Patent US5516527A successfully refreshed from Google Patents.
US5516527A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dispensing device powered by hydrogel
Assignee: Pfizer Inc
•
Filing: 1992-10-09
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Granted: 1996-05-14
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Expires: 2012-10-09
Abstract
Abstract This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such hydrogel powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprises administering to or otherwise placing the devices of this invention in the environment of use.
Inventors
- 👤 William J. Curatolo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
139 words
A dispensing device for releasing a drug to an external environment which comprises: a capsule containing a plurality of dispensing devices, each dispensing device comprising (a) an innermost hydrogel layer, said innermost hydrogel layer not including drug; (b) a second layer, said second layer surrounding said innermost layer and said second layer comprising a mixture comprising one or more drugs and from about 50 to about 95 weight percent hydrogel, said hydrogel in said second layer being different from said hydrogel in said first layer; and (c) a porous coating which surrounds the mixture, said mixture in communication through said pores with the external environment, and said pores having a pore size sufficient to allow passage of the drugs through to the external environment wherein the rate of drug release is relatively independent of the solubility of the drug.
Claim 2
Dependent Claim
139 words
A dispensing device for releasing a drug to an external environment which comprises: a capsule containing a plurality of dispensing devices, each dispensing device comprising (a) an innermost hydrogel layer, said innermost hydrogel layer not including drug; (b) a second layer, said second layer surrounding said innermost layer and said second layer comprising a mixture comprising one or more drugs and from about 50 to about 95 weight percent hydrogel, said hydrogel in said second layer being different from said hydrogel in said first layer; and (c) a porous coating which surrounds the mixture, said mixture in communication through said pores with the external environment, and said pores having a pore size sufficient to allow passage of the drugs through to the external environment wherein the rate of drug release is relatively independent of the solubility of the drug.
Claim 3
Dependent Claim
16 words
The dispensing device according to claim 1 wherein the beneficial agent is a water insoluble drug.
Claim 4
Dependent Claim
13 words
The dispensing device according to claim 2 wherein the hydrogel is polyethylene oxide.
Claim 5
Dependent Claim
13 words
The dispensing device according to claim 3 wherein the coating comprises cellulose acetate.
Claim 6
Dependent Claim
16 words
The dispensing device according to claim 1 wherein the mixture additionally comprises an osmotically effective solute.
Claim 7
Dependent Claim
23 words
The dispensing device according to claim 2 wherein the pores have a diameter greater than the particle size of the water insoluble drug.
Claim 8
Dependent Claim
16 words
The dispensing device according to claim 4 wherein the coating additionally contains at least one hole.
Claim 9
Dependent Claim
30 words
A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the device of claim 1 into the environment of use.
Claim 10
Dependent Claim
30 words
The device as recited in claim 1 wherein the mixture comprises at least two drugs and the rate of drug release is relatively independent of the solubility of the drugs.
Claim 11
Dependent Claim
14 words
The device as recited in claim 1 wherein said device excludes a semi-permeable coating.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-14 | 1999-11-13 | 2000-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-14 | 2003-11-13 | 2004-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-14 | 2007-11-13 | 2008-05-14 | $7700.00 | Window Closed / Lapsed |