Patent US5837278A successfully refreshed from Google Patents.
US5837278A
Expired / Lapsed
US
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Resorbable collagen membrane for use in guided tissue regeneration
Assignee: Geistlich Pharma AG
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Filing: 1995-01-04
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Granted: 1998-11-17
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Expires: 2015-01-04
Abstract
Abstract The invention is concerned with wound healing and in particular with the use of a collagen-containing membrane in guided tissue regeneration. The invention provides a resorbable collagen membrane for use in guided tissue regeneration wherein one face of the membrane is fibrous thereby allowing cell growth thereon and the opposite face of the membrane is smooth, thereby inhibiting cell adhesion thereon.
Inventors
- 👤 Peter Geistlich
- 👤 Zdenek Eckmayer
- 👤 Philip Boyne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:39
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A01; A01N; A01N25/00; A01N25/34; A61K; A61K35/00; A61K35/12; A61K35/34; A61K35/37; A61K35/48; A61K35/50; A61L15/28; A61L15/40; A61L15/42; A61L15/44; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/36; A61L27/3604; A61L27/3683; A61L27/50; A61L27/54; A61L31/00; A61L31/005; A61L31/04; A61L31/043; A61L31/044; A61L31/08; A61L31/10; A61L31/14; A61L31/16; C; C08; C08L; C08L5/00; C08L5/08; A61L2300/00; A61L2300/40; A61L2300/404
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
76 words
A resorbable collagen membrane for use in guided tissue regeneration comprising a substantially purified collagen membrane which is physiologically acceptable for implant into a mammalian body, and which is at least about 95% by weight native collagen, wherein a first face of said membrane is fibrous thereby allowing cell growth thereon and an opposite face of said membrane is smooth, thereby inhibiting cell adhesion thereon and acts as a barrier to prevent passage of cells therethrough.
Claim 2
Dependent Claim
76 words
A resorbable collagen membrane for use in guided tissue regeneration comprising a substantially purified collagen membrane which is physiologically acceptable for implant into a mammalian body, and which is at least about 95% by weight native collagen, wherein a first face of said membrane is fibrous thereby allowing cell growth thereon and an opposite face of said membrane is smooth, thereby inhibiting cell adhesion thereon and acts as a barrier to prevent passage of cells therethrough.
Claim 3
Dependent Claim
15 words
A membrane as claimed in claim 1 which is derived from a natural collagen membrane.
Claim 4
Dependent Claim
18 words
A membrane as claimed in claim 2 derived from mammalian peritoneum or pericardeum, placenta membrane or basal membrane.
Claim 5
Dependent Claim
14 words
A membrane as claimed in claim 3 which is derived from calves or piglets.
Claim 6
Dependent Claim
15 words
A membrane as claimed in claim 4 which is derived from 6-7 week old piglets.
Claim 7
Dependent Claim
13 words
A membrane as claimed in claim 1 which is substantially free from fat.
Claim 8
Dependent Claim
18 words
A membrane as claimed in claim 1 which has a thickness of 0.1 to 1.0 mm when dry.
Claim 9
Dependent Claim
16 words
A membrane as claimed in claim 1 in which the collagen is cross-linked without becoming non-resorbable.
Claim 10
Dependent Claim
30 words
A membrane as claimed in claim 1 in which said first face is on a fibrous side of said membrane, and wherein the fibrous side is impregnated with a glycosaminoglycan.
Claim 11
Dependent Claim
17 words
A membrane as claimed in claim 9 in which the fibrous side is impregnated with hyaluronic acid.
Claim 12
Dependent Claim
32 words
A membrane as claimed in claim 9 in which the fibrous side is impregnated with a member selected from the group consisting of chondroitin sulphate, dermatan sulphate, keratan sulphate and mixtures thereof.
Claim 13
Dependent Claim
19 words
A membrane as claimed in claim 9 in which the membrane contains 0.1 to 30.0% by weight of glycosaminoglycan.
Claim 14
Dependent Claim
12 words
A membrane as claimed in claim 1 containing at least one pharmaceutical.
Claim 15
Dependent Claim
9 words
A membrane as claimed in claim 13 containing taurolidine.
Claim 16
Dependent Claim
50 words
A method of treating a wound or lesion of a human or non-human animal body comprising application of a membrane as claimed in claim 1 to the wound or lesion, said membrane being so oriented that the fibrous face of the membrane faces an area where tissue regeneration is required.
Claim 17
Dependent Claim
14 words
A method as claimed in claim 15 in which the said tissue is bone.
Claim 18
Dependent Claim
18 words
A method as claimed in claim 16 in which the wound or lesion is in an orofacial region.
Claim 19
Dependent Claim
71 words
A method of preparing a membrane as claimed in claim 1 in which a mammalian collagen membrane having a smooth face and a fibrous side having a fibrous face is subjected to treatment with alkali to saponify fats and eliminate alkali sensitive substances and then acidified to eliminate acid sensitive substances, followed by washing, drying, and degreasing, whereby to form a membrane comprising at least about 95% by weight native collagen.
Claim 20
Dependent Claim
20 words
A method as claimed in claim 18 in which, a glycosaminoglycan is impregnated into the fibrous side of said membrane.
Claim 21
Independent Claim
63 words
A method of guided tissue regeneration comprising application of a resorbable collagen membrane to an orofacial region of a human or non-human animal body, wherein a first face of said membrane is fibrous thereby allowing cell growth thereon and an opposite face of said membrane is smooth, thereby inhibiting cell adhesion thereon and acts as a barrier to prevent passage of cells therethrough.
Claim 22
Independent Claim
63 words
A method of guided tissue regeneration comprising application of a resorbable collagen membrane to an orofacial region of a human or non-human animal body, wherein a first face of said membrane is fibrous thereby allowing cell growth thereon and an opposite face of said membrane is smooth, thereby inhibiting cell adhesion thereon and acts as a barrier to prevent passage of cells therethrough.
Claim 23
Dependent Claim
19 words
A method as claimed in claim 20 wherein said membrane comprises at least about 95% by weight native collagen.
Claim 24
Dependent Claim
13 words
A method as claimed in claim 20 in which the tissue is bone.
Claim 25
Dependent Claim
15 words
A method as claimed in claim 18 further including the step of cross-linking said membrane.
Claim 26
Dependent Claim
17 words
A membrane as claimed in claim 12, in which said membrane contains 2-10% by weight said glycosaminoglycan.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-16 | 2002-05-18 | 2002-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-16 | 2006-05-18 | 2006-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-16 | 2010-05-18 | 2010-11-17 | $7700.00 | Window Closed / Lapsed |