US5906997A
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Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
Assignee: FzioMed Inc
•
Filing: 1997-06-17
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Granted: 1999-05-25
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Expires: 2017-06-17
Abstract
Abstract The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides and polyethers, and to the resulting compositions. The polymers are associated with each other, and are then either dried or are used as fluids. Bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent the formation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. Membranes are inserted during surgery either dry or optionally after conditioning in aqueous solutions. The anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and physical properties of such membranes can be varied as needed by carefully adjusting the pH of the polymer casting solutions, polysaccharide composition, the polyether composition, or by conditioning the membranes prior to surgical use. Bi- or multi-layered membranes can be made and used to provide further control over the physical and biological properties of antiadhesion membranes. Antiadhesion compositions may also be used to deliver drugs to the surgical site and release them locally.
Inventors
- 👤 Herbert E. Schwartz
- 👤 John M. Blackmore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:01
CPC Classifications
B; B01; B01D; B01D69/00; C; C08; C08L; C08L1/00; C08L1/08; C08L1/26; C08L1/28; C08L1/286; A; A61; A61L; A61L31/00; A61L31/04; A61L31/041; A61L31/042; A61L31/14; A61L31/145; C08B; C08B11/00; C08B11/20; C08B15/00; C08B37/00; C08L5/00; C08L71/00; C08L71/02
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 3.0 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 2
Dependent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 3.0 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 3
Dependent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 3.5 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 4
Dependent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 3.5 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 5
Dependent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 4.1 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 6
Dependent Claim
61 words
A membrane comprising an association complex of a carboxypolysaccharide (CPS) and a polyether (PE), which possesses at least one property selected from the group consisting of bioresorbable, bioadhesive, antithrombogenic, and antiadhesion, wherein the pH of the solution from which the membrane is made is between about 4.1 and about 7.0, and wherein the membrane is hydratable by at least about 100%.
Claim 7
Dependent Claim
35 words
The membrane as in claim 1, wherein the CPS is selected from the group consisting of carboxymethyl cellulose (CMC), carboxyethyl cellulose, hyaluronic acid, alginate, carboxymethyl chitosan, pectin, carboxymethyl dextran, heparin, heparin sulfate, and chondroitin sulfate.
Claim 8
Dependent Claim
20 words
The membrane as in claim 1, wherein the molecular weight of the CPS is between 100 kd and 10,000 kd.
Claim 9
Dependent Claim
25 words
The membrane as in claim 1, wherein the CPS is CMC, and the molecular weight of the CMC is between 600 kd and 5000 kd.
Claim 10
Dependent Claim
17 words
The membrane as in claim 6, wherein the molecular weight of the CMC is approximately 700 kd.
Claim 11
Dependent Claim
27 words
The membrane as in claim 1, wherein the PE is polyethylene oxide (PEO), and the molecular weight of the PEO is between 5 kd and 8000 kd.
Claim 12
Dependent Claim
20 words
The membrane as in claim 8, wherein the molecular weight of the PEO is between 100 kd and 5000 kd.
Claim 13
Dependent Claim
17 words
The membrane as in claim 8, wherein the molecular weight of the PEO is approximately 5000 kd.
Claim 14
Dependent Claim
32 words
The membrane as in claim 1, wherein the proportion of the CPS is from 10% to 95% by weight, and the amount of the PE is from 5% to 90% by weight.
Claim 15
Dependent Claim
28 words
The membrane as in claim 1, wherein the degree of substitution of the CPS includes the range from greater than about 0 up to and including about 3.
Claim 16
Dependent Claim
21 words
The membrane as in claim 1, wherein the degree of substitution of the CPS is between about 0.3 and about 2.
Claim 17
Dependent Claim
21 words
The membrane as in claim 1, wherein the degree of substitution of the CPS is between about 0.5 and about 1.7.
Claim 18
Dependent Claim
21 words
The membrane as in claim 1, wherein the degree of substitution of the CPS is between about 0.65 and about 1.5.
Claim 19
Dependent Claim
10 words
The membrane as in claim 1, further comprising a drug.
Claim 20
Dependent Claim
25 words
The membrane as in claim 16, wherein said drug is selected from the group consisting of antibiotics, anti-inflammatory drugs, hormones, chemotactic factors, analgesics, and anesthetics.
Claim 21
Dependent Claim
179 words
A membrane made according to the following steps: selecting a CPS with a molecular weight in the range of about 100 kd and about 10,000 kd and having a degree of substitution in the range of about greater than about 0 and up to and including about 3, dissolving said CPS in an aqueous medium to form a solution of CPS, selecting a PE with molecular weight in the range of about 5 kd and about 8000 kd, dissolving said PE in an aqueous medium to form a solution of PE, mixing said solution of CPS and said solution of PE together to form a casting solution, wherein the casting solution has a proportion of CPS is from about 10% to about 95% by weight, and the casting solution has a proportion of PE is in the range of about 5% to about 90% by weight, adjusting the pH of the casting solution to between about 3.0 and about 7.0; and drying said casting solution to form a membrane, wherein said membrane is hydratable by at least about 100%.
Claim 22
Dependent Claim
179 words
A membrane made according to the following steps: selecting a CPS with a molecular weight in the range of about 100 kd and about 10,000 kd and having a degree of substitution in the range of about greater than about 0 and up to and including about 3, dissolving said CPS in an aqueous medium to form a solution of CPS, selecting a PE with molecular weight in the range of about 5 kd and about 8000 kd, dissolving said PE in an aqueous medium to form a solution of PE, mixing said solution of CPS and said solution of PE together to form a casting solution, wherein the casting solution has a proportion of CPS is from about 10% to about 95% by weight, and the casting solution has a proportion of PE is in the range of about 5% to about 90% by weight, adjusting the pH of the casting solution to between about 3.0 and about 7.0; and drying said casting solution to form a membrane, wherein said membrane is hydratable by at least about 100%.
