Delivery system housing a plurality of delivery devices

Claim 1

A delivery system for delivering a beneficial agent formulation, the delivery system comprising: (a) a wall that surrounds and forms an internal space, the wall comprising an inner lamina comprising a pH sensitive material that loses its physical and chemical integrity at a pH of 1.0 to 8.0 inclusive, and an outer lamina comprising a pH sensitive material that maintains its physical and chemical integrity at a pH of 1.0 and 3.5 inclusive, and loses its physical and chemical integrity at a pH of 3.5 to 8.0; (b) a plurality of tiny osmotic delivery devices useful for delivering a beneficial agent formulation and for co-delivering beneficial agent formulation combinations having a different biological half-life and therapeutic index in the space, the osmotic delivery devices comprising: (1) a semipermeable wall that surrounds and forms an internal compartment in the osmotic delivery device, the wall comprising a material that is permeable to the passage of an external fluid and substantially impermeable to the passage of a beneficial agent formulation; (2) a beneficial agent formulation in the compartment of each tiny osmotic delivery device that is soluble in fluid imbibed into the compartment and exhibits an osmotic pressure gradient across the semipermeable wall of the osmotic delivery device against an external fluid; and, (3) an osmotic passageway in the semipermeable wall of each tiny osmotic delivery device that communicates with the compartment containing the beneficial agent formulation and the exterior of the osmotic device for delivering the beneficial agent formulation through the passageway from the tiny osmotic device over time.