US5480427A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
Assignee: AMS Research LLC
•
Filing: 1994-07-19
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Granted: 1996-01-02
•
Expires: 2014-07-19
Abstract
Abstract The present invention provides a biologically compatible collagenous reaction product comprising ethylenically unsaturated monomerically substituted collagen, the monomeric substituents being essentially free of nitrogen, e.g., methyacrylate, styrene, polyvinyl, ethylene. The collagenous reaction product can be polymerized, e.g., by exposure to UV irradiation, chemical agents or atmospheric oxygen, and molded to form useful medical implant articles. Methods of preparation are also provided.
Inventors
- 👤 Charles D. Kelman
- 👤 Dale P. DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:48
CPC Classifications
C; C08; C08F; C08F289/00; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/16; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
59 words
A shaped soft tissue implant comprising a biocompatible collagenous polymer of collagen modified with a first acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, and maleic anhydride and at least one second acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid.
Claim 2
Dependent Claim
59 words
A shaped soft tissue implant comprising a biocompatible collagenous polymer of collagen modified with a first acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, and maleic anhydride and at least one second acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid.
Claim 3
Dependent Claim
16 words
The shaped soft tissue implant of claim 1, wherein the first acylating agent is glutaric anhydride.
Claim 4
Dependent Claim
20 words
The shaped soft tissue implant of claim 1 wherein said implant is shaped in a form of a blood vessel.
Claim 5
Independent Claim
115 words
A method of preparing a shaped article useful for medical implantation comprising the steps of: contacting solubilized collagen with a first acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, and maleic anhydride and at least one second acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid to form a mixture containing a biocompatible collagenous product; and recovering the biocompatible collagenous product from the mixture; suspending the recovered biocompatible collagenous product in a buffer solution to form a suspension; and polymerizing said suspension in a shaped mold so as to prepare a shaped article useful for medical implantation.
Claim 6
Independent Claim
115 words
A method of preparing a shaped article useful for medical implantation comprising the steps of: contacting solubilized collagen with a first acylating agent selected from the group consisting of glutaric anhydride, succinic anhydride, and maleic anhydride and at least one second acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid to form a mixture containing a biocompatible collagenous product; and recovering the biocompatible collagenous product from the mixture; suspending the recovered biocompatible collagenous product in a buffer solution to form a suspension; and polymerizing said suspension in a shaped mold so as to prepare a shaped article useful for medical implantation.
Claim 7
Dependent Claim
14 words
The method according to claim 4, wherein said first acylating agent is glutaric anhydride.
Claim 8
Independent Claim
94 words
A method for preparing a shaped article useful for medical implantation comprising the steps of: contacting solubilized collagen with an acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid to form a mixture containing a biocompatible collagenous product; and recovering the biocompatible collagenous product from the mixture; suspending the recovered biocompatible collagenous product in a buffer solution to form a suspension; and polymerizing said suspension in a shaped mold so as to prepare a shaped article useful for medical implantation.
Claim 9
Independent Claim
94 words
A method for preparing a shaped article useful for medical implantation comprising the steps of: contacting solubilized collagen with an acylating agent selected from the group consisting of methacrylic anhydride, beta-styrene sulfonyl chloride, ethylene-maleic anhydride copolymer, styrene-maleic anhydride copolymer and poly(vinyl) sulfonic acid to form a mixture containing a biocompatible collagenous product; and recovering the biocompatible collagenous product from the mixture; suspending the recovered biocompatible collagenous product in a buffer solution to form a suspension; and polymerizing said suspension in a shaped mold so as to prepare a shaped article useful for medical implantation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-01-01 | 1999-07-03 | 2000-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-01-01 | 2003-07-03 | 2004-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-01-01 | 2007-07-03 | 2008-01-02 | $7700.00 | Window Closed / Lapsed |