US4689041A
Expired / Lapsed
US
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Retrograde delivery of pharmacologic and diagnostic agents via venous circulation
Assignee: Heartport Inc
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Filing: 1985-10-09
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Granted: 1987-08-25
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Expires: 2005-10-09
Abstract
Abstract This invention is directed to specific methods and a system for the retrograde delivery of fluids containing a pharmacologic or diagnostic agent (via a catheter inserted into a patient's regional venous system) supplied into the microcirculatory system of the same region to which the arterial blood in flow is blocked or otherwise restricted. A catheter having an inflatable balloon on the distal end thereof is passed through the patient's venous system (e.g., for myocardial retroinfusion, and so that fluid containing pharmacologic (thrombolytic drugs or antiarrhythmic agents) or diagnostic agents is directed therethrough in a direction opposite to the normal blood flow and into the microcirculatory system of the jeopardized tissue. The fluid is held in the microcirculation for a period and at a pressure which facilitates its absorption or other function such as clot dissolution, pharmacologic action, or diagnostic contrast assessment with minimally invasive imaging methods. The balloon is then deflated after a particular treatment period, or else retroinfusion is reduced or terminated whenever the fluid pressure in the regional vein exceeds a predetermined maximal pressure which could lead to tissue damage. For coronary venous retroinfusion, the catheter tip balloon when inflated has preferably a broad base and tapers in the distal direction to the apex thereof.
Inventors
- 👤 Eliot Corday
- 👤 Samuel Meerbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:23
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/1002; A61M2025/1043; A61M2025/1052
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
214 words
A method for the retrograde venous delivery of fluid containing pharmacologic or diagnostic agents to a microcirculatory system in a desired location within a patient's body comprising: a. inserting a catheter having an inflatable balloon at the distal end thereof into the patient's venous system and advancing the catheter to a position within a vein which drains the microcirculatory system; b. inflating the balloon at the distal end of the catheter to thereby block the interior of the vein and prevent fluid from flowing through the vein in the same direction as normal blood flow; c. directing the fluid containing pharmacologic or diagnostic agents through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough; d. maintaining the fluid containing pharmacologic or diagnostic agents in the microcirculatory system for a period of time of at least two seconds and at sufficient pressure to facilitate the delivery of the fluid in an unsynchronized manner to the desired location and the desired performance of the pharmacologic or diagnostic agents contained therein; and e. deflating the balloon at the distal end of the catheter to allow fluid to drain from the microcirculatory system through the vein in the direction of normal blood flow therein.
Claim 2
Independent Claim
214 words
A method for the retrograde venous delivery of fluid containing pharmacologic or diagnostic agents to a microcirculatory system in a desired location within a patient's body comprising: a. inserting a catheter having an inflatable balloon at the distal end thereof into the patient's venous system and advancing the catheter to a position within a vein which drains the microcirculatory system; b. inflating the balloon at the distal end of the catheter to thereby block the interior of the vein and prevent fluid from flowing through the vein in the same direction as normal blood flow; c. directing the fluid containing pharmacologic or diagnostic agents through the catheter and the vein and into the microcirculatory system in a retrograde direction which is opposite to the normal blood flow therethrough; d. maintaining the fluid containing pharmacologic or diagnostic agents in the microcirculatory system for a period of time of at least two seconds and at sufficient pressure to facilitate the delivery of the fluid in an unsynchronized manner to the desired location and the desired performance of the pharmacologic or diagnostic agents contained therein; and e. deflating the balloon at the distal end of the catheter to allow fluid to drain from the microcirculatory system through the vein in the direction of normal blood flow therein.
Claim 3
Dependent Claim
33 words
The method of claim 1, wherein the fluid containing the pharmacologic or diagnostic agent is held in the microcirculatory system for a minimum period of from about 2 seconds to about 10 minutes.
Claim 4
Dependent Claim
36 words
The method of claim 1, wherein the distal end of the catheter is inserted into the patient's coronary sinus to instill the fluid containing pharmacologic or diagnostic agents to a microcirculatory system in the patient's myocardium.
Claim 5
Dependent Claim
24 words
The method of claim 3, wherein the inflated balloon at the distal end of the catheter has a broad base and a tapered apex.
Claim 6
Dependent Claim
15 words
The method of claim 4, wherein the inflated balloon has the shape of an acorn.
Claim 7
Dependent Claim
30 words
The method of claim 4, wherein the distal end of the catheter is positioned within the coronary sinus so that the inflated balloon does not obstruct the middle cardiac vein.
Claim 8
Dependent Claim
39 words
The method of claim 3, wherein the fluid delivered to the microcirculatory system contains one or more pharmacologic agents selected from the group consisting of antiarrhythmic drugs, spasmolytic drugs, thrombolytic drugs, anti-inflammatory drugs, inotropic drugs, vasodilating drugs, cardioplegic drugs.
Claim 9
Dependent Claim
39 words
The method of claim 7, wherein the fluid contains one or more drugs selected from the group consisting of prostaglandins, mannitol, streptokinase, lidocaine, procainamide, verapamil, propranolol, disopyramide, amiodarone, cardiazem, nifedipine, dipyridamole, novocaine, aminophyllin, digitalis, catecholamines, steriods, and glucose-insulin-potassium mixtures.
Claim 10
Dependent Claim
21 words
The method of claim 3, wherein the fluid contains a diagnostic contrast agent employed for aniography, radionuclide imaging or echocardiographic imaging.
Claim 11
Dependent Claim
30 words
The method of claim 3, wherein fluid is directed through the catheter, the coronary sinus and into the microcirculatory system in the patient's myocardium when the heart is in diastole.
Claim 12
Dependent Claim
41 words
The method of claim 1, wherein the inflated balloon at the distal end fo the catheter is deflated when the fluid pressure exceeds a predetermined maximum to allow fluid drainage through the vein in the normal direction thereby relieving excessive pressure.
Claim 13
Dependent Claim
40 words
The method of claim 1, wherein after fluid has been maintained in the microcirculatory system for at least about two seconds, the fluid pressure in the catheter is released to deflate the inflated balloon to allow for normal venous drainage.
Claim 14
Dependent Claim
17 words
The method of claim 12, wherein the period for normal venous drainage is at least 5 minutes.
References Cited (Backward Citations)
US1282881A
Cited
US3766924A
Cited
US3833003A
Cited
US4154227A
Cited
US4284073A
Cited
US4493697A
Cited
US4351341A
Cited
US4531936A
Cited
US4459977A
Cited
US4535757A
Cited
US4512762A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-24 | 1991-02-23 | 1991-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-24 | 1995-02-23 | 1995-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-24 | 1999-02-23 | 1999-08-25 | $7700.00 | Window Closed / Lapsed |