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US5924973A
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Method of treating a disease process in a luminal structure
Assignee: Columbia University
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Filing: 1996-09-26
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Granted: 1999-07-20
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Expires: 2016-09-26
Abstract
Abstract An apparatus and a method of inhibiting a disease process in a luminal structure of a subject including introducing within the luminal structure a complex of a radionuclide and a chelating agent in an amount effective to inhibit the disease process.
Inventors
- 👤 Judah Z. Weinberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:53
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1282; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1002; A61B; A61B17/00; A61B17/22; A61B2017/22051; A61B2017/22062
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
58 words
A method of inhibiting a disease process in a luminal structure of a subject comprising introducing within the luminal structure a complex of a radionuclide and a chelating agent, said complex being introduced in an amount effective to inhibit the disease process and said chelating agent of said complex controlling the biodistribution of the complex in the subject.
Claim 2
Independent Claim
58 words
A method of inhibiting a disease process in a luminal structure of a subject comprising introducing within the luminal structure a complex of a radionuclide and a chelating agent, said complex being introduced in an amount effective to inhibit the disease process and said chelating agent of said complex controlling the biodistribution of the complex in the subject.
Claim 3
Dependent Claim
11 words
The method of claim 1, wherein the subject is a mammal.
Claim 4
Dependent Claim
11 words
The method of claim 2, wherein the subject is a human.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein the radionuclide is 188 Re.
Claim 6
Dependent Claim
13 words
The method of claim 1, wherein the chelating agent is MAG 3 .
Claim 7
Dependent Claim
14 words
The method of claim 1, wherein the complex is a 188 Re-MAG 3 complex.
Claim 8
Dependent Claim
21 words
The method of claim 1, wherein the complex is introduced within the luminal structure through a catheter in the luminal structure.
Claim 9
Dependent Claim
12 words
The method of claim 7, wherein the catheter is a balloon catheter.
Claim 10
Dependent Claim
11 words
The method of claim 1, wherein the disease process is restenosis.
Claim 11
Dependent Claim
12 words
The method of claim 1, wherein the disease process is cell proliferation.
Claim 12
Dependent Claim
23 words
The method of claim 10, wherein the cell proliferation is associated with an endobronchial, bile duct, gastrointestinal, cervical, urinary bladder, or endometrial tumor.
Claim 13
Dependent Claim
12 words
The method of claim 1, wherein the luminal structure is an artery.
Claim 14
Dependent Claim
41 words
The method of claim 1, wherein the luminal structure is a vein, a bypass graft prosthesis, a portion of the gastrointestinal tract, a portion of the biliary tract, a portion of the genitourinary tract, or a portion of the respiratory tract.
Claim 15
Dependent Claim
36 words
The method of claim 1, wherein said radionuclide is Na-24, Si-31, K-42, Sc-44, Co-55, Cu-61, Ga-66, Ga-68, Ga-72, Se-73, Sr-75, Br-76, Kr-77, Ge-77, Sr-90, Y-90, Tc-99, Tc-99m, Pd-103, In-110, Sb-122, I-125, Ho-166, Re-186, Ir-192, or Bi-212.
Claim 16
Independent Claim
120 words
An apparatus for treating a disease process in a luminal structure of a subject comprising: a balloon catheter with a fluid delivery port connected thereto for insertion and removal of fluid, said balloon catheter having a size sufficiently small to be received in a luminal structure of a subject; and a radioactive fluid in the balloon catheter, said radioactive fluid comprising a complex of a radionuclide and a chelating agent, said complex being present in an amount effective to inhibit the disease process and said chelating agent of said complex being present in an amount effective for controlling the biodistribution of the complex in the subject in the event that at least some of the complex escapes the balloon catheter.
Claim 17
Independent Claim
120 words
An apparatus for treating a disease process in a luminal structure of a subject comprising: a balloon catheter with a fluid delivery port connected thereto for insertion and removal of fluid, said balloon catheter having a size sufficiently small to be received in a luminal structure of a subject; and a radioactive fluid in the balloon catheter, said radioactive fluid comprising a complex of a radionuclide and a chelating agent, said complex being present in an amount effective to inhibit the disease process and said chelating agent of said complex being present in an amount effective for controlling the biodistribution of the complex in the subject in the event that at least some of the complex escapes the balloon catheter.
Claim 18
Dependent Claim
11 words
The apparatus of claim 15, wherein the radionuclide is 188 Re.
Claim 19
Dependent Claim
36 words
The apparatus of claim 15, wherein said radionuclide is Na-24, Si-31, K-42, Sc-44, Co-55, Cu-61, Ga-66, Ga-68, Ga-72, Se-73, Sr-75, Br-76, Kr-77, Ge-77, Sr-90, Y-90, Tc-99, Tc-99m, Pd-103, In-110, Sb-122, I-125, Ho-166, Re-186, Ir-192, or Bi-212.
Claim 20
Dependent Claim
13 words
The apparatus of claim 15, wherein the chelating agent is MAG 3 .
Claim 21
Dependent Claim
14 words
The apparatus of claim 15, wherein the complex is a 188 Re-Mag 3 complex.
Claim 22
Dependent Claim
25 words
A method of treating a disease process in a luminal structure of a subject comprising introducing within the luminal structure the apparatus of claim 15.
Claim 23
Dependent Claim
11 words
The method of claim 20, wherein the disease process is restenosis.
Claim 24
Dependent Claim
12 words
The method of claim 20, wherein the disease process is cell proliferation.
Claim 25
Dependent Claim
21 words
The method of claim 22, wherein the cell proliferation is associated with an endobronchial, bile duct, gastrointestinal, cervical, or endometrial tumor.
Claim 26
Dependent Claim
12 words
The method of claim 20, wherein the luminal structure is an artery.
Claim 27
Dependent Claim
41 words
The method of claim 20, wherein the luminal structure is a vein, a bypass graft prosthesis, a portion of the gastrointestinal tract, a portion of the biliary tract, a portion of the genitourinary tract, or a portion of the respiratory tract.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2002-07-19 | 2003-01-18 | 2003-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-19 | 2007-01-18 | 2007-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-19 | 2011-01-18 | 2011-07-20 | $7700.00 | Window Closed / Lapsed |