US5407445A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gel composition for implant prosthesis and method of use
Assignee: LadRx Corp
•
Filing: 1993-05-19
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Granted: 1995-04-18
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Expires: 2013-05-19
Abstract
Abstract In accordance with the present invention, a composition and method is provided for a biocompatible filler for prostheses. The composition and method relate to certain polyoxyethylene/polyoxypropylene block copolymers which have gelling properties at body temperature and are ideally suited for use as fillers for a soft tissue prosthesis such as a breast implant.
Inventors
- 👤 Daiva K. Tautvydas
- 👤 Mannarsamy Balasubramanian
- 👤 R. Martin Emanuele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/18; A61L27/26; A61B; A61B17/00; A61B2017/00831; A61B2017/00902; A61F; A61F2/00; A61F2/02; A61F2/12; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
104 words
A method for providing a prosthesis approximating the consistency of human or animal tissue comprising the step of filling the lumen of the prosthesis with an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer.
Claim 2
Independent Claim
104 words
A method for providing a prosthesis approximating the consistency of human or animal tissue comprising the step of filling the lumen of the prosthesis with an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer.
Claim 3
Dependent Claim
28 words
The method of claim 1, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of between approximately 1750 and 4000 Daltons.
Claim 4
Dependent Claim
25 words
The method of claim 1, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of approximately 4000 Daltons.
Claim 5
Dependent Claim
93 words
A soft tissue prosthesis [with]comprising a lumen and a filler, wherein the filler comprises an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer.
Claim 6
Dependent Claim
93 words
A soft tissue prosthesis [with]comprising a lumen and a filler, wherein the filler comprises an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer.
Claim 7
Dependent Claim
28 words
The prosthesis of claim 4, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of between approximately 2750 and 4000 Daltons.
Claim 8
Dependent Claim
25 words
The prosthesis of claim 4, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of approximately 4000 Daltons.
Claim 9
Dependent Claim
12 words
The prosthesis of claim 4, wherein the prosthesis is a breast implant.
Claim 10
Independent Claim
117 words
A method of implanting a prosthesis into a human or animal comprising the steps of: implanting the lumen of the prosthesis into the body of the human or animal; filling the lumen with an aqueous solution of polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer; and, allowing the solution to gel.
Claim 11
Independent Claim
117 words
A method of implanting a prosthesis into a human or animal comprising the steps of: implanting the lumen of the prosthesis into the body of the human or animal; filling the lumen with an aqueous solution of polyoxyethylene-polyoxypropylene block copolymer having the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) b constitutes from about 50 to 90 percent by weight of the copolymer; and, allowing the solution to gel.
Claim 12
Dependent Claim
28 words
The method of claim 8, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of between approximately 2750 and 4000 Daltons.
Claim 13
Dependent Claim
25 words
The method of claim 8, wherein the hydrophobe represented by (C 3 H 6 O) a has an average molecular weight of approximately 4000 Daltons.
Claim 14
Dependent Claim
12 words
The method of claim 8, wherein the prosthesis is a breast implant.
Claim 15
Dependent Claim
16 words
The method of claim 8, wherein the gel further contains an effective amount of dermatan sulfate.
Claim 16
Dependent Claim
21 words
The method of claim 1, further comprising the step of adding a biologically compatible salt to the polyoxyethylene-polyoxypropylene block copolymer solution.
Claim 17
Dependent Claim
12 words
The method of claim 13 wherein the salt has a low radiodensity.
Claim 18
Dependent Claim
14 words
The soft tissue prosthesis of claim 4, wherein the filler further comprises a salt.
Claim 19
Dependent Claim
12 words
The soft tissue prosthesis of claim 4 wherein the filler is radiolucent.
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