US5245018A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing a radiopharmaceutical composition
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1991-10-29
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Granted: 1993-09-14
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Expires: 2011-10-29
Abstract
Abstract A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH 2 CO--NHCH 2 CO--NHCH 2 CO--NHCH 2 COOH (mercaptoacetylglycylglycylglycine, MAG3), (b) a watersoluble reducing agent, (c) a water-soluble stabilizing agent in an amount of not less than 70 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11; and (2) heating the resultant mixture at a temperature of about 90 to 140° C. Said process removes any troublesome labeling operation at the diagnostic site and relieve the practitioners from the exposure to radiation during the labeling operation.
Inventors
- 👤 Susumu Kondo
- 👤 Sakae Okano
- 👤 Makoto Azuma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:49
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K2123/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
103 words
A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH 2 CO--NHCH 2 CO--NHCH 2 CO--NHCH 2 COOH (mercaptoacetylgycylglycylglycine, MAG3), (b) a water-soluble reducing agent, (c) a water-soluble stabilizing agent for the reduced technetium present in the reaction medium, in an amount of from about 70 mol to 100 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11 in the absence of any exchange ligand; and (2) heating the resultant mixture at a temperature of about 90 to 140° C.
Claim 2
Dependent Claim
103 words
A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of: (1) mixing (a) HSCH 2 CO--NHCH 2 CO--NHCH 2 CO--NHCH 2 COOH (mercaptoacetylgycylglycylglycine, MAG3), (b) a water-soluble reducing agent, (c) a water-soluble stabilizing agent for the reduced technetium present in the reaction medium, in an amount of from about 70 mol to 100 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11 in the absence of any exchange ligand; and (2) heating the resultant mixture at a temperature of about 90 to 140° C.
Claim 3
Dependent Claim
15 words
The process according to claim 1, wherein the water-soluble reducing agent is a stannous salt.
Claim 4
Dependent Claim
32 words
The process according to claim 1, wherein the water-soluble stabilizing agent is any one selected from the group consisting of ascorbic acid and erythorbic acid, and their pharmaceutically acceptable salts and esters.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-13 | 1997-03-15 | 1997-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-13 | 2001-03-15 | 2001-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-13 | 2005-03-15 | 2005-09-14 | $7700.00 | Window Closed / Lapsed |