US5900245A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compliant tissue sealants
Assignee: Genzyme Corp
•
Filing: 1996-09-23
•
Granted: 1999-05-04
•
Expires: 2016-09-23
Abstract
Abstract An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
Inventors
- 👤 Amapreet S. Sawhney
- 👤 Michelle D. Lyman
- 👤 Peter K. Jarrett
- 👤 Ronald S. Rudowsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:01
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/06; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61L24/00; A61L24/001; A61L24/0042; A61L24/04; A61L24/046; A61L26/00; A61L26/0009; A61L26/0019; A61L31/08; A61L31/10; A61L31/14; A61L31/148; C; C08; C08G; C08G63/00; C08G63/64; C08G63/66; C08G63/668; C08G63/676; A61K9/1635
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
56 words
A compliant polymeric material on a tissue surface, wherein the material is formed by a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the photopolymerizable groups in an interfacial and bulk manner to form a compliant polymeric material.
Claim 2
Dependent Claim
56 words
A compliant polymeric material on a tissue surface, wherein the material is formed by a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the photopolymerizable groups in an interfacial and bulk manner to form a compliant polymeric material.
Claim 3
Dependent Claim
35 words
The material of claim 1 wherein the compliant material is a hydrogel, wherein the monomer is a photopolymerizable, biodegradable, water-soluble block copolymer comprising photopolymerizable groups, and the polymerization initiator is a free radical polymerization initiator.
Claim 4
Dependent Claim
28 words
The material of claim 1 wherein the polymerized material has an elongation at rupture which is similar to or greater than the elongation of the tissue in vivo.
Claim 5
Dependent Claim
20 words
The material of claim 1 wherein the polymerized material has an elongation at rupture which is greater than about 100%.
Claim 6
Dependent Claim
20 words
The material of claim 1 wherein the polymerized material has an elastic modulus which is less than about 150 kPa.
Claim 7
Dependent Claim
23 words
The material of claim 1 wherein the material has an adherence to the surface of at least about 20 grams per square centimeter.
Claim 8
Dependent Claim
14 words
The material of claim 1 wherein the material further comprises a biologically active material.
Claim 9
Dependent Claim
26 words
The material of claim 1, wherein the normalized compliance ratio of the tissue and the material is in the range of between about 0.05 and 3.
Claim 10
Dependent Claim
15 words
The material of claim 1 wherein the material forms a sealant on a tissue surface.
Claim 11
Dependent Claim
24 words
The material of claim 1 wherein the material adheres two surfaces together, and wherein at least one of the surfaces is a tissue surface.
Claim 12
Dependent Claim
34 words
A kit for the preparation of the compliant material of claim 1, comprising one or more containers each containing one or more of a polymerizable monomer, a priming material and an initiator of polymerization.
Claim 13
Independent Claim
68 words
A method for forming a compliant polymeric material on a tissue surface, the method comprising a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the material on the surface; wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
Claim 14
Independent Claim
68 words
A method for forming a compliant polymeric material on a tissue surface, the method comprising a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the material on the surface; wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
Claim 15
Dependent Claim
16 words
The method of claim 12 wherein the material further forms a sealant on the tissue surface.
Claim 16
Dependent Claim
39 words
The method of claim 13 wherein the monomer is a photopolymerizable, biodegradable, water-soluble block copolymer comprising photopolymerizable groups, and wherein the method comprises photopolymerizing the monomer on the tissue surface in the presence of a free radical polymerization initiator.
Claim 17
Dependent Claim
28 words
The method of claim 12 wherein the polymerized material has an elongation at rupture which is similar to or greater than the elongation of the tissue in vivo.
Claim 18
Dependent Claim
20 words
The method of claim 12 wherein the polymerized material has an elongation at rupture which is greater than about 100%.
Claim 19
Dependent Claim
20 words
The method of claim 12 wherein the polymerized material has an elastic modulus which is less than about 150 kPa.
Claim 20
Dependent Claim
23 words
The method of claim 12 wherein the material has an adherence to the surface of at least about 20 grams per square centimeter.
Claim 21
Dependent Claim
14 words
The method of claim 12 wherein the material further comprises a biologically active material.
Claim 22
Dependent Claim
26 words
The method of claim 12, wherein the normalized compliance ratio of the tissue and the material is in the range of between about 0.05 and 3.
Claim 23
Dependent Claim
59 words
The method of claim 19 wherein the method comprises applying the polymerizable monomer and the biologically active material to the surface of a biological tissue and polymerizing the monomer on the tissue to form a polymeric compliant material on the surface incorporating the biologically active material, wherein the material is capable of controlled release of the biologically active material.
Claim 24
Dependent Claim
41 words
The method of claim 12 wherein the polymerizable monomer is applied to a plurality of surfaces, at least one of said surfaces being a tissue surface, and wherein the polymerization of the material on the surface causes adhering of the surfaces.
Claim 25
Dependent Claim
20 words
The method of claim 13 wherein the compliant polymeric material is formed on the surface of a lung in vivo.
Claim 26
Independent Claim
59 words
A method for forming a compliant polymeric material on a tissue surface, the method comprising: a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the material on the surface; wherein one or both of the polymerization initiators is a redox system.
Claim 27
Independent Claim
59 words
A method for forming a compliant polymeric material on a tissue surface, the method comprising: a) contacting the tissue surface with a polymerization initiator, b) contacting the tissue surface with a solution containing a monomer and a polymerization initiator, and c) polymerizing the material on the surface; wherein one or both of the polymerization initiators is a redox system.
Claim 28
Dependent Claim
13 words
The method of claim 24 wherein the redox system comprises a peroxygen compound.
Claim 29
Dependent Claim
13 words
The method of claim 24 wherein the redox system comprises a metal ion.
Claim 30
Dependent Claim
45 words
The method of claim 26 wherein the metal ion is selected from the group consisting of ferrous ions, ferric ions, cerous ions, ceric ions, cupric ions, cuprous ions, cobaltic ions, cobaltous ions, vanadate V ions, vanadate IV ions, permanganate ions, manganic ions, and manganous ions.
Claim 31
Dependent Claim
15 words
The method of claim 26 wherein the metal ion is a lanthanide or actinide ion.
Claim 32
Dependent Claim
33 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 8,000, about five lactide monomeric units on average and two acrylate groups.
Claim 33
Dependent Claim
33 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 35,000, about four lactide monomeric units on average and two acrylate groups.
Claim 34
Dependent Claim
31 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 8,000, one or more trimethylene carbonate monomeric units on average.
Claim 35
Dependent Claim
33 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 35,000, about 3.3 caprolactan monomeric units on average and two acrylate groups.
Claim 36
Dependent Claim
33 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 35,000, about eighteen lactide monomeric units on average and two acrylate groups.
Claim 37
Dependent Claim
34 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 35,000, about eight trimethylene carbonate monomeric units on average and two acrylate groups.
Claim 38
Dependent Claim
26 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol/polypropylene glycol block, about four trimethylene carbonate monomeric units on average and two acrylate groups.
Claim 39
Dependent Claim
34 words
The material of claim 1 wherein the monomer comprises a polyethylene glycol block with a label average molecular weight of about 20,000, about eight trimethylene carbonate monomeric units on average and two acrylate groups.
Claim 40
Dependent Claim
16 words
The material of claim 1 wherein the monomer comprises one or more trimethylene carbonate monomeric units.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-05-03 | 2002-11-02 | 2003-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-05-03 | 2006-11-02 | 2007-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-05-03 | 2010-11-02 | 2011-05-04 | $7700.00 | Window Closed / Lapsed |