US5476516A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anticalcification treatment for aldehyde-tanned biological tissue
Assignee: Albert Einstein College of Medicine
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Filing: 1992-03-13
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Granted: 1995-12-19
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Expires: 2012-03-13
Abstract
Abstract A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having the formula: ##STR1## where R is CH 2 OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C 2 -C 9 or a carboxyalkyl; or ##STR2## where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.
Inventors
- 👤 Eli Seifter
- 👤 Robert W. M. Frater
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:56
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L27/3604; A61L27/3625; C; C14; C14C; C14C3/00; C14C3/02; C14C3/08; C14C3/16; A61L2400/00; A61L2400/02; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/901; Y10S623/915; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
61 words
A method of treating glutaraldehyde-tanned biological tissue for use in bioprosthetic valves and the like to minimize in vivo calcification and reduce cytotoxicity of the tanned tissue without impairing the mechanical strength of the tanned tissue, comprising the step of: treating the glutaraldehyde-tanned biological tissue with at least substantially solvent-free 1,2-propanediol to form a 5 member ring adduct of the glutaraldehyde.
Claim 2
Independent Claim
61 words
A method of treating glutaraldehyde-tanned biological tissue for use in bioprosthetic valves and the like to minimize in vivo calcification and reduce cytotoxicity of the tanned tissue without impairing the mechanical strength of the tanned tissue, comprising the step of: treating the glutaraldehyde-tanned biological tissue with at least substantially solvent-free 1,2-propanediol to form a 5 member ring adduct of the glutaraldehyde.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the 1,2-propanediol is a liquid at room temperature.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein said treating reduces cytotoxicity of the tanned tissue without impairing the mechanical strength of the tanned tissue.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the biological tissue is bovine pericardium.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the biological tissue is porcine aortic valve.
Claim 7
Dependent Claim
22 words
The method of claim 1 wherein the step comprises treating the glutaraldehyde-tanned biological tissue with a composition consisting essentially of said 1,2-propanediol.
Claim 8
Dependent Claim
30 words
The method of claim 1 wherein the step comprises treating the glutaraldehyde-tanned biological tissue with a composition consisting essentially of said 1,2-propanediol which is at least 60% by weight pure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-18 | 1999-06-19 | 1999-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-18 | 2003-06-19 | 2003-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-18 | 2007-06-19 | 2007-12-19 | $7700.00 | Window Closed / Lapsed |