Patent US2184328A successfully refreshed from Google Patents.
Patent US5616254A successfully refreshed from Google Patents.
US5616254A
Expired / Lapsed
US
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System and method for processing biological fluid
Assignee: Pall Corp
•
Filing: 1995-05-26
•
Granted: 1997-04-01
•
Expires: 2015-05-26
Abstract
Abstract A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
- 👤 Vlado I. Matkovich
- 👤 Thomas Bormann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:33
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/087; A; A61; A61J; A61J1/00; A61J1/05; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/025; A61M1/029; A61M1/34; A61M1/3472; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B01D61/00; B01D61/14; B01D61/145; B01D61/147; B01D61/16; B01D61/20; B01D61/22; B01D65/00; B01D65/08; A61J1/10; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M5/148; A61M5/1483; A61M5/1486; B01D2321/00; B01D2321/20; B01D2321/2083
Claims Analysis
Total Claims: 71
Claim 1
Independent Claim
132 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, a first gas inlet comprising at least one porous medium for passing gas therethrough, interposed between the first container and the first porous medium, or interposed between the first container and the second porous medium.
Claim 2
Dependent Claim
132 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, a first gas inlet comprising at least one porous medium for passing gas therethrough, interposed between the first container and the first porous medium, or interposed between the first container and the second porous medium.
Claim 3
Dependent Claim
50 words
The system of claim 1, further comprising a second gas inlet, said first gas inlet interposed between the first container and the first porous medium for passing biological fluid therethrough; and said second gas inlet interposed between the first container and the second porous medium for passing biological fluid therethrough.
Claim 4
Dependent Claim
17 words
The system of claim 1 further comprising an additional container in fluid communication with the second container.
Claim 5
Dependent Claim
10 words
The system of claim 1 comprising a closed sterile system.
Claim 6
Dependent Claim
28 words
The system of claim 1 wherein the gas inlet includes at least one porous medium that allows gas to pass therethrough but prevents the passage of bacteria therethrough.
Claim 7
Dependent Claim
23 words
The system of claim 5 wherein the gas inlet includes a porous medium having a pore rating of about 0.2 micrometers or less.
Claim 8
Dependent Claim
19 words
The system of claim 1 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 9
Dependent Claim
19 words
The system of claim 7 wherein the first porous medium has a CWST of greater than about 90 dynes/cm.
Claim 10
Dependent Claim
19 words
The system of claim 1 wherein the second porous medium has a CWST of greater than about 53 dynes/cm.
Claim 11
Dependent Claim
19 words
The system of claim 9 wherein the second porous medium has a CWST of greater than about 60 dynes/cm.
Claim 12
Dependent Claim
20 words
The system of claim 1 wherein the first porous medium and the second porous medium are both fibrous porous media.
Claim 13
Dependent Claim
34 words
The system of claim 1 wherein the first porous medium and the second porous medium are each capable of depleting the biological fluid of greater than 99.9% of the leukocytes in the biological fluid.
Claim 14
Dependent Claim
13 words
The system of claim 1 wherein the gas inlet includes a liquophobic membrane.
Claim 15
Dependent Claim
24 words
The system of claim 1 wherein at least one of the first porous medium and the second porous medium has a negative zeta potential.
Claim 16
Dependent Claim
43 words
The system of claim 1, further comprising a first gas outlet comprising a porous medium for passing gas therethrough, said gas outlet interposed between the first porous medium and the second container, or interposed between the second porous medium and the third container.
Claim 17
Dependent Claim
18 words
The system of claim 15, wherein the first gas outlet includes a liquophilic membrane and a liquophobic membrane.
Claim 18
Dependent Claim
130 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, a first gas outlet comprising a porous medium for passing gas therethrough, interposed between the first porous medium and the second container, or interposed between the second porous medium and the third container.
Claim 19
Dependent Claim
130 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, a first gas outlet comprising a porous medium for passing gas therethrough, interposed between the first porous medium and the second container, or interposed between the second porous medium and the third container.
