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US5846931A
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Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide and methods of inducing cartilage by administration of same
Assignee: Genetics Institute LLC
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Filing: 1997-09-10
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Granted: 1998-12-08
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Expires: 2017-09-10
Abstract
Abstract Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor-β (TGF-β) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
Inventors
- 👤 Gary Hattersley
- 👤 Vicki A. Rosen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:15
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/29; A61K38/18; A61P; A61P19/00; A61P19/02; A61P19/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
57 words
A composition comprising: (a) a member selected from the group consisting of the transforming growth factor-β (TGF-β) superfamily; and (b) a truncated parathyroid hormone related peptide (PTHrP) comprising amino acids 1 to 34 of PTHrP; said composition having the activity of inducing the formation or maintenance of cartilaginous tissue in a patient when administered to said patient.
Claim 2
Dependent Claim
57 words
A composition comprising: (a) a member selected from the group consisting of the transforming growth factor-β (TGF-β) superfamily; and (b) a truncated parathyroid hormone related peptide (PTHrP) comprising amino acids 1 to 34 of PTHrP; said composition having the activity of inducing the formation or maintenance of cartilaginous tissue in a patient when administered to said patient.
Claim 3
Dependent Claim
33 words
The composition of claim 1, wherein its member of (a) is a bone morphogenic protein (BMP) is selected from the group consisting of BMP-1, BMP-3, BMP-6, BMP-8, BMP-9, BMP-10, BMP-11, BMP-14 and BMP-15.
Claim 4
Dependent Claim
23 words
The composition of claim 2, wherein said composition further comprises a member selected from the group consisting of the BMP family of proteins.
Claim 5
Dependent Claim
28 words
A method for inducing the formation or maintenance of cartilaginous tissue in a patient, comprising administering to the patient an effective amount of the composition of claim 1.
Claim 6
Dependent Claim
13 words
A method according to claim 4, wherein the patient is suffering from arthritis.
Claim 7
Dependent Claim
18 words
A method according to claim 4, wherein the patient is suffering from an articular cartilage defect or damage.
Claim 8
Dependent Claim
23 words
A method for inducing cartilaginous tissue formation, growth, differentiation, proliferation, and maintenance comprising administering an effective amount of a composition of claim 1.
References Cited (Backward Citations)
US5013649A
Cited
US5106748A
Cited
US5108922A
Cited
US5116738A
Cited
US5141905A
Cited
US5187076A
Cited
US5457092A
Cited
US5455329A
Cited
US5457047A
Cited
WO1991018098A1
Cited
WO1993000050A1
Cited
WO1993000432A1
Cited
WO1993009229A1
Cited
WO1993016099A2
Cited
WO1994001557A1
Cited
WO1994015966A1
Cited
WO1994015965A1
Cited
WO1994015949A1
Cited
WO1994021681A1
Cited
WO1994026892A1
Cited
WO1994026893A1
Cited
WO1995001801A1
Cited
WO1995001802A1
Cited
WO1995016035A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-12-07 | 2002-06-08 | 2002-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-12-07 | 2006-06-08 | 2006-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-12-07 | 2010-06-08 | 2010-12-08 | $7700.00 | Window Closed / Lapsed |