US5356883A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
Assignee: Anika Therapeutics Inc
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Filing: 1992-07-28
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Granted: 1994-10-18
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Expires: 2012-07-28
Abstract
Abstract This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a nucleophile or a polyanionic polysaccharide. The water-insoluble gels, films and sponges of this invention may be used as surgical aids to prevent adhesions of body tissues and as drug delivery vehicles.
Inventors
- 👤 Jing-wen Kuo
- 👤 David A. Swann
- 👤 Glenn D. Prestwich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:40
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/30; A61K47/36; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K47/69; A61K47/6903; A61K9/0019; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L27/00; A61L27/14; A61L27/20; A61L31/00; A61L31/04; A61L31/042; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
88 words
A method of separating healing tissues nd maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 2
Independent Claim
88 words
A method of separating healing tissues nd maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 3
Independent Claim
87 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of or more carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Claim 4
Independent Claim
87 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a water insoluble biocompatible gel comprising a modified hyaluronic acid in which at least about 5% of or more carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said gel preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Claim 5
Independent Claim
86 words
A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 6
Independent Claim
86 words
A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 7
Independent Claim
82 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Claim 8
Independent Claim
82 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible film comprising modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said film preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Claim 9
Independent Claim
86 words
A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 10
Independent Claim
86 words
A method of separating healing tissues and maintaining said separation during the healing process after surgery, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge causing said separation of the healing tissues to be established and maintained post-operatively for a period of at least about seven days.
Claim 11
Independent Claim
83 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
Claim 12
Independent Claim
83 words
A method of preventing post-operative adhesion between healing tissues during the healing process, said method comprising introducing into a surgical site, either during surgery or post-operatively, a biocompatible sponge comprising a modified hyaluronic acid in which at least about 5% of carboxyl functionalities have been derivatized, and wherein essentially all of the derivatized functionalities are O-acyl or N-acyl ureas, said sponge preventing said adhesion of the healing tissues to be established and maintained post-operatively for a period of at least about 7 days.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-17 | 1998-04-18 | 1998-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-17 | 2002-04-18 | 2002-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-17 | 2006-04-18 | 2006-10-18 | $7700.00 | Window Closed / Lapsed |