Claim 20
Dependent Claim
50 words
The system of claim 17, further comprising a second gas outlet, said first gas outlet interposed between the first porous medium for passing biological fluid therethrough and the second container; and said second gas outlet interposed between the second porous medium for passing biological fluid therethrough and the third container.
Claim 21
Dependent Claim
10 words
The system of claim 18 comprising a closed sterile system.
Claim 22
Dependent Claim
17 words
The system of claim 17 further comprising an additional container in fluid communication with the second container.
Claim 23
Dependent Claim
28 words
The system of claim 17 wherein the gas outlet includes at least one porous medium that allows gas to pass therethrough but prevents the passage of bacteria therethrough.
Claim 24
Dependent Claim
23 words
The system of claim 21 wherein the gas outlet includes a porous medium having a pore rating of about 0.2 micrometers or less.
Claim 25
Dependent Claim
19 words
The system of claim 17 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 26
Dependent Claim
19 words
The system of claim 23 wherein the first porous medium has a CWST of greater than about 90 dynes/cm.
Claim 27
Dependent Claim
19 words
The system of claim 17 wherein the second porous medium has a CWST of greater than about 53 dynes/cm.
Claim 28
Dependent Claim
19 words
The system of claim 25 wherein the second porous medium has a CWST of greater than about 60 dynes/cm.
Claim 29
Dependent Claim
20 words
The system of claim 17 wherein the first porous medium and the second porous medium are both fibrous porous media.
Claim 30
Dependent Claim
34 words
The system of claim 17 wherein the first porous medium and the second porous medium are each capable of depleting the biological fluid of greater than 99.9% of the leukocytes in the biological fluid.
Claim 31
Dependent Claim
13 words
The system of claim 17 wherein the gas outlet includes a liquophobic membrane.
Claim 32
Dependent Claim
14 words
The system of claim 29 wherein the gas outlet further comprises a liquophilic membrane.
Claim 33
Dependent Claim
24 words
The system of claim 17 wherein at least one of the first porous medium and the second porous medium has a negative zeta potential.
Claim 34
Dependent Claim
134 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous fibrous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and a second porous fibrous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; the first porous fibrous medium and the second porous fibrous medium each having fibers which have an average fiber diameter of about 1 to about 4 micrometers; wherein the system comprises a closed sterile system.
Claim 35
Dependent Claim
134 words
A biological fluid processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous fibrous medium suitable for passing biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and a second porous fibrous medium suitable for passing biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; the first porous fibrous medium and the second porous fibrous medium each having fibers which have an average fiber diameter of about 1 to about 4 micrometers; wherein the system comprises a closed sterile system.
Claim 36
Dependent Claim
37 words
The system of claim 32 wherein the first porous fibrous medium and the second porous fibrous medium are each capable of depleting the biological fluid of greater than 99.9% of the leukocytes present in the biological fluid.
Claim 37
Dependent Claim
36 words
The system of claim 33 wherein the first porous fibrous medium has a CWST of greater than about 70 dynes/cm, and wherein the second porous fibrous medium has a CWST of greater than about 53 dynes/cm.
Claim 38
Dependent Claim
36 words
The system of claim 34 wherein the first porous fibrous medium has a CWST of greater than about 90 dynes/cm, and wherein the second fibrous porous medium has a CWST of greater than about 60 dynes/cm.
Claim 39
Dependent Claim
16 words
The system of claim 32 wherein the first and second porous fibrous media comprise synthetic fibers.
Claim 40
Dependent Claim
12 words
The system of claim 36 wherein the synthetic fibers comprise melt-blown fibers.
Claim 41
Independent Claim
98 words
A method for processing blood comprising: collecting human whole blood in a container; and, within about 8 hours of collecting the blood: centrifuging the whole blood to form a supernatant layer and a sediment layer; passing the supernatant layer of the centrifuged blood through a first porous medium, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and passing the sediment layer of the centrifuged blood through a second porous medium, the second porous medium comprising a leucocyte depletion medium.
