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US5807306A
Expired / Lapsed
US
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Polymer matrix drug delivery apparatus
Assignee: Mmc/gatx Partnership No1
•
Filing: 1994-08-16
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Granted: 1998-09-15
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Expires: 2014-08-16
Abstract
Abstract A drug delivery apparatus and method for delivering a drug locally to internal body tissue using a catheter device including a polymer matrix containing a drug. The drug is actively transported from the polymer matrix to the internal body tissue using iontophoresis or phonophoresis. In addition, the polymer matrix can be expanded to promote intimate contact with the walls of a passageway or vessel.
Inventors
- 👤 J. Edward Shapland
- 👤 Keith R. Hildelbrand
- 👤 Joel R. Racchini
- 👤 Jin Shimada
- 👤 Mark B. Knudson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:03
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/104; A61M37/00; A61M37/0092; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61N1/306; A61N1/32; A61N1/325; A61M25/1011; A61M2025/1013; A61M2025/1043; A61M2025/105; A61M2210/00; A61M2210/16; A61M2210/167
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
92 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having an elongated body; a polymer matrix operably connected to and coaxially aligned with the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.
Claim 2
Independent Claim
92 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having an elongated body; a polymer matrix operably connected to and coaxially aligned with the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.
Claim 3
Dependent Claim
12 words
The apparatus of claim 1 wherein the transport means comprises iontophoresis means.
Claim 4
Dependent Claim
40 words
The apparatus of claim 2 wherein the iontophoresis means comprises at least two electrodes configured to be placed in electrical communication with a power supply; at least one of the electrodes being positioned for electrical communication with the polymer matrix.
Claim 5
Dependent Claim
26 words
The apparatus of claim 3 wherein the plurality of electrodes comprises first and second electrodes, the first and second electrodes being operably connected to the catheter.
Claim 6
Dependent Claim
10 words
The apparatus of claim 1 wherein the catheter is flexible.
Claim 7
Dependent Claim
19 words
The apparatus of claim 1 wherein the elongated body has a circumference and the polymer matrix circumscribes the circumference.
Claim 8
Independent Claim
115 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having an elongated body; a polymer matrix operably connected to the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene polyetheline oxide, polyacrylamide, polyurethane rubber, and natural rubber; expansion means operably connected to the elongated body, the expansion means being configured to expand the polymer matrix in a direction substantially radial to the catheter; and transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.
Claim 9
Independent Claim
115 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having an elongated body; a polymer matrix operably connected to the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene polyetheline oxide, polyacrylamide, polyurethane rubber, and natural rubber; expansion means operably connected to the elongated body, the expansion means being configured to expand the polymer matrix in a direction substantially radial to the catheter; and transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.
Claim 10
Dependent Claim
12 words
The apparatus of claim 7 wherein the expansion means comprises a balloon.
Claim 11
Independent Claim
87 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having a balloon; a polymer matrix operably connected to the balloon, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and first and second electrodes configured to be placed in electrical communication to a power supply, the first electrode being positioned for electrical communication with the polymer matrix.
Claim 12
Independent Claim
87 words
An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising: a catheter having a balloon; a polymer matrix operably connected to the balloon, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and first and second electrodes configured to be placed in electrical communication to a power supply, the first electrode being positioned for electrical communication with the polymer matrix.
Claim 13
Dependent Claim
15 words
The apparatus of claim 9 wherein the second electrode is operatively connected to the catheter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-09-14 | 2002-03-16 | 2002-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-09-14 | 2006-03-16 | 2006-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-09-14 | 2010-03-16 | 2010-09-15 | $7700.00 | Window Closed / Lapsed |