US5266326A
Expired / Lapsed
US
⏱️ 0.0 years remaining
In situ modification of alginate
Assignee: Howmedica Osteonics Corp
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Filing: 1992-06-30
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Granted: 1993-11-30
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Expires: 2012-06-30
Abstract
Abstract A method of modifying salts of alginic acid in situ for prevention and treatment of various intra-articular and extra-articular (spine) complications modifies the alginate in situ to an insoluble gel. This in situ modification provides a final product which can be compressed within the intra-articular space thus remaining localized. The modified material can have varied mechanical strengths and thus varied degradation times and can serve as a matrix for localizing and slowly releasing therapeutic agents. The modified material is biocompatible and biodegradable, thus requiring no reoperation for removal.
Inventors
- 👤 James J. Barry
- 👤 Paul A. Higham
- 👤 Harold M. Aberman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:06
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0084; A; A61; A61L; A61L31/00; A61L31/04; A61L31/042; A61P; A61P43/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
52 words
A method for preventing adhesions in situ between tissues after surgery comprising the steps of: injecting a water soluble 0.1% to 4% alginate solution into the intra-articular space prior to or after closing the surgical site; and injecting a 0.5% to 2% complexing solution of water soluble cations into said intraarticular space.
Claim 2
Independent Claim
52 words
A method for preventing adhesions in situ between tissues after surgery comprising the steps of: injecting a water soluble 0.1% to 4% alginate solution into the intra-articular space prior to or after closing the surgical site; and injecting a 0.5% to 2% complexing solution of water soluble cations into said intraarticular space.
Claim 3
Dependent Claim
35 words
The method for preventing adhesions as set forth in claim 1 wherein said alginate is selected from the group consisting of sodium alginate, alginic acid, calcium alginate, magnesium alginate, potassium alginate and a combination thereof.
Claim 4
Dependent Claim
24 words
The method for preventing adhesions between tissues as set forth in claim 2 wherein said alginate solution and said complexing solution are injected simultaneously.
Claim 5
Dependent Claim
31 words
The method for preventing adhesions as set forth in claim 2 wherein said step of simultaneously injecting said alginate solution and said complexing solution is done with a double lumen needle.
Claim 6
Dependent Claim
25 words
The method for preventing adhesions between tissues as set forth in claim 1 wherein said complexing solution is injected after said alginate solution is injected.
Claim 7
Dependent Claim
34 words
The method for preventing adhesions between tissues as set forth in claim 1 wherein said complexing solution is selected from the group consisting of magnesium chloride, calcium sulfate, calcium chloride and a combination thereof.
Claim 8
Independent Claim
44 words
A method for preventing adhesions in situ between tissues comprising the steps of: placing a water soluble 0.1% to 4% alginate solution between the tissues; and cross-linking the alginate by placing a 0.5% to 2% complexing solution of water soluble cations between the tissues.
Claim 9
Independent Claim
44 words
A method for preventing adhesions in situ between tissues comprising the steps of: placing a water soluble 0.1% to 4% alginate solution between the tissues; and cross-linking the alginate by placing a 0.5% to 2% complexing solution of water soluble cations between the tissues.
Claim 10
Dependent Claim
35 words
The method for preventing adhesions as set forth in claim 7 wherein said alginate is selected from the group consisting of sodium alginate, alginic acid, calcium alginate, magnesium alginate, potassium alginate and a combination thereof.
Claim 11
Dependent Claim
24 words
The method for preventing adhesions between tissues as set forth in claim 7 wherein said alginate solution and said complexing solution are injected simultaneously.
Claim 12
Dependent Claim
31 words
The method for preventing adhesions as set forth in claim 7 wherein said step of simultaneously injecting said alginate solution and said complexing solution is done with a double lumen needle.
Claim 13
Dependent Claim
25 words
The method for preventing adhesions between tissues as set forth in claim 7 wherein said complexing solution is injected after said alginate solution is injected.
Claim 14
Dependent Claim
34 words
The method for preventing adhesions between tissues as set forth in claim 7 wherein said complexing solution is selected from the group consisting of magnesium chloride, calcium sulfate, calcium chloride and a combination thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-29 | 1997-05-31 | 1997-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-29 | 2001-05-31 | 2001-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-29 | 2005-05-31 | 2005-11-30 | $7700.00 | Window Closed / Lapsed |