US6110482A — Manufacture of autogenous replacement body parts

Claim 1

Independent Claim 178 words

A device for repair of a skeletal joint defect in a mammal which serves as a template to form in vivo a functional replacement skeletal joint which is long term mechanically and functionally viable, comprising plural distinct tissues, the device comprising: a) a biocompatible, biodegradable matrix defining a unitary intact structure allowing the attachment of infiltrating cells, and comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue of a joint and including bone underlying the articular surface wherein said underlying bone extends through the margin of articular cartilage into the supporting cancellous bone of said proximal or distal hemi-joint, and, having dimensions and shape conforming to the skeletal joint to be repaired; and disposed on the surface of said matrix, b) an exogenous osteogenic protein deposited on the matrix surface in an amount sufficient to induce formation of new said plural distinct tissues having dimensions and shape which conform to the skeletal joint to be repaired, thereby to permit regeneration of a functional replacement skeletal joint comprising plural distinct tissues.

Claim 2

Independent Claim 178 words

A device for repair of a skeletal joint defect in a mammal which serves as a template to form in vivo a functional replacement skeletal joint which is long term mechanically and functionally viable, comprising plural distinct tissues, the device comprising: a) a biocompatible, biodegradable matrix defining a unitary intact structure allowing the attachment of infiltrating cells, and comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue of a joint and including bone underlying the articular surface wherein said underlying bone extends through the margin of articular cartilage into the supporting cancellous bone of said proximal or distal hemi-joint, and, having dimensions and shape conforming to the skeletal joint to be repaired; and disposed on the surface of said matrix, b) an exogenous osteogenic protein deposited on the matrix surface in an amount sufficient to induce formation of new said plural distinct tissues having dimensions and shape which conform to the skeletal joint to be repaired, thereby to permit regeneration of a functional replacement skeletal joint comprising plural distinct tissues.

Claim 3

Dependent Claim 15 words

The device of claim 1 wherein said matrix comprises devitalized tissue from a mammalian donor.

Claim 4

Dependent Claim 12 words

The device of claim 1 wherein the matrix comprises dehydrated mammalian tissue.

Claim 5

Dependent Claim 29 words

The device of claim 1 wherein said non-mineralized tissue is selected from the group consisting of articular cartilage, ligament, tendon, joint capsule, menisci, intervertebral discs, and synovial membrane tissue.

Claim 6

Dependent Claim 15 words

The device of claim 1 wherein said skeletal joint defines a synovial or articulating joint.

Claim 7

Dependent Claim 14 words

The device of claim 1 wherein said matrix defines a devitalized skeletal joint structure.

Claim 8

Independent Claim 87 words

A device for implantation in a mammal which serves as a template for forming in vivo articular cartilage replacement tissue which is long term mechanically and functionally viable, in a skeletal, joint the device comprising: exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including articular cartilage, said tissues defining a unitary structure which allows the attachment of infiltrating thereby to permit regeneration of said articular cartilage in a skeletal joint.

Claim 9

Independent Claim 87 words

A device for implantation in a mammal which serves as a template for forming in vivo articular cartilage replacement tissue which is long term mechanically and functionally viable, in a skeletal, joint the device comprising: exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including articular cartilage, said tissues defining a unitary structure which allows the attachment of infiltrating thereby to permit regeneration of said articular cartilage in a skeletal joint.

Claim 10

Independent Claim 99 words

A device for implantation in a mammal which serves as a template for forming in vivo replacement of non-mineralized tissue which is long term mechanically and functionally viable in a skeletal joint, the device comprising: exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue corresponding in kind to said tissue to be replaced said matrix defining a unitary structure which allows the attachment of infiltrating cells thereby to permit regeneration of non-mineralized tissue in a skeletal joint.

Claim 11

Independent Claim 99 words

A device for implantation in a mammal which serves as a template for forming in vivo replacement of non-mineralized tissue which is long term mechanically and functionally viable in a skeletal joint, the device comprising: exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue corresponding in kind to said tissue to be replaced said matrix defining a unitary structure which allows the attachment of infiltrating cells thereby to permit regeneration of non-mineralized tissue in a skeletal joint.

Claim 12

Dependent Claim 13 words

The device of claim 8 wherein said non-mineralized tissue is an avascular tissue.

Claim 13

Dependent Claim 29 words

The device of claim 8 wherein said non-mineralized tissue is selected from the group consisting of articular cartilage, ligament, tendon, synovial membrane, menisci, intervertebral discs, and joint capsule tissue.

Claim 14

Dependent Claim 16 words

The device of claim 7 or 8 wherein said matrix comprises devitalized allogenic or xenogenic tissue.

Claim 15

Dependent Claim 38 words

The device of claim 1, 7 or 8 further comprising a material selected from the group consisting of: collagen, polymers comprising monomers of lactic acid, glycolic acid, butyric acid and combinations thereof, hydroxyapatite, tricalcium phosphate, and mixtures thereof.

Claim 16

Dependent Claim 19 words

The device of claim 12 further comprising a material suitable for binding particulate matter to form a moldable solid.

Claim 17

Dependent Claim 32 words

The device of claim 1, 7, or 8, wherein said exogenous osteogenic protein comprises homodimers or heterodimers of OP-1, OP-2, BMP2, BMP3, BMP4, BMP5, BMP6, OPX, or phylogenetic and biosynthetic variants thereof.

Claim 18

Dependent Claim 21 words

The device of claim 1, 7 or 8 wherein said skeletal joint defines a portion of a synovial or articulating joint.

Claim 19

Dependent Claim 13 words

The device of claim 1, 7 or 8 wherein said matrix is devitalized.

