Patent DE213257C successfully refreshed from Google Patents.
US6099562A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug coating with topcoat
Assignee: Boston Scientific Scimed Inc
•
Filing: 1997-12-22
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Granted: 2000-08-08
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Expires: 2017-12-22
Abstract
Abstract A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.
Inventors
- 👤 Ni Ding
- 👤 Michael N. Helmus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:42
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/141; A61L31/16; A61F2210/00; A61F2210/0014; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/416; A61L2300/42; A61L2300/60; A61L2300/602; A61L2300/606; A61L2300/608; A61L2420/00; A61L2420/08
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
116 words
A medical device having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens.
Claim 2
Dependent Claim
116 words
A medical device having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens.
Claim 3
Dependent Claim
19 words
The device of claim 1 wherein the topcoat covers less than the entire undercoat while the device is implanted.
Claim 4
Dependent Claim
19 words
The device of claim 1 wherein the topcoat covers less than the entire undercoat before the device is implanted.
Claim 5
Dependent Claim
25 words
The device of claim 1 wherein the topcoat covers less than the entire undercoat before the device is implanted and while the device is implanted.
Claim 6
Dependent Claim
48 words
The device of claim 1 wherein the polymeric material of the undercoat is a hydrophobic elastomeric material and wherein the polymeric material of the topcoat is a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.
Claim 7
Dependent Claim
26 words
The device of claim 1 wherein the topcoat reduces a burst release of the biologically active material as compared to a coated device without the topcoat.
Claim 8
Dependent Claim
12 words
The device of claim 1 wherein the biologically active material is heparin.
Claim 9
Dependent Claim
28 words
The device of claim 1 wherein the polymeric material of the topcoat is selected from the group consisting of fluorosilicone, polyethylene glycol (PEG), polysaccharides, phospholipids and combinations thereof.
Claim 10
Dependent Claim
11 words
The device of claim 8 wherein the polymeric material is fluorosilicone.
Claim 11
Dependent Claim
13 words
The device of claim 8 wherein the polymeric material is polyethylene glycol (PEG).
Claim 12
Dependent Claim
20 words
The device of claim 1 wherein the topcoat covers from about 5% to 95% of the surface of the undercoat.
Claim 13
Dependent Claim
20 words
The device of claim 11 wherein the topcoat covers from about 20% to 85% of the surface of the undercoat.
Claim 14
Dependent Claim
18 words
The device of claim 1 wherein the topcoat has an average thickness of about 1 to 7 microns.
Claim 15
Dependent Claim
18 words
The device of claim 13 wherein the topcoat has an average thickness of about 1 to 5 microns.
Claim 16
Dependent Claim
23 words
The device of claim 1 wherein the topcoat has an average thickness of about the average particle size of the biologically active material.
Claim 17
Dependent Claim
12 words
The device of claim 1 wherein the device is an expandable stent.
Claim 18
Dependent Claim
19 words
The device of claim 1 wherein the polymeric materials of the topcoat and the bottom coat are water permeable.
Claim 19
Independent Claim
161 words
A method of using an implantable stent prosthesis comprising: (a) providing an implantable stent prosthesis having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens; (b) implanting the device into the body of a patient; and (c) allowing the biologically active material to be released such that the topcoat limits the burst release of the biologically active material.
Claim 20
Independent Claim
161 words
A method of using an implantable stent prosthesis comprising: (a) providing an implantable stent prosthesis having at least a portion which is implantable into the body of a patient, wherein at least a part of the device portion is covered with a coating for release of at least one biologically active material, wherein said coating comprises an undercoat having an outer surface and comprising a polymeric material incorporating an amount of biologically active material therein for timed release therefrom, and wherein said coating further comprises a topcoat formed of a discontinuous coating being disposed over the entire outer surface of the undercoat, thereby forming covered and uncovered areas of the undercoat throughout the entire outer surface, said topcoat comprising a polymeric material substantially free of pores and porosigens; (b) implanting the device into the body of a patient; and (c) allowing the biologically active material to be released such that the topcoat limits the burst release of the biologically active material.
Claim 21
Dependent Claim
19 words
The method of claim 18 wherein the topcoat remains on the undercoat after release of the biologically active material.
Claim 22
Dependent Claim
19 words
The method of claim 18 wherein the topcoat covers less than the entire undercoat while the device is implanted.
Claim 23
Dependent Claim
19 words
The method of claim 18 wherein the topcoat covers less than the entire undercoat before the device is implanted.
Claim 24
Dependent Claim
25 words
The method of claim 18 wherein the topcoat covers less than the entire undercoat before the device is implanted and while the device is implanted.
Claim 25
Dependent Claim
48 words
The method of claim 18 wherein the polymeric material of the undercoat is a hydrophobic elastomeric material and wherein the polymeric material of the topcoat is a biostable, biocompatible material which provides long term non-thrombogenicity to the stent portion during and after release of the biologically active material.
Claim 26
Dependent Claim
28 words
The method of claim 18 wherein the polymeric material of the topcoat is selected from the group consisting of fluorosilicone, polyethylene glycol (PEG), polysaccharides, phospholipids and combinations thereof.
Claim 27
Dependent Claim
20 words
The method of claim 18 wherein the topcoat covers from about 5% to 95% of the surface of the undercoat.
Claim 28
Dependent Claim
23 words
The method of claim 18 wherein the topcoat has an average thickness of about the average particle size of the biologically active material.
Claim 29
Dependent Claim
18 words
The method of claim 18 wherein the topcoat has an average thickness of about 1 to 7 microns.
References Cited (Backward Citations)
US3932627A
Cited
US4219520A
Cited
US4292965A
Cited
US4613665A
Cited
US4954126B1
Cited
US4954126A
Cited
US4655771B1
Cited
US4655771A
Cited
US4872867A
Cited
US5061275A
Cited
US4886062A
Cited
US4916193A
Cited
US5185408A
Cited
US5318779A
Cited
US5262451A
Cited
US5338770A
Cited
US5182317A
Cited
US5092877A
Cited
US5226913A
Cited
US5292802A
Cited
US5308889A
Cited
US4994071A
Cited
US5415619A
Cited
US5496557A
Cited
WO1991012779A1
Cited
US5545208A
Cited
US5447724A
Cited
US5163952A
Cited
US5258020A
Cited
US5180366A
Cited
US5304121A
Cited
WO1992015286A1
Cited
US5356433A
Cited
US5429618A
Cited
US5449382A
Cited
US5342348A
Cited
US5419760A
Cited
US5391378A
Cited
WO1994021308A1
Cited
WO1994021309A1
Cited
US5464650A
Cited
EP0623354A1
Cited
US5624411A
Cited
US5716981A
Cited
US5380299A
Cited
US5543155A
Cited
US5629077A
Cited
WO1996000272A1
Cited
US5637113A
Cited
EP0734721A2
Cited
US5824054A
Cited
US5779732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-08 | 2004-02-07 | 2004-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-08 | 2008-02-07 | 2008-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-08 | 2012-02-07 | 2012-08-08 | $7700.00 | Window Closed / Lapsed |