Myocardial iontophoresis

Claim 2

An implantable iontophoretic delivery system for use in applying medicinal materials rapidly to specific tissue sites of interest comprising: a source of electrical current; pulse generating means associated with the source of electric current for generating a series of electric current pulses; first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current, wherein the first electrode further includes means adapted to receive, contain and dispense medicinal materials from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses supplied from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode to cause infusion of the medicinal material in the desired direction; storage means for storing a supply of the medicinal materials; conduit means connecting the storage means with the first electrode; pump means for supplying an amount of the medicinal materials from the storage means to the first electrode on demand; circuit means connected to the source for supplying current pulses generated by the pulse generating means to the electrodes; condition sensing means for sensing medical conditions in the tissue of interest requiring application of the medicinal materials to the tissue of interest; and control means for activating and deactivating the pump means and pulse generating means in response to sensed conditions.

Claim 3

The apparatus of claim 1 wherein the tissue of interest is an arrhythmogenic site of infarcted heart tissue, the electrodes are defibrillator patch electrodes and the medicinal material is an antiarrhythmic drug.

Claim 4

The apparatus of claim 1 wherein the first electrode further comprises an inlet for receiving medicinal materials connected via the conduit means to the storage means, a storage chamber separated from the tissue by a permeable membrane through which the medicinal material can be infused and a discharge port connected with the storage means through which unused medicinal material can be secreted.

Claim 5

An implantable iontophoretic delivery system for use in applying cardiac medications rapidly to specific arrhythmogenic heart tissue sites of interest in conjunction with the operation of an automatic implantable cardioverter/defibrillator (AICD) comprising: a source of electrical current; pulse generating means associated with the source of electrical current for generating electric current pulses; first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current for the implantable defibrillator, wherein the first electrode further includes means adapted to receive, contain and dispense cardiac medication from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode in the infusion of medication as desired; storage means for storing a supply of cardiac medication; conduit means connecting the storage means with the first electrode; pump means for supplying an amount of the medication from the storage means to the first electrode on demand; circuit means connected to the source of electrical current for supplying defibrillating current pulses from the pulse generating means and a series of cardiac medication infusing current pulses from the pulse generating means to the electrodes; condition sensing means for sensing medical conditions in the tissue of interest requiring defibrillation and/or application of the cardiac medication to the tissue of interest; and control means for activating and deactivating the pump means and both the defibrillation and/or the medicating infusing pulsing in response to sensed conditions or in fixed interval form.

Claim 6

An implantable iontophoretic delivery system for use in applying cardiac medications rapidly to specific arrhythmogenic heart tissue sites of interest in conjunction with the operation of an automatic implantable cardioverter/defibrillator (AICD) comprising: a source of electrical current; pulse generating means associated with the source of electrical current for generating electric current pulses; first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current for the implantable defibrillator, wherein the first electrode further includes means adapted to receive, contain and dispense cardiac medication from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode in the infusion of medication as desired; storage means for storing a supply of cardiac medication; conduit means connecting the storage means with the first electrode; pump means for supplying an amount of the medication from the storage means to the first electrode on demand; circuit means connected to the source of electrical current for supplying defibrillating current pulses from the pulse generating means and a series of cardiac medication infusing current pulses from the pulse generating means to the electrodes; condition sensing means for sensing medical conditions in the tissue of interest requiring defibrillation and/or application of the cardiac medication to the tissue of interest; and control means for activating and deactivating the pump means and both the defibrillation and/or the medicating infusing pulsing in response to sensed conditions or in fixed interval form.

Claim 7

The apparatus of claim 4 wherein the electrodes are defibrillator patch electrodes and the cardiac medication is an antiarrhythmic drug.

Claim 8

The apparatus of claim 5 wherein the first electrode further comprises an inlet for receiving medication from the storage means via the conduit means, a storage chamber connected to the inlet and separated from the tissue by a permeable membrane through which the cardiac medication can be infused and a discharge port through which unused medication can be secreted.

Claim 11

The method of claim 7 wherein the benign electrical current pulses are applied during ventricular refractory periods.