US4303066A
Expired / Lapsed
US
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Burn dressing
Assignee: National Patent Development Corp
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Filing: 1979-06-28
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Granted: 1981-12-01
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Expires: 1999-06-28
Abstract
Abstract A two package system useful in forming a rapid plastic film, i.e., a burn dressing or burn bandage, on the burn of the skin. One package contains particulate hydrophilic polymer such as 2-hydroxyethyl methacrylate polymer and the other package contains a liquid mixture of an inert, high boiling, organic liquid and water desirably in a weight ratio of 70:30 to 30:70. The particulate polymer and liquid mixture are desirably applied to the burn simultaneously, or by first applying the liquid mixture followed by application of the polymer. A plastic film, burn dressing, can result in a few minutes.
Inventors
- 👤 Mark J. D'Andrea
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:49
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0009; A61L26/0014; A61L26/0052
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
98 words
A two-package system useful in forming a non-tacky, non-toxic, non-stinging plastic burn dressing directly on the wound of the skin which consists essentially of: (a) a first package containing particulate hydrophilic polymer having the following characteristics: lower-alkanol insolubility, water-swellability, water-insolubility, and a molecular weight above about 50,000; and (b) a second package used with said first package and containing liquid comprised of from 20 to 80 weight percent water and from 80 to 20 weight percent of an inert organic liquid, said organic liquid being characterized by a boiling point of at least about 120° C. and water-miscibility.
Claim 2
Dependent Claim
98 words
A two-package system useful in forming a non-tacky, non-toxic, non-stinging plastic burn dressing directly on the wound of the skin which consists essentially of: (a) a first package containing particulate hydrophilic polymer having the following characteristics: lower-alkanol insolubility, water-swellability, water-insolubility, and a molecular weight above about 50,000; and (b) a second package used with said first package and containing liquid comprised of from 20 to 80 weight percent water and from 80 to 20 weight percent of an inert organic liquid, said organic liquid being characterized by a boiling point of at least about 120° C. and water-miscibility.
Claim 3
Dependent Claim
89 words
The two-package system of claim 1 wherein the concentration of particulate hydrophilic polymer to liquid is at least sufficient to form a non-tacky plastisol film onto the skin; wherein said polymer is characterized by at least 50 mol percent of the following recurring unit: ##STR2## wherein R is hydrogen or methyl, wherein R 1 is C 2 -C 4 alkylene, and wherein R 2 is hydrogen, C 1 -C 4 alkyl or C 1 -C 4 alkoxyC 1 -C 4 alkyl; and wherein said organic liquid is a glycol.
Claim 4
Dependent Claim
47 words
The two-package system of claim 2 wherein said polymer is characterized by a bulk density of at least about 0.6 gram/cc and wherein said organic liquid is characterized by a plurality of oxyethylene units in the molecule and a boiling point of at least about 200° C.
Claim 5
Dependent Claim
37 words
The two-package system of claim 3 wherein said polymer is characterized by at least 80 mol percent of the recurring unit and wherein the organic liquid is a oxyethylene polymer having a molecular weight up to 2000.
Claim 6
Dependent Claim
32 words
The two-package system of claim 2 wherein said second package contains a liquid comprised of from 30 to 70 weight percent water and from 70 to 30 weight percent inert organic liquid.
Claim 7
Dependent Claim
23 words
The two-package system of claim 4 wherein said polymer is a polymer of 2-hydroxyethyl methacrylate and wherein said organic liquid is polyethylene glycol.
Claim 8
Dependent Claim
32 words
The two-package system of claim 6 wherein said second package contains a liquid comprised of from 30 to 70 weight percent water and from 70 to 30 weight percent inert organic liquid.
Claim 9
Dependent Claim
21 words
The two-package system of claim 7 wherein said organic liquid is polyethylene glycol having a molecular weight of 150 to 800.
