim
84 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) preparing an aqueous solution of 2-acrylamido-2-methylpropane sulfonic acid monomer and Ce IV ion; (b) contacting a polymeric, blood-contacting surface of the implantable article with the monomer solution for a period of time effective to provide a polymer of 2-acrylamido-2-methylpropane sulfonic acid grafted to the surface; and (c) implanting the article in the living body of a person or an animal with the grafted surface of the article in blood contact.
Claim 12
Independent Claim
84 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) preparing an aqueous solution of 2-acrylamido-2-methylpropane sulfonic acid monomer and Ce IV ion; (b) contacting a polymeric, blood-contacting surface of the implantable article with the monomer solution for a period of time effective to provide a polymer of 2-acrylamido-2-methylpropane sulfonic acid grafted to the surface; and (c) implanting the article in the living body of a person or an animal with the grafted surface of the article in blood contact.
Claim 13
Independent Claim
91 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) polymerizing 2-acrylamido-2-methylpropane sulfonic acid monomer; (b) dissolving the polymerized monomer in a solvent which is also capable of dissolving a polyurethane polymer; (c) combining the polymerized monomer solution with a polyurethane polymer; (d) forming the combined polymerized monomer and polyurethane polymer into a blood-contacting surface for the implantable article; and (e) implanting the article and blood-contacting surface in the living body of a person or an animal with the blood-contacting surface of the article in blood contact.
Claim 14
Independent Claim
91 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) polymerizing 2-acrylamido-2-methylpropane sulfonic acid monomer; (b) dissolving the polymerized monomer in a solvent which is also capable of dissolving a polyurethane polymer; (c) combining the polymerized monomer solution with a polyurethane polymer; (d) forming the combined polymerized monomer and polyurethane polymer into a blood-contacting surface for the implantable article; and (e) implanting the article and blood-contacting surface in the living body of a person or an animal with the blood-contacting surface of the article in blood contact.
Claim 15
Independent Claim
79 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) polymerizing 2-acrylamido-2-methylpropane sulfonic acid monomer; (b) dissolving the polymerized monomer in a solvent which is also capable of dissolving a polyurethane polymer; (c) applying the polymerized monomer solution to a blood-contacting polyurethane surface of the implantable article; and (d) implanting the article and blood-contacting surface in the living body of a person or an animal with the blood-contacting surface of the article in blood contact.
Claim 16
Independent Claim
79 words
A method for reducing thrombosis for an implantable article comprising the steps of: (a) polymerizing 2-acrylamido-2-methylpropane sulfonic acid monomer; (b) dissolving the polymerized monomer in a solvent which is also capable of dissolving a polyurethane polymer; (c) applying the polymerized monomer solution to a blood-contacting polyurethane surface of the implantable article; and (d) implanting the article and blood-contacting surface in the living body of a person or an animal with the blood-contacting surface of the article in blood contact.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-07-03 | 1999-01-02 | 1999-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-07-03 | 2003-01-02 | 2003-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-07-03 | 2007-01-02 | 2007-07-04 | $7700.00 | Window Closed / Lapsed |