US5509932A
Expired / Lapsed
US
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Fixed tissue medical devices comprising albumin-binding dyes
Assignee: LATHAM DANIEL W
•
Filing: 1993-04-08
•
Granted: 1996-04-23
•
Expires: 2013-04-08
Abstract
Abstract An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.
Inventors
- 👤 James R. Keogh
- 👤 David A. Pearson
- 👤 John W. Eaton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61F; A61F2/00; A61F2/02; A61F2/24; A61L27/34; A61F2/2412
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
37 words
An implantable medical device comprising fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
Claim 2
Dependent Claim
37 words
An implantable medical device comprising fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when said device is in contact with a physiological fluid containing albumin.
Claim 3
Dependent Claim
15 words
The medical device of claim 1 wherein said albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 4
Dependent Claim
24 words
The medical device of claim 2 wherein said aromatic albumin-binding dye comprises a diazo dye, a sulfonic acid dye, or the physiologically-acceptable salts thereof.
Claim 5
Dependent Claim
52 words
The medical device of claim 3 wherein said aromatic albumin-binding dye is selected from the group consisting of 1-Amino-4((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3, 5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid, 6.6'-(3,3'-Diamethyl (1,1'-biphenyl)-4,4'diyl)bis(azo))bis(4-amino-5-hydroxy-1,3-naphthalene disulfonic acid) tetrasodium salt, 3,3'-(3,3'-Dimethyl(1,1'-biphenyl)-4,4'diyl)bis(-azo))bis(5-amino-4 hydroxy-2,7-naphthalenehydroxy disulfonic acid) tetrasodium salt, 4,4'-(3H-2,1-Benzoxathiol-3-ylidene) bis(2,6-dibromo-3-methylphenol)S,S-dioxide, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-6-methylphenol) S,S-dioxide, 4-(((4-dimethylamino) phenyl)azo)benzene-sulfonic acid sodium salt, 2-(4'-hydroxyazobenzene)benzoic acid, Procion red H-E 3B and mixtures thereof.
Claim 6
Dependent Claim
22 words
The medical device of claim 1 wherein said fixed tissue comprises a conjugate comprising said albumin-binding dye and a physiologically-acceptable water-soluble polysaccharide.
Claim 7
Dependent Claim
11 words
The medical device of claim 5 wherein said polysaccharide comprises dextran.
Claim 8
Dependent Claim
15 words
The medical device of claim 6 wherein said albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 9
Dependent Claim
25 words
The medical device of claim 7 wherein said aromatic albumin-binding dye comprises a diazo dye, a sulfonic acid dye, or the physiologically acceptable salts thereof.
Claim 10
Dependent Claim
50 words
The medical device of claim 8 wherein said aromatic albumin-binding dye is selected from the group consisting of 1-Amino-4((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid, 6,6'-(3,3'-Diamethyl (1,1'-biphenyl)-4,4'diyl)bis(azo))bis(4-amino-5-hydroxy-1,3-naphthalene disulfonic acid) tetrasodium salt, 3,3'-(3,3'-Dimethyl(1,1'-biphenyl)-4,4'diyl)bis(azo))bis(5-amino4 hydroxy-2,7-naphthalene disulfonic acid) tetrasodium salt, 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methylphenol)S,S-dioxide, 4,4'-(3H-2,1-benzoaxathiol-3-ylidene)bis(2-bromo-6-methylphenol) S,S-dioxide, 4-(((4-dimethylamino phenyl)azo)benzene-sulfonic acid sodium salt, 2-(4'-hydroxyazobenzene)benzoic acid, Procion red H-E 3B, and mixtures thereof.
Claim 11
Dependent Claim
17 words
The medical device of claim 1 wherein said fixed tissue comprises an animal tissue fixed with glutaraldehyde.
Claim 12
Dependent Claim
16 words
The medical device of claim 1 wherein said fixed tissue is treated with a reducing agent.
Claim 13
Dependent Claim
12 words
The medical device of claim 11 wherein said reducing agent is cyanoborohydride.
Claim 14
Dependent Claim
14 words
The medical device of claim 1 wherein the endogenous albumin is human serum albumin.
Claim 15
Dependent Claim
29 words
The medical device of claim 1 wherein said medical device is a replacement heart valve and wherein said fixed tissue is the fixed tissue of the replacement heart valve.
Claim 16
Dependent Claim
28 words
The medical device of claim 1 wherein said medical device is a replacement blood vessel and said fixed tissue is the fixed tissue of the replacement blood vessel.
Claim 17
Dependent Claim
52 words
An implantable medical device comprising: a surface of fixed tissue and on the fixed tissue surface an amount of a conjugate comprising: a. an albumin-binding dye and b. a physiologically-acceptable water-soluble polymer, wherein said amount of the conjugate is effective to bind albumin to the fixed tissue surface of said medical device.
Claim 18
Dependent Claim
52 words
An implantable medical device comprising: a surface of fixed tissue and on the fixed tissue surface an amount of a conjugate comprising: a. an albumin-binding dye and b. a physiologically-acceptable water-soluble polymer, wherein said amount of the conjugate is effective to bind albumin to the fixed tissue surface of said medical device.