Claim 42
Independent Claim
98 words
A method for processing blood comprising: collecting human whole blood in a container; and, within about 8 hours of collecting the blood: centrifuging the whole blood to form a supernatant layer and a sediment layer; passing the supernatant layer of the centrifuged blood through a first porous medium, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and passing the sediment layer of the centrifuged blood through a second porous medium, the second porous medium comprising a leucocyte depletion medium.
Claim 43
Dependent Claim
72 words
The method of claim 38 wherein centrifuging the whole blood includes separating the whole blood into a supernatant layer that includes platelets and a sediment layer that includes red blood cells; and, wherein passing the supernatant layer through the first porous medium comprises passing the centrifuged blood, supernatant layer first, through the red cell barrier medium or the combined leucocyte depletion red cell barrier medium until the first porous medium is blocked.
Claim 44
Dependent Claim
32 words
The method of claim 38 wherein passing the supernatant layer through the first porous medium depletes the supernatant layer of greater than about 99.9% of the leukocytes present in the supernatant layer.
Claim 45
Dependent Claim
32 words
The method of claim 40 wherein passing the sediment layer through the second porous medium depletes the sediment layer of greater than about 99.9% of the leukocytes present in the sediment layer.
Claim 46
Dependent Claim
32 words
The method of claim 38 wherein passing the sediment layer through the second porous medium depletes the sediment layer of greater than about 99.9% of the leukocytes present in the sediment layer.
Claim 47
Dependent Claim
18 words
The method of claim 38 wherein the method is carried out in a closed sterile blood processing system.
Claim 48
Dependent Claim
40 words
The method of claim 43 wherein passing supernatant layer through the first porous medium displaces gas, the method further comprising passing the displaced gas through a liquophobic membrane that allows the displaced gas, but not supernatant layer, to pass therethrough.
Claim 49
Dependent Claim
24 words
The method of claim 44 wherein passing gas through the liquophobic membrane includes separating gas from the blood processing system through a gas outlet.
Claim 50
Dependent Claim
40 words
The method of claim 43 wherein passing sediment layer through the second porous medium displaces gas, the method further comprising passing the displaced gas through a liquophobic membrane that allows the displaced gas, but not sediment layer, to pass therethrough.
Claim 51
Dependent Claim
24 words
The method of claim 46 wherein passing gas through the liquophobic membrane includes separating gas from the blood processing system through a gas outlet.
Claim 52
Dependent Claim
131 words
A biological fluid collection and processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing first biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing a second biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, at least one porous medium for passing gas therethrough, that allows gas to be separated from at least one of the first biological fluid and the second biological fluid.
Claim 53
Dependent Claim
131 words
A biological fluid collection and processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium suitable for passing first biological fluid therethrough interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; a second porous medium suitable for passing a second biological fluid therethrough interposed between the first container and the third container and comprising a leucocyte depletion medium; and, at least one porous medium for passing gas therethrough, that allows gas to be separated from at least one of the first biological fluid and the second biological fluid.
Claim 54
Dependent Claim
10 words
The system of claim 48 comprising a closed sterile system.
Claim 55
Dependent Claim
17 words
The system of claim 48 wherein the porous medium for passing gas therethrough comprises a liquophobic membrane.
Claim 56
Independent Claim
146 words
A method for processing biological fluid comprising: collecting biological fluid in a first container; forming a supernatant layer and a sediment layer of the biological fluid; passing the supernatant layer of the biological fluid from the first container through a first porous medium to a second container, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; passing the sediment layer of the biological fluid from the first container through a second porous medium to a third container, the second porous medium comprising a leucocyte depletion medium; the method further comprising passing gas through a gas inlet comprising a porous medium for passing gas therethrough, said gas inlet interposed between the first container and the first porous medium, or interposed between the first container and the second porous medium.
