US5906573A
Expired / Lapsed
US
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Radioactive surgical fastening devices and methods of making same
Assignee: RadioMed Corp
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Filing: 1997-07-18
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Granted: 1999-05-25
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Expires: 2017-07-18
Abstract
Abstract A surgical fastening device, such as a suture, staple, clip, pin or the like, is rendered therapeutically radioactive in order to inhibit cellular proliferation at a wound or surgical repair site, by implantation of a radioisotope into the material of the device. The device can be made of any material, including metals, nonmetals, plastics and ceramics.
Inventors
- 👤 H. Thomas Aretz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:44
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N5/1027; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/82; A61F2210/00; A61F2210/0095; A61N2005/1019
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
54 words
A surgical fastening device capable of controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said fastening device to render said device radioactive.
Claim 2
Dependent Claim
54 words
A surgical fastening device capable of controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said fastening device to render said device radioactive.
Claim 3
Dependent Claim
36 words
A surgical fastening device according to claim 1, wherein said radioactive device is adapted to be selectively positioned at said wound repair site for delivery of a predetermined dose of radiation to said wound repair site.
Claim 4
Dependent Claim
31 words
A surgical fastening device according to claim 1, wherein said surgical fastening device is selected from the group consisting of sutures, staples, clips, pins, nails, screws, plates, barbs, anchors, and patches.
Claim 5
Dependent Claim
17 words
A surgical fastening device according to claim 3, wherein said device is made of a metallic material.
Claim 6
Dependent Claim
18 words
A surgical fastening device according to claim 3, wherein said device is made of a substantially nonmetallic material.
Claim 7
Dependent Claim
17 words
A surgical fastening device according to claim 5, wherein said device is made of a polymeric material.
Claim 8
Dependent Claim
18 words
A surgical fastening device according to claim 5, wherein said device is made of a substantially bioabsorbable material.
Claim 9
Dependent Claim
22 words
A surgical fastening device according to claim 1, wherein said surgical fastening device is adapted for substantially permanent implantation in said patient.
Claim 10
Dependent Claim
23 words
A surgical fastening device according to claim 1, wherein said surgical fastening device is adapted for temporary or removable implantation in said patient.
Claim 11
Dependent Claim
29 words
A surgical fastening device according to claim 1, wherein said radiation source comprises a radioisotope which is adapted to be incorporated into said surgical fastening device by ion implantation.
Claim 12
Dependent Claim
39 words
A surgical fastening device according to claim 10, wherein said radioisotope is selected from the group consisting of 45 Ca, 123 Sn, 89 Sr, 32 P, 90 Sr/Y, 90 Y, 125 I, 103 Pd, 192 Ir, and 57 Co.
Claim 13
Dependent Claim
40 words
A surgical fastening device according to claim 10, wherein an encapsulating layer of a coherent, biocompatible, and relatively dense material is deposited onto the surface of the surgical fastening device after ion implantation of said radioisotope into said fastening device.
Claim 14
Dependent Claim
34 words
A surgical fastening device according to claim 12, wherein said encapsulating layer comprises a biologically benign material selected from the group consisting of platinum, titanium, gold, palladium, stainless steel, nickel-titanium alloys, silica, and alumina.
Claim 15
Independent Claim
109 words
A method of controlling cellular response to injury at a wound repair site, said method comprising the steps of: a. providing a surgical fastening device for controlling the cellular response to injury, said device including a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site, and a radiation source incorporated into at least a portion of said surgical fastening device to render said device radioactive; and b. implanting said surgical fastening device at or near said wound repair site, wherein said radiation source is selected to deliver a predetermined dose of radiation to said wound repair site over a predetermined period of time.
Claim 16
Independent Claim
109 words
A method of controlling cellular response to injury at a wound repair site, said method comprising the steps of: a. providing a surgical fastening device for controlling the cellular response to injury, said device including a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site, and a radiation source incorporated into at least a portion of said surgical fastening device to render said device radioactive; and b. implanting said surgical fastening device at or near said wound repair site, wherein said radiation source is selected to deliver a predetermined dose of radiation to said wound repair site over a predetermined period of time.
Claim 17
Dependent Claim
28 words
The method of claim 14, wherein said surgical fastening device is selected from the group consisting of sutures, staples, clips, pins, nails, screws, plates, barbs, anchors, and patches.
Claim 18
Dependent Claim
16 words
The method of claim 15, wherein said surgical fastening device is made of a metallic material.
Claim 19
Dependent Claim
17 words
The method of claim 15, wherein said surgical fastening device is made of a substantially non-metallic material.
