Compact plasma separator and an apparatus containing the same

Claim 2

A compact plasma separator comprising: a casing provided with blood introduction means for introducing blood to the casing, blood withdrawal means for withdrawing blood from the casing and at least one opening for plasma withdrawal; and a plurality of porous hollow fibers substantially equal in length, said fibers being arranged in a substantially parallel relationship and being bonded together at both end portions thereof to form a bundle, each porous hollow fiber of said bundle having openings at both ends thereof, said bundle being disposed in said casing along the length of said casing, said both end portions of the hollow fibers of said bundle being fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said blood introduction means and said blood withdrawal means thereby being in communication through said bundle of hollow fibers, said porous hollow fibers having an average effective length (L mm) not greater than 200 mm and a membrane surface area (S m 2 ) not greater than 0.3 m 2 , said average effective length (L mm) being defined as an average of the lengths of said porous hollow fibers minus the lengths of said both end portions of said porous hollow fibers at which the fibers are bonded together and fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said membrane surface area (S m 2 ) being defined by the formula: S=nπDL×10.sup.-6 wherein n is the number of porous hollow fibers, L is the average effective length and D is an average inner diameter (mm) of said porous hollow fibers, said average effective length (L mm) and said average inner diameter (D mm) satisfying the following relationship: L/D.sup.2 (mm.sup.-1)≧2000.

Claim 3

The plasma separator according to claim 1, wherein each porous hollow fiber comprises a membranous porous resin matrix having pores therewithin and openings on both surfaces thereof, said pores cooperating with said openings to form throughpaths running between both the surfaces of said resin matrix.

Claim 4

The plasma separator according to claim 1, wherein said porous hollow fibers have a porosity from 65 to 80%.

Claim 5

The plasma separator according to claim 1, wherein said porous hollow fibers have an average pore diameter from 0.1 to 0.5 μm.

Claim 6

The plasma separator according to claim 1, wherein said porous hollow fibers have a maximum pore diameter of 0.5 μm or less.

Claim 7

The plasma separator according to claim 1, wherein said average inner diameter is in the range from 100 to 316 μm.

Claim 8

The plasma separator according to claim 1, wherein said porous hollow fibers are produced by a thermoforming process.

Claim 9

The plasma separator according to claim 7, wherein said thermoforming process is a stretching perforation process.

Claim 10

A compact plasma separator apparatus comprising: (a) a compact plasma separator comprising: a casing provided with blood introduction means for introducing blood to the casing, blood withdrawal means for withdrawing blood from the casing and at least one opening for plasma withdrawal, and a plurality of porous hollow fibers substantially equal in length, said fibers being arranged in a substantially parallel relationship and being bonded together at both end portions thereof to form a bundle, each porous hollow fiber of said bundle having openings at both ends thereof, said bundle being disposed in said casing along the length of said casing, said both end portions of the hollow fibers of said bundle being fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said blood introduction means and said blood withdrawal means thereby being in communication through said bundle of hollow fibers, said porous hollow fibers having an average effective length (L mm) not greater than 200 mm and a membrane surface area (S m 2 ) not greater than 0.3 m 2 , said average effective length (L mm) being defined as an average of the lengths of said porous hollow fibers minus the lengths of said both end portions of said porous hollow fibers at which the fibers are bonded together and fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said membrane surface area (S m 2 ) being defined by the formula: S=nπDL×10.sup.-6 wherein n is the number of porous hollow fibers, L is the average effective length and D is an average inner diameter (mm) of said porous hollow fibers, said average effective length (L mm) and said average inner diameter (D mm) satisfying the following relationship: L/D.sup.2 (mm.sup.-1)≧2000; (b) blood introducing passage means for introducing blood to said blood introduction means, said blood introducing passage means comprising a first conduit having one end fluid-tightly connected to said blood introduction means of the plasma separator, a second conduit having a blood inlet at one end thereof, and means for transporting blood, said means for transporting blood being disposed between and fluid-tightly connected to the other ends of said first and second conduits; (c) blood withdrawing passage means for withdrawing blood from said blood withdrawal means, said blood withdrawing passage means comprising a third conduit having one end fluid-tightly connected to said blood withdrawal means of the plasma separator and having a blood outlet at the other end thereof; and (d) plasma withdrawing passage means for withdrawing plasma from said opening for plasma withdrawal, the plasma withdrawing passage means comprising a fourth conduit having one end fluid-tightly connected to said opening for plasma withdrawal of plasma separator and having a plasma outlet at the other end thereof.

Claim 11

A compact plasma separator apparatus comprising: (a) a compact plasma separator comprising: a casing provided with blood introduction means for introducing blood to the casing, blood withdrawal means for withdrawing blood from the casing and at least one opening for plasma withdrawal, and a plurality of porous hollow fibers substantially equal in length, said fibers being arranged in a substantially parallel relationship and being bonded together at both end portions thereof to form a bundle, each porous hollow fiber of said bundle having openings at both ends thereof, said bundle being disposed in said casing along the length of said casing, said both end portions of the hollow fibers of said bundle being fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said blood introduction means and said blood withdrawal means thereby being in communication through said bundle of hollow fibers, said porous hollow fibers having an average effective length (L mm) not greater than 200 mm and a membrane surface area (S m 2 ) not greater than 0.3 m 2 , said average effective length (L mm) being defined as an average of the lengths of said porous hollow fibers minus the lengths of said both end portions of said porous hollow fibers at which the fibers are bonded together and fluid-tightly connected to said blood introduction means and said blood withdrawal means, respectively, said membrane surface area (S m 2 ) being defined by the formula: S=nπDL×10.sup.-6 wherein n is the number of porous hollow fibers, L is the average effective length and D is an average inner diameter (mm) of said porous hollow fibers, said average effective length (L mm) and said average inner diameter (D mm) satisfying the following relationship: L/D.sup.2 (mm.sup.-1)≧2000; (b) blood introducing passage means for introducing blood to said blood introduction means, said blood introducing passage means comprising a first conduit having one end fluid-tightly connected to said blood introduction means of the plasma separator, a second conduit having a blood inlet at one end thereof, and means for transporting blood, said means for transporting blood being disposed between and fluid-tightly connected to the other ends of said first and second conduits; (c) blood withdrawing passage means for withdrawing blood from said blood withdrawal means, said blood withdrawing passage means comprising a third conduit having one end fluid-tightly connected to said blood withdrawal means of the plasma separator and having a blood outlet at the other end thereof; and (d) plasma withdrawing passage means for withdrawing plasma from said opening for plasma withdrawal, the plasma withdrawing passage means comprising a fourth conduit having one end fluid-tightly connected to said opening for plasma withdrawal of plasma separator and having a plasma outlet at the other end thereof.

Claim 12

The apparatus according to claim 9, wherein each porous hollow fiber comprises a membranous porous resin matrix having pores therein and openings on both surfaces thereof, said pores cooperating with said openings to form throughpaths running between both the surfaces of said resin matrix.