Claim 57
Independent Claim
146 words
A method for processing biological fluid comprising: collecting biological fluid in a first container; forming a supernatant layer and a sediment layer of the biological fluid; passing the supernatant layer of the biological fluid from the first container through a first porous medium to a second container, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; passing the sediment layer of the biological fluid from the first container through a second porous medium to a third container, the second porous medium comprising a leucocyte depletion medium; the method further comprising passing gas through a gas inlet comprising a porous medium for passing gas therethrough, said gas inlet interposed between the first container and the first porous medium, or interposed between the first container and the second porous medium.
Claim 58
Dependent Claim
43 words
The method of claim 51 wherein the gas inlet is interposed between the first container and the first porous medium, the method further comprising passing gas through the gas inlet, and collecting the supernatant layer displaced by the gas into the second container.
Claim 59
Dependent Claim
15 words
The method of claim 52 comprising collecting the supernatant layer in a closed sterile system.
Claim 60
Dependent Claim
53 words
The method of claim 52 wherein an additional gas inlet comprising a porous medium for passing gas therethrough is interposed between the first container and the second porous medium, the method further comprising passing gas through the additional gas inlet, and collecting the sediment layer displaced by the gas into the third container.
Claim 61
Dependent Claim
38 words
The method of claim 52 further comprising a gas outlet comprising a porous medium for passing gas therethrough interposed between the first porous medium and the second container, the method further comprising passing gas through the gas outlet.
Claim 62
Dependent Claim
43 words
The method of claim 51 wherein the gas inlet is interposed between the first container and the second porous medium, the method further comprising passing gas through the gas inlet, and collecting the sediment layer displaced by the gas into the third container.
Claim 63
Dependent Claim
15 words
The method of claim 56 comprising collecting the sediment layer in a closed sterile system.
Claim 64
Dependent Claim
38 words
The method of claim 56 further comprising a gas outlet comprising a porous medium for passing gas therethrough interposed between the second porous medium and the third container, the method further comprising passing gas through the gas outlet.
Claim 65
Independent Claim
146 words
A method for processing biological fluid comprising: collecting biological fluid in a first container; forming a supernatant layer and a sediment layer of the biological fluid; passing the supernatant layer of the biological fluid from the first container through a first porous medium to a second container, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; passing the sediment layer of the biological fluid from the first container through a second porous medium to a third container, the second porous medium comprising a leucocyte depletion medium; the method further comprising passing gas through a gas outlet comprising a porous medium for passing gas therethrough, said gas outlet interposed between the first porous medium and the second container, or interposed between the second porous medium and the third container.
Claim 66
Independent Claim
146 words
A method for processing biological fluid comprising: collecting biological fluid in a first container; forming a supernatant layer and a sediment layer of the biological fluid; passing the supernatant layer of the biological fluid from the first container through a first porous medium to a second container, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; passing the sediment layer of the biological fluid from the first container through a second porous medium to a third container, the second porous medium comprising a leucocyte depletion medium; the method further comprising passing gas through a gas outlet comprising a porous medium for passing gas therethrough, said gas outlet interposed between the first porous medium and the second container, or interposed between the second porous medium and the third container.
Claim 67
Dependent Claim
40 words
The method of claim 59 wherein the gas outlet is interposed between the first porous medium and the second container, the method further comprising passing gas through the gas outlet, and then collecting the supernatant layer in the second container.
Claim 68
Dependent Claim
15 words
The method of claim 60 comprising collecting the supernatant layer in a closed sterile system.
Claim 69
Dependent Claim
50 words
The method of claim 60 wherein an additional gas outlet comprising a porous medium for passing gas therethrough is interposed between the second porous medium and the third container, the method further comprising passing gas through the additional gas outlet, and then collecting the sediment layer in the third container.
Claim 70
Dependent Claim
40 words
The method of claim 59 wherein the gas outlet is interposed between the second porous medium and the third container, the method further comprising passing gas through the gas outlet, and then collecting the sediment layer in the third container.
Claim 71
Dependent Claim
15 words
The method of claim 63 comprising collecting the sediment layer in a closed sterile system.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-31 | 2000-09-30 | 2001-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-31 | 2004-09-30 | 2005-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-31 | 2008-09-30 | 2009-04-01 | $7700.00 | Window Closed / Lapsed |