Claim 23
Dependent Claim
35 words
The membrane as in claim 18, wherein the CPS is selected from the group consisting of carboxymethyl cellulose (CMC), carboxyethyl cellulose, hyaluronic acid, alginate, carboxymethyl chitosan, pectin, carboxymethyl dextran, heparin, heparin sulfate, and chondroitin sulfate.
Claim 24
Dependent Claim
10 words
The membrane of claim 18 wherein the CPS is carboxymethylcellulose.
Claim 25
Dependent Claim
11 words
The membrane of claim 18 wherein the PE is polyethylene oxide.
Claim 26
Dependent Claim
210 words
A conditioned membrane made according to the following steps: selecting a CPS with a molecular weight in the range of about 100 kd and about 10,000 kd and having a degree of substitution in the range of greater than about 0 and up to and including about 3, dissolving said CPS in an aqueous medium to form a solution of CPS, selecting a PE with molecular weight in the range of about 5 kd and about 8000 kd, dissolving said PE in an aqueous medium to form a solution of PE, mixing said solution of CPS and said solution of PE together to form a casting solution, wherein the casting solution has a proportion of CPS is from about 10% to about 95% by weight, and the casting solution has a proportion of PE is in the range of about 5% to about 90% by weight, adjusting the pH of said casting solution in the range of about 3.0 to about 3.5, permitting the solution of CPS and PE to at least partially dry to form a membrane, conditioning said membrane by immersing said membrane in a solution having a pH above about 3.5, and drying the conditioned membrane, wherein the conditioned membrane is hydratable by at least about 100%.
Claim 27
Dependent Claim
210 words
A conditioned membrane made according to the following steps: selecting a CPS with a molecular weight in the range of about 100 kd and about 10,000 kd and having a degree of substitution in the range of greater than about 0 and up to and including about 3, dissolving said CPS in an aqueous medium to form a solution of CPS, selecting a PE with molecular weight in the range of about 5 kd and about 8000 kd, dissolving said PE in an aqueous medium to form a solution of PE, mixing said solution of CPS and said solution of PE together to form a casting solution, wherein the casting solution has a proportion of CPS is from about 10% to about 95% by weight, and the casting solution has a proportion of PE is in the range of about 5% to about 90% by weight, adjusting the pH of said casting solution in the range of about 3.0 to about 3.5, permitting the solution of CPS and PE to at least partially dry to form a membrane, conditioning said membrane by immersing said membrane in a solution having a pH above about 3.5, and drying the conditioned membrane, wherein the conditioned membrane is hydratable by at least about 100%.
Claim 28
Dependent Claim
35 words
The conditioned membrane of claim 22, wherein the CPS is selected from the group consisting of carboxymethyl cellulose (CMC), carboxyethyl cellulose, hyaluronic acid, alginate, carboxymethyl chitosan, pectin, carboxmethyl dextran, heparin, heparin sulfate, and chondroitin sulfate.
Claim 29
Dependent Claim
17 words
The conditioned membrane of claim 22 wherein the CPS is carboxyymethylcellulose and the PE is polyethylene oxide.
Claim 30
Dependent Claim
30 words
The conditioned membrane of claim 22 wherein said step of conditioning is carried out in a solution selected from the group consisting of phosphate buffered saline, phosphate buffer and ammonia.
Claim 31
Dependent Claim
30 words
The conditioned membrane of claim 23, wherein said step of conditioning is carried out in a solution selected from the group consisting of phosphate buffered saline, phosphate buffer and ammonia.
Claim 32
Dependent Claim
151 words
The membrane as in claim 4 which is at least one of antiadhesion, bioresorbable, anti-thrombogenic, and bioadhesive, and possesses one or more of the following properties; the molecular weight of the CPS in the range of about 100 kd and about 10,000 kd, the molecular weight of PE in the range of about 5 kd and about 8000 kd, the degree of substitution of the CPS in the range of greater than about 0 and up to and including about 3, the proportion of the CPS and the PE, wherein the proportion of the CPS is from about 10% to about 95% by weight, and the proportion of the PE is in the range of about 5% to about 90% by weight, the pH of the casting solutions from which said membrane is made in the range of about 3.0 to about 7.0, and is hydratable by at least about 100%.
Claim 33
Dependent Claim
35 words
The membrane as in claim 4, wherein the CPS is selected from the group consisting of carboxymethyl cellulose (CMC), carboxyethyl cellulose, hyaluronic acid, alginate, carboxymethyl chitosan, pectin, carboxymethyl dextran, heparin, heparin sulfate, and chondroitin sulfate.
Claim 34
Dependent Claim
17 words
The membrane of claim 4 wherein the CPS is carboxymethylcellulose and wherein the PE is polyethylene oxide.
Claim 35
Dependent Claim
32 words
The membrane as in claim 4, wherein the proportion of the CPS is from 10% to 95% by weight, and the amount of the PE is from 5% to 90% by weight.
Claim 36
Dependent Claim
25 words
The membrane as in claim 2, wherein the CPS is CMC, and the molecular weight of the CMC is between 600 kd and 5000 kd.
Claim 37
Dependent Claim
27 words
The membrane as in claim 2, wherein the PE is polyethylene oxide (PEO), and the molecular weight of the PEO is between 5 kd and 8000 kd.
Claim 38
Dependent Claim
25 words
The membrane as in claim 3, wherein the CPS is CMC, and the molecular weight of the CMC is between 600 kd and 5000 kd.
Claim 39
Dependent Claim
27 words
The membrane as in claim 3, wherein the PE is polyethylene oxide (PEO), and the molecular weight of the PEO is between 5 kd and 8000 kd.
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