US6201039B1
Expired / Lapsed
US
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Bone substitute composition comprising hydroxyapatite and a method of production therefor
Assignee: Penn State Research Foundation
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Filing: 1994-09-20
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Granted: 2001-03-13
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Expires: 2014-09-20
Abstract
Abstract The present invention is directed to polymineralic particles which are precursors of hydroxyapatite and a method for their production. The present invention is also directed to a synthetic bone-like composition comprising said hydroxyapatite polymineralic precursor particles of hydroxyapatite and optionally, a polymeric material capable of promoting mineralization of hydroxyapatite, which are useful for fixing prosthetic devices, useful as bone substitutes to directly fill bone defects, to provide substrates for cartilage, and to repair teeth, and methods of making such preparations. The present invention is also directed to a method of treating collagen to provide a micro-structure close to that of native bone.
Inventors
- 👤 Paul W. Brown
- 👤 Kevor S. Ten Huisen
- 👤 Roger I. Martin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:39
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/02; A61L27/12; A61L27/14; A61L27/22; A61L27/24; C; C08; C08K; C08K3/00; C08K3/32; A61F2/30; A61F2/30756; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61F2310/00365; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
83 words
A synthetic bone-like substitute kit comprising: (a) a container of polymineralic precursor particles produced by reacting a calcium source, with an acidic phosphate source having at least two protons attached to one phosphate, in a non-aqueous liquid for a time sufficient to produce polymineralic precursor particles capable of forming hydroxyapatite without additional sources of calcium or phosphate said polymineralic precursor particles having a Ca/P ratio of 1.5 to 1.67, capable of forming hydroxyapatite in the absence of additional sources of calcium and phosphate.
Claim 2
Dependent Claim
83 words
A synthetic bone-like substitute kit comprising: (a) a container of polymineralic precursor particles produced by reacting a calcium source, with an acidic phosphate source having at least two protons attached to one phosphate, in a non-aqueous liquid for a time sufficient to produce polymineralic precursor particles capable of forming hydroxyapatite without additional sources of calcium or phosphate said polymineralic precursor particles having a Ca/P ratio of 1.5 to 1.67, capable of forming hydroxyapatite in the absence of additional sources of calcium and phosphate.
Claim 3
Dependent Claim
20 words
The kit according to claim 1 further comprising a container of a polymeric material capable of promoting mineralization of hydroxyapatite.
Claim 4
Dependent Claim
24 words
The kit according to claim 1 wherein said polymineralic material is treated insoluble collagen having a pore size of from 2 to 100 μm.
Claim 5
Dependent Claim
37 words
The invention according to claim 1 wherein said calcium source is calcium oxide, calcium carbonate, calcium hydroxide, calcium hydroxide-calcium carbonate double salts, or a basic calcium phosphate having a Ca/P ratio greater than 1.67 or mixtures thereof.
Claim 6
Independent Claim
53 words
A method of treating insoluble collagen for use in a synthetic bone-like composition which comprises the steps of: (a) suspending insoluble collagen in an acidic solution to form a suspension; (b) subjecting said suspension to a mechanical action; (c) freezing said suspension; (d) thawing said frozen suspension; and (e) collecting said treated collagen.
Claim 7
Independent Claim
53 words
A method of treating insoluble collagen for use in a synthetic bone-like composition which comprises the steps of: (a) suspending insoluble collagen in an acidic solution to form a suspension; (b) subjecting said suspension to a mechanical action; (c) freezing said suspension; (d) thawing said frozen suspension; and (e) collecting said treated collagen.
Claim 8
Dependent Claim
20 words
The method according to claim 5 wherein said treated collagen has a pore size from 2 μm to 100 μm.
Claim 9
Dependent Claim
17 words
The method according to claim 5 further comprising repeating steps (c) and (d), prior to step (e).
Claim 10
Dependent Claim
14 words
The method according to claim 5 , wherein said collecting step (e) is freeze-drying.
Claim 11
Dependent Claim
13 words
Insoluble collagen produced by the process according to claims 5 or 6 .
Claim 12
Independent Claim
79 words
A method of producing polymineralic precursor particles capable of forming hydroxyapatite in the absence of additional sources of calcium and phosphate, which comprises the steps of: (a) reacting at least one calcium source, with at least one acid phosphate source having at least 2 protons attached to one phosphate, in a non-aqueous liquid for a time sufficient to form said polymineralic precursors particles and having a Ca/P ratio of 1.5 to 1.67; and (b) collecting said polymineralic precursor particles.
Claim 13
Independent Claim
79 words
A method of producing polymineralic precursor particles capable of forming hydroxyapatite in the absence of additional sources of calcium and phosphate, which comprises the steps of: (a) reacting at least one calcium source, with at least one acid phosphate source having at least 2 protons attached to one phosphate, in a non-aqueous liquid for a time sufficient to form said polymineralic precursors particles and having a Ca/P ratio of 1.5 to 1.67; and (b) collecting said polymineralic precursor particles.
Claim 14
Dependent Claim
22 words
The method according to claim 10 wherein said calcium source has an average particle size of from 1 μm to 5 μm.
Claim 15
Dependent Claim
27 words
The method according to claim 10 wherein said non-aqueous liquid is selected from the group consisting of substituted or unsubstituted liquid aliphatic hydrocarbons and liquid aromatic hydrocarbons.
Claim 16
Dependent Claim
44 words
The method according to claim 10 wherein said calcium source is selected from the group consisting of calcium oxide, calcium carbonate, calcium hydroxide, calcium hydroxide-calcium carbonate double salts, or a basic calcium phosphate having a Ca/P ratio of greater than 1.67 or mixtures thereof.
Claim 17
Dependent Claim
72 words
The method according to claim 10 wherein said acidic phosphate source having at least two protons attached to one phosphate is selected form the group consisting of phosphoric acid, H 3 PO 4 , H 3 PO 4 .½H 2 O, Ca(H 2 PO 4 ) 2 , Ca(H 2 PO 4 ) 2 .H 2 O and NH 4 H 2 (PO 4 ) 2 .nH 2 O, or mixtures thereof.
Claim 18
Dependent Claim
17 words
The method according to claim 10 wherein said collecting step (b) comprises evaporating off said non-aqueous liquid.
Claim 19
Dependent Claim
12 words
Polymineralic precursor particles produced by the process according to claim 10 .
Claim 20
Dependent Claim
13 words
A hydroxyapatite composition comprising the polymineralic precursor particles according to claim 16 .
Claim 21
Dependent Claim
18 words
The composition according to claim 17 , which completely reacts to form phase pure hydroxyapatite within 2 hours.
Claim 22
Dependent Claim
37 words
The method according to claim 8 wherein said calcium source is calcium oxide, calcium carbonate, calcium hydroxide, calcium hydroxide-calcium carbonate double salts, or a basic calcium phosphate having a Ca/P ratio greater than 1.67 or mixtures thereof.
Claim 23
Dependent Claim
19 words
The method according to claim 19 wherein said basic calcium phosphate is Ca 4 (PO 4 ) 2 O.
Claim 24
Dependent Claim
28 words
The method according to claim 8 wherein said basic calcium phosphate is Ca 4 (PO 4 ) 2 O and the non aqueous liquid is an aliphatic hydrocarbon.
Claim 25
Dependent Claim
13 words
The method according to claim 10 , wherein said non-aqueous liquid is heptane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-03-12 | 2004-09-11 | 2005-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-03-12 | 2008-09-11 | 2009-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-03-12 | 2012-09-11 | 2013-03-13 | $7700.00 | Window Closed / Lapsed |