Claim 19
Dependent Claim
14 words
The medical device of claim 16 wherein said physiologically-acceptable water-soluble polymer comprises a polysaccharide.
Claim 20
Dependent Claim
11 words
The medical device of claim 17 wherein said polysaccharide comprises dextran.
Claim 21
Dependent Claim
12 words
The medical device of claim 16 wherein said conjugate is a coating.
Claim 22
Dependent Claim
17 words
The medical device of claim 16 wherein said conjugate is cast or molded into the medical device.
Claim 23
Dependent Claim
29 words
The medical device of claim 16 wherein said medical device is a replacement heart valve and wherein said fixed tissue is the fixed tissue of the replacement heart valve.
Claim 24
Dependent Claim
28 words
The medical device of claim 16 wherein said medical device is a replacement blood vessel and said fixed tissue is the fixed tissue of the replacement blood vessel.
Claim 25
Dependent Claim
17 words
The medical device of claim 16 wherein said fixed tissue has been fixed by treatment with glutaraldehyde.
Claim 26
Dependent Claim
17 words
The medical device of claim 16 wherein said fixed tissue has been treated with a reducing agent.
Claim 27
Dependent Claim
12 words
The medical device of claim 24 wherein the reducing agent is cyanoborohydride.
Claim 28
Dependent Claim
15 words
The medical device of claim 16 wherein said albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 29
Dependent Claim
25 words
The medical device of claim 26 wherein said aromatic albumin-binding dye comprises a diazo dye, a sulfonic acid dye, or the physiologically acceptable salts thereof.
Claim 30
Dependent Claim
50 words
The medical device of claim 27 wherein said aromatic albumin-binding dye is selected from the group consisting of 1-Amino4((4-((4-chloro-6-((3(or 4)-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid, 6,6'-(3,3'-Diamethyl (1,1'-biphenyl)-4,4'diyl)bis(azo))bis(4-amino-5-hydroxy-1,3-naphthalene disulfonic acid) tetrasodium salt, 3,3'-(3,3'-Dimethyl(1,1'-biphenyl)-4,4'diyl)bis(azo))bis(5-amino-4 hydroxy-2,7-naphthalene disulfonic acid) tetrasodium salt, 4,4'-(3H-2,1-Benzoaxathiol-3-ylidene)bis(2,6-dibromo-3-methylphenol)S,S-dioxide, 4,4'-(3H-2,1-benzoaxathiol-3-ylidene)bis(2-bromo-6-methylphenol) S,S-dioxide, 4-(((4-dimethylamino) phenyl)azo)benzene-sulfonic acid sodium salt, 2-(4'-hydroxyazobenzene)benzoic acid, Procion red H-E 3B and mixtures thereof.
Claim 31
Independent Claim
68 words
A method of increasing the albumin-binding ability of a implantable medical device comprising fixed tissue, said method comprising the step of: a. incorporating into said fixed tissue an amount of an albumin-binding dye; wherein the amount of the albumin-binding dye is effective to form a coating of endogenous albumin on a surface of said fixed tissue when the surface is in contact with a physiological fluid containing albumin.
Claim 32
Independent Claim
68 words
A method of increasing the albumin-binding ability of a implantable medical device comprising fixed tissue, said method comprising the step of: a. incorporating into said fixed tissue an amount of an albumin-binding dye; wherein the amount of the albumin-binding dye is effective to form a coating of endogenous albumin on a surface of said fixed tissue when the surface is in contact with a physiological fluid containing albumin.
Claim 33
Dependent Claim
14 words
The method of claim 29 wherein the albumin-binding dye comprises an aromatic albumin-binding dye.
Claim 34
Dependent Claim
24 words
The method of claim 30 wherein the aromatic albumin-binding dye comprises a diazo dye, a sulfonic acid dye, or the physiologically acceptable salts thereof.
Claim 35
Dependent Claim
51 words
The method of claim 31 wherein the aromatic albumin-binding dye is selected from the group consisting of 1-Amino-4((4-((4-chloro-6-((3(or 4)-sulfophenyl) amino)-1,3,5-triazin-2-yl)amino)-3-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-2-anthracenesulfonic acid, 6,6'-(3,3'-Diamethyl (1,1'-biphenyl)-4,4'diyl)bis(azo))bis(4-amino-5-hydroxy-1,3-naphthalene disulfonic acid) tetrasodium salt, 3,3'-(3,3'-Dimethyl(1,1'-biphenyl)-4,4'diyl)bis(azo))bis(5-amino-4 hydroxy-2,7-naphthalene disulfonic acid) tetrasodium salt, 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2,6-dibromo-3-methylphenol)S,S-dioxide, 4,4'-(3H-2,1benzoxathiol-3-ylidene)bis(2-bromo-6-methylphenol) S,S-dioxide, 4-(((4-dimethylamino) phenyl)azo)benzene-sulfonic acid sodium salt, 2-(4'-hydroxyazobenzene) benzoic acid, Procion red H-E 3B, and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-23 | 1999-10-23 | 2000-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-23 | 2003-10-23 | 2004-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-23 | 2007-10-23 | 2008-04-23 | $7700.00 | Window Closed / Lapsed |