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US5258126A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for obtaining platelets

Assignee: Pall Corp
•
Filing: 1992-03-05
•
Granted: 1993-11-02
•
Expires: 2012-03-05
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Abstract

Abstract A method is provided for processing donated blood, particularly a platelet-containing solution such as platelet-containing plasma, involving separating blood into a red cell containing sediment layer and a supernatant layer, and passing the supernatant layer through a filter until the filter is blocked, thereby leaving platelets to be harvested. The preferred filter comprises a porous medium having a plurality of zones of progressively increasing density.

Inventors

  • 👤 David B. Pall
  • 👤 Thomas C. Gsell

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 15:36
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/029; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B; B01; B01D; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; B01D61/00; B01D61/14; B01D61/147; B01D61/16; B01D63/00; B01D63/08; B01D63/087; A61J; A61J1/00; A61J1/05; A61J1/10; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 50 words
A method of harvesting platelets from a platelet-containing solution comprising: separating the platelet-containing solution into a supernatant layer and a sediment layer containing red cells; and passing the supernatant layer through a filter until red cells block the filter, said filter including a porous medium having zones of different density.
Claim 2
Independent Claim 50 words
A method of harvesting platelets from a platelet-containing solution comprising: separating the platelet-containing solution into a supernatant layer and a sediment layer containing red cells; and passing the supernatant layer through a filter until red cells block the filter, said filter including a porous medium having zones of different density.
Claim 3
Dependent Claim 22 words
The method of claim 1 wherein passing the supernatant layer through the porous medium comprises passing platelet-rich plasma through the porous medium.
Claim 4
Dependent Claim 20 words
The method of claim 1 wherein said filter comprises a porous medium having a CWST greater than about 70 dynes/cm.
Claim 5
Dependent Claim 37 words
The method of claim 2 wherein passing the supernatant layer through a filter further comprises passing the supernatant layer through a filter having a flow area of about 3 cm 2 to about 8 cm 2 .
Claim 6
Dependent Claim 54 words
The method of claim 1 wherein passing the supernatant layer through a filter further comprises passing the supernatant layer through a filter having a density range in an upstream portion from about 0.18 g/cc to about 0.23 g/cc, and a density range in the downstream portion from about 0.23 g/cc to about 0.40 g/cc.
Claim 7
Dependent Claim 32 words
The method of claim 5 wherein passing the supernatant layer through a porous medium having zones of different density comprises passing the supernatant layer through at least two zones of different density.
Claim 8
Dependent Claim 26 words
The method of claim 6 wherein passing the supernatant layer through zones of different density comprises passing the supernatant layer through zones of successively higher density.
Claim 9
Dependent Claim 72 words
The method of claim 7 wherein passing the supernatant layer through at least two zones of different density comprises passing the supernatant layer through an upstream zone including a density range from about 0.1 g/cc to about 0.2 g/cc, through an intermediate zone including a density range from about 0.20 g/cc to about 0.25 g/cc, and through a downstream zone including a density range from about 0.23 g/cc to about 0.40 g/cc.
Claim 10
Independent Claim 49 words
A method for treating blood comprising: centrifuging blood to create a supernatant layer and a sediment layer; and passing the supernatant layer of the centrifuged blood through a porous medium until red blood cells block the porous medium, said filter including a porous medium having zones of different density.
Claim 11
Independent Claim 49 words
A method for treating blood comprising: centrifuging blood to create a supernatant layer and a sediment layer; and passing the supernatant layer of the centrifuged blood through a porous medium until red blood cells block the porous medium, said filter including a porous medium having zones of different density.
Claim 12
Dependent Claim 16 words
The method of claim 9 further comprising collecting the supernatant layer passing through the porous medium.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1996-11-01 1997-05-03 1997-11-02 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2000-11-01 2001-05-03 2001-11-02 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2004-11-01 2005-05-03 2005-11-02 $7700.00 Window Closed / Lapsed

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