Claim 10
Dependent Claim
29 words
The two-package system of claim 8 wherein said organic liquid is polyethylene glycol having a molecular weight of about 400 and wherein said polymer is a three-dimensional poly(2-hydroxyethyl methacrylate).
Claim 11
Dependent Claim
93 words
A non-tacky, non-irritating, innocuous, non-stinging, pinhole-free burn dressing which comprises a plastisol formed by contacting a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic vehicle which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; with a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility, (ii) water-insolubility, (iii) water-swellability, and (iv) an average molecular weight of at least about 50,000; the concentration of said polymer to said vehicle being at least sufficient to form a non-tacky plastisol.
Claim 12
Dependent Claim
93 words
A non-tacky, non-irritating, innocuous, non-stinging, pinhole-free burn dressing which comprises a plastisol formed by contacting a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic vehicle which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; with a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility, (ii) water-insolubility, (iii) water-swellability, and (iv) an average molecular weight of at least about 50,000; the concentration of said polymer to said vehicle being at least sufficient to form a non-tacky plastisol.
Claim 13
Dependent Claim
74 words
The burn dressing of claim 10 wherein said liquid organic vehicle is characterized by a boiling point above about 200° C. and a plurality of oxyethylene units in the molecule; and wherein said polymer is a polymer of a hydroxy lower alkyl acrylate or methacrylate, of a hydroxy lower alkoxy lower alkyl acrylate or methacrylate, of acrylamide, of methacrylamide, of a N-lower alkylacrylamide or methacrylamide, of N,N-di-lower alkylacrylamide or methacrylamide, or of an N-vinylpyrrolidone.
Claim 14
Dependent Claim
49 words
The burn dressing of claim 11 wherein said liquid comprises 30 to 70 weight percent water and 70 to 30 weight percent organic vehicle which is a polyethylene glycol having an average molecular weight up to about 800, and wherein said particulate polymer is a polymer of 2-hydroxyethyl methacrylate.
Claim 15
Dependent Claim
28 words
The burn dressing of claim 12 wherein said particulate polymer has an average molecular weight greater than 250,000 and a bulk density of at least about 0.6 gram/cc.
Claim 16
Dependent Claim
106 words
In combination, a burned tissue surface and in contact therewith a non-tacky, non-irritating, innocuous, non-stinging, pinhole-free burn dressing therefor, said burn dressing comprising a plastisol formed by contacting a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic vehicle which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; with a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility, (ii) water-insolubility, (iii) water-swellability, and (iv) an average molecular weight of at least about 50,000; the concentration of said polymer to said vehicle being at least sufficient to form a non-tacky plastisol.
Claim 17
Dependent Claim
106 words
In combination, a burned tissue surface and in contact therewith a non-tacky, non-irritating, innocuous, non-stinging, pinhole-free burn dressing therefor, said burn dressing comprising a plastisol formed by contacting a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic vehicle which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; with a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility, (ii) water-insolubility, (iii) water-swellability, and (iv) an average molecular weight of at least about 50,000; the concentration of said polymer to said vehicle being at least sufficient to form a non-tacky plastisol.
Claim 18
Dependent Claim
66 words
The combination of claim 14 wherein said liquid organic vehicle is characterized by a boiling point above about 200° C. and a plurality of oxyethylene units in the molecule; and wherein said polymer is characterized by a bulk density of at least about 0.6 gram/cc; the concentration of said polymer to said vehicle being in the range of from about 2:3 to about 3:1 by weight.
Claim 19
Dependent Claim
69 words
The combination of claim 15 wherein said liquid comprises 30 to 70 weight percent water and 70 to 30 weight percent organic vehicle which is a polyethylene glycol having an average molecular weight up to about 800, wherein said particulate polymer is a polymer of 2-hydroxyethyl methacrylate and wherein the weight ratio of said polymer to said liquid is in the range of from about 1:1 to about 2:1.
