Patent US2965843A successfully refreshed from Google Patents.
Patent US6099567A successfully refreshed from Google Patents.
US6099567A
Expired / Lapsed
US
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Stomach submucosa derived tissue graft
Assignee: Purdue Research Foundation
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Filing: 1997-12-10
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Granted: 2000-08-08
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Expires: 2017-12-10
Abstract
Abstract A tissue graft composition comprising stomach submucosal tissue delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate is described. The graft composition can be or implanted into a host to replace or support damaged or diseased tissues.
Inventors
- 👤 Stephen F. Badylak
- 👤 Sherry L. Voytik-Harbin
- 👤 Andrew O. Brightman
- 👤 Robert S. Tullius
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:16
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3604; A61L27/3641; A61L27/3645; A61P; A61P43/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
51 words
A composition capable of inducing the formation of endogenous tissue when implanted at a site in need of endogenous tissue growth comprising stomach submucosa delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
Claim 2
Dependent Claim
51 words
A composition capable of inducing the formation of endogenous tissue when implanted at a site in need of endogenous tissue growth comprising stomach submucosa delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
Claim 3
Dependent Claim
11 words
The composition of claim 1 wherein the stomach submocosa is fluidized.
Claim 4
Dependent Claim
31 words
The composition of claim 1 wherein the stomach submucosa is digested with an enzyme for a period of time sufficient to solubilize the stomach submucosa and provide a substantially homogenous solution.
Claim 5
Dependent Claim
14 words
The composition of claim 2, wherein the stomach submucosais dried and in powder form.
Claim 6
Dependent Claim
22 words
The composition of claim 1 formed into a cylinder having a predetermined luminal diameter and sutured along the length of the cylinder.
Claim 7
Dependent Claim
22 words
The composition of claim 1 conditioned to reduce the strain of the isolated stomach submucosa for use as a connective tissue substitute.
Claim 8
Dependent Claim
33 words
The composition of claim 6 wherein the stomach submucosa is conditioned by stretching to produce a graft construct longer in at least one dimension than the stomach submucosa from which it is formed.
Claim 9
Dependent Claim
55 words
The use of stomach submucosa for the preparation of a tissue graft construct useful for inducing endogenous tissue growth when implanted in warm-blooded vertebrates, said stomach submucosa being delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
Claim 10
Dependent Claim
55 words
The use of stomach submucosa for the preparation of a tissue graft construct useful for inducing endogenous tissue growth when implanted in warm-blooded vertebrates, said stomach submucosa being delaminated from both the luminal portion of the tunica mucosa and the smooth muscle layers of the muscularis externa of a stomach of a warm blooded vertebrate.
Claim 11
Dependent Claim
14 words
The use according to claim 8 wherein the stomach submucosa is in fluidized form.
Claim 12
Dependent Claim
14 words
The use according to claim 8 wherein the stomach submucosa is in powder form.
Claim 13
Independent Claim
52 words
A method for inducing the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm blooded vertebrate, said method comprising contacting said site with a graft composition comprising stomach submucosa in an amount effective to induce endogenous tissue growth at the site the composition is administered.
Claim 14
Independent Claim
52 words
A method for inducing the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm blooded vertebrate, said method comprising contacting said site with a graft composition comprising stomach submucosa in an amount effective to induce endogenous tissue growth at the site the composition is administered.
Claim 15
Dependent Claim
20 words
The method of claim 11, wherein the graft composition is fluidized and is administered by injection into the warm-blooded vertebrate.
Claim 16
Dependent Claim
20 words
The method of claim 12, wherein the graft composition is administered by surgically implanting the composition into the warm-blooded vertebrate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-08 | 2004-02-07 | 2004-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-08 | 2008-02-07 | 2008-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-08 | 2012-02-07 | 2012-08-08 | $7700.00 | Window Closed / Lapsed |