Claim 20

Dependent Claim 20 words

The device of claim 1, 7 or 8 wherein said exogenous osteogenic protein is OP-1 or a related osteogenic protein.

Claim 21

Dependent Claim 15 words

The device of claim 1, 7 or 8 wherein said exogenous osteogenic protein is OP-1.

Claim 22

Independent Claim 152 words

A method for inducing in a mammal the formation of a replacement skeletal joint which is long term mechanically and functionally viable, said method comprising the steps of: a) providing a device which serves as a template comprising exogenous osteogenic protein disposed on the surface of a bioresorbable, biocompatible matrix, said matrix defining a single unitary intact structure allowing the attachment of infiltrating cells, and, comprising plural distinct tissues from a proximal or distal hemi-joint including at least one non-mineralized tissue of a joint and including bone underlying the articular surface wherein said underlying bone extends through the margin of articular cartilage into the supporting cancellous bone of said proximal or distal hemi-joint, and, having dimensions and shape which conform to the skeletal joint to be replaced; and b) implanting said device at a locus in a mammal, thereby to induce formation of a functional replacement skeletal joint comprising plural distinct tissues.

Claim 23

Independent Claim 152 words

A method for inducing in a mammal the formation of a replacement skeletal joint which is long term mechanically and functionally viable, said method comprising the steps of: a) providing a device which serves as a template comprising exogenous osteogenic protein disposed on the surface of a bioresorbable, biocompatible matrix, said matrix defining a single unitary intact structure allowing the attachment of infiltrating cells, and, comprising plural distinct tissues from a proximal or distal hemi-joint including at least one non-mineralized tissue of a joint and including bone underlying the articular surface wherein said underlying bone extends through the margin of articular cartilage into the supporting cancellous bone of said proximal or distal hemi-joint, and, having dimensions and shape which conform to the skeletal joint to be replaced; and b) implanting said device at a locus in a mammal, thereby to induce formation of a functional replacement skeletal joint comprising plural distinct tissues.

Claim 24

Dependent Claim 31 words

The method of claim 19 wherein at least one non-mineralized tissue is selected from the group consisting of articular cartilage, ligament, tendon, joint capsule, menisci, intervertebral discs, and synovial membrane tissue.

Claim 25

Dependent Claim 14 words

The method of claim 19 wherein said matrix comprises devitalized allogenic or xenogenic tissue.

Claim 26

Dependent Claim 16 words

The method of claim 19 wherein one of said plural distinct tissues is an avascular tissue.

Claim 27

Independent Claim 94 words

A method for repairing in vivo in a mammal an articular cartilage defect the method comprising the step of: providing to said defect in a mammal a device which serves as a template comprising an exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint articular cartilage, said tissues defining a structure which allows the attachment of infiltrating cells thereby to permit regeneration of said articular cartilage in a skeletal joint which is long term mechanically and functionally viable.

Claim 28

Independent Claim 94 words

A method for repairing in vivo in a mammal an articular cartilage defect the method comprising the step of: providing to said defect in a mammal a device which serves as a template comprising an exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint articular cartilage, said tissues defining a structure which allows the attachment of infiltrating cells thereby to permit regeneration of said articular cartilage in a skeletal joint which is long term mechanically and functionally viable.

Claim 29

Dependent Claim 29 words

The method of claim 18 or 23 wherein said osteogenic protein comprises homodimers or heterodimers of OP-1, BMP2, BMP3, BMP4, BMP5, BMP6, OPX or phylogenetic and biosynthetic variants thereof.

Claim 30

Dependent Claim 18 words

The method of claim 19 or 23 wherein said exogenous osteogenic protein is OP-1 or a related protein.

Claim 31

Dependent Claim 14 words

The method of claim 19 or 23 wherein said exogenous osteogenic protein is OP-1.

Claim 32

Dependent Claim 13 words

The method of claim 23 wherein said defect occurs in a synovial cavity.

Claim 33

Dependent Claim 16 words

The method of claim 23 wherein said matrix is derived from allogenic or xenogenic articular cartilage.

Claim 34

Dependent Claim 25 words

The method of claim 23 wherein said device further comprises collagen, polymers comprising lactic acid, butyric glycolic acid or mixtures thereof; hydroxyapatite and combinations thereof.

Claim 35

Independent Claim 108 words

A method for repairing in vivo in a mammal a non-mineralized tissue defect in a skeletal joint, the method comprising the step of: providing to said defect a device which serves as a template comprising exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue corresponding in kind to said tissue to be replaced, said matrix defining a unitary structure which allows the attachment of infiltrating cells thereby to permit regeneration of said non-mineralized tissue in a skeletal joint which is long term mechanically and functionally viable.

Claim 36

Independent Claim 108 words

A method for repairing in vivo in a mammal a non-mineralized tissue defect in a skeletal joint, the method comprising the step of: providing to said defect a device which serves as a template comprising exogenous osteogenic protein disposed on the surface of a biocompatible, bioresorbable matrix, said matrix comprising plural distinct tissues derived from a proximal or distal hemi-joint including at least one non-mineralized tissue corresponding in kind to said tissue to be replaced, said matrix defining a unitary structure which allows the attachment of infiltrating cells thereby to permit regeneration of said non-mineralized tissue in a skeletal joint which is long term mechanically and functionally viable.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2003-08-29	2004-02-28	2004-08-29	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2007-08-29	2008-02-28	2008-08-29	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2011-08-29	2012-02-28	2012-08-29	$7700.00	Window Closed / Lapsed

Manufacture of autogenous replacement body parts

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