Claim 20
Dependent Claim
127 words
A process of treating a burned tissue surface comprising applying to the burned surface (1) a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic liquid which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; (2) a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility (ii) water-insolubility, (iii) water-swellability, and (iv) a moecular weight of at least about 50,000; allowing said liquid vehicle to solvate said polymer in situ on the burned surface to form a gelled, non-tacky, innocuous, non-stinging, plastisol burn dressing which prevents infection of the burn by microorganisms; (3) the weight ratio of said polymer to said liquid which forms the burning dressing being from 2:3 to 3:1.
Claim 21
Dependent Claim
127 words
A process of treating a burned tissue surface comprising applying to the burned surface (1) a liquid comprised of 20 to 80 weight percent water and 80 to 20 weight percent organic liquid which (i) is non-toxic and (ii) is characterized by a boiling point of at least about 120° C.; (2) a particulate hydrophilic polymer characterized by (i) lower-alkanol solubility (ii) water-insolubility, (iii) water-swellability, and (iv) a moecular weight of at least about 50,000; allowing said liquid vehicle to solvate said polymer in situ on the burned surface to form a gelled, non-tacky, innocuous, non-stinging, plastisol burn dressing which prevents infection of the burn by microorganisms; (3) the weight ratio of said polymer to said liquid which forms the burning dressing being from 2:3 to 3:1.
Claim 22
Dependent Claim
19 words
The process according to claim 17 wherein (1) and (2) are applied substantially simultaneously to the debrided burned surface.
Claim 23
Dependent Claim
35 words
The process according to claim 17 wherein said liquid is applied first to the burn surface and then said polymer is applied on the liquid coating and is allowed to solvate to form a film.
Claim 24
Dependent Claim
22 words
The process according to claim 17 wherein the burn surface is of at least the debrided condition of a second degree burn.
Claim 25
Dependent Claim
68 words
The process according to claim 17 wherein said liquid organic vehicle is characterized by a boiling point above about 200° C. and a plurality of oxyethylene units in the molecule; and wherein said polymer is characterized by a bulk density of at least about 0.6 gram/cc; the weight ratio of said polymer to said vehicle being in the range of from about 1:1 to about 2:1 by weight.
Claim 26
Dependent Claim
33 words
The process according to claim 21 wherein said liquid organic vehicle is polyethylene glycol having an average molecular weight up to about 800, and said particulate polymer is a polymer of 2-hydroxyethyl methacrylate.
Claim 27
Dependent Claim
28 words
The process according to claim 22 wherein said particulate polymer has an average molecular weight greater than 250,000 and a bulk density of at least about 0.7 gram/cc.
Claim 28
Dependent Claim
54 words
A process of treating a debrided burned tissue surface consisting essentially of applying to said debrided burned surface the liquid and hydrophilic polymer of claim 22 and allowing the liquid to solvate said polymer in situ on the burned surface to form a gelled burn dressing which prevents infection of the burn by microorganisms.
Claim 29
Dependent Claim
11 words
A burn dressing consisting essentially of the composition of claim 24.
Claim 30
Dependent Claim
28 words
The process of claim 17 wherein (1) and (2) are applied to the surface of a burn ranging from a third degree burn to a fourth degree burn.
Claim 31
Dependent Claim
13 words
The process of claim 26 wherein the burn is a third degree burn.
Claim 32
Dependent Claim
23 words
The process of claim 21 wherein the burned surface is a burn ranging from a third degree burn to a fourth degree burn.
Claim 33
Dependent Claim
34 words
The process of claim 17 wherein the vehicle is polyethylene glycol molecular weight about 400 and the polymer is a three-dimensional polymer of 2-hydroxyethyl methacrylate having a bulk density at least about 0.6 gram/cc.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-30 | 1985-06-01 | 1985-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-30 | 1989-06-01 | 1989-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-30 | 1993-06-01 | 1993-12-01 | $7700.00 | Window Closed / Lapsed |