Claim 20
Dependent Claim
70 words
The method of claim 14, wherein said surgical fastening device is a suture, and further comprising the steps of: c. providing a graft suitable for application to said wound repair site; and d. securing said graft to living tissue at said wound repair site with said suture, wherein a predetermined dose of radiation is delivered to the interface between said graft and said tissue over a predetermined period of time.
Claim 21
Dependent Claim
35 words
The method of claim 14, comprising the further step of: c. removing said surgical fastening device from said wound repair site after said predetermined dose of radiation has been delivered to said wound repair site.
Claim 22
Dependent Claim
27 words
The method of claim 19, comprising the further step of: d. reactivating said device by incorporating another radiation source into at least a portion of said device.
Claim 23
Dependent Claim
82 words
A kit for controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; b) a radiation source incorporated into at least a portion of said surgical fastening device to render said device radioactive; and c) a graft suitable for application to living tissue at said wound repair site, wherein said graft is adapted to be secured to said tissue with said surgical fastening device.
Claim 24
Dependent Claim
82 words
A kit for controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; b) a radiation source incorporated into at least a portion of said surgical fastening device to render said device radioactive; and c) a graft suitable for application to living tissue at said wound repair site, wherein said graft is adapted to be secured to said tissue with said surgical fastening device.
Claim 25
Dependent Claim
29 words
A kit according to claim 21, wherein said surgical fastening device is selected from the group consisting of sutures, staples, clips, pins, nails, screws, plates, barbs, anchors, and patches.
Claim 26
Dependent Claim
17 words
A kit according to claim 22, wherein said surgical fastening device is made of a metallic material.
Claim 27
Dependent Claim
18 words
A kit according to claim 22, wherein said surgical fastening device is made of a substantially non-metallic material.
Claim 28
Dependent Claim
17 words
A kit according to claim 24, wherein said surgical fastening device is made of a polymeric material.
Claim 29
Dependent Claim
18 words
A kit according to claim 24, wherein said surgical fastening device is made of a substantially bioabsorbable material.
Claim 30
Dependent Claim
27 words
A kit according to claim 21, wherein said radiation source comprises a radioisotope which is adapted to be incorporated into said surgical fastening device by ion implantation.
Claim 31
Dependent Claim
37 words
A kit according to claim 27, wherein said radioisotope is selected from the group consisting of 45 Ca, 123 Sn, 89 Sr, 32 P, 90 Sr/Y, 90 Y, 125 I, 103 Pd, 192 Ir, and 57 Co.
Claim 32
Dependent Claim
64 words
A surgical fastening device capable of controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said fastening device to render said device radioactive, wherein the device is made of a substantially bioabsorbable material.
Claim 33
Dependent Claim
64 words
A surgical fastening device capable of controlling cellular response to injury at a wound repair site, comprising: a) a biocompatible surgical fastening device adapted for joining tissue at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said fastening device to render said device radioactive, wherein the device is made of a substantially bioabsorbable material.
Claim 34
Dependent Claim
31 words
A surgical fastening device according to claim 29, wherein said surgical fastening device is selected from the group consisting of sutures, staples, clips, pins, nails, screws, plates, barbs, anchors, and patches.
Claim 35
Dependent Claim
70 words
A surgical tissue joining device, comprising: a) a biocompatible surgical tissue joining structure adapted for holding tissue together at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said tissue joining structure to render said device radioactive, so that the cellular response to injury at the wound repair site is controlled while tissue is held together by the tissue joining device.
Claim 36
Dependent Claim
70 words
A surgical tissue joining device, comprising: a) a biocompatible surgical tissue joining structure adapted for holding tissue together at or near said wound repair site; and b) a radiation source incorporated into at least a portion of said tissue joining structure to render said device radioactive, so that the cellular response to injury at the wound repair site is controlled while tissue is held together by the tissue joining device.
Claim 37
Dependent Claim
32 words
A surgical tissue joining device according to claim 31, wherein said tissue joining device is selected from the group consisting of sutures, staples, clips, pins, nails, screws, plates, barbs, anchors, and patches.
References Cited (Backward Citations)
US2153889A
Cited
US4509506A
Cited
US5059166A
Cited
US5176617A
Cited
US5199939A
Cited
US5199939B1
Cited
US5484384A
Cited
US5354257A
Cited
US5468562A
Cited
US5520664A
Cited
US5302168A
Cited
US5411466A
Cited
US5474797A
Cited
US5492763A
Cited
US5540659A
Cited
US5498227A
Cited
US5503613A
Cited
US5556389A
Cited
US5607442A
Cited
US5709644A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-05-24 | 2002-11-23 | 2003-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-05-24 | 2006-11-23 | 2007-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-05-24 | 2010-11-23 | 2011-05-25 | $7700.00 | Window Closed / Lapsed |