US4820302A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bio compatible and blood compatible materials and methods
Assignee: WOODROOF LABORATORIES Inc A CORP OF
•
Filing: 1982-06-25
•
Granted: 1989-04-11
•
Expires: 2002-06-25
Abstract
Abstract Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.
Inventors
- 👤 E. Aubrey Woodroof
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:10
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L27/00; A61L27/14; A61L27/18
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
153 words
An implantable breast prosthesis comprising: a three dimensional member having an outer surface at least a portion of which is adapted to be in contact with tissue and the like in a host recipient, at least said portion of said member having functional groups extending therefrom, said functional group being selected from the group consisting of primary and secondary amino groups, said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and aryl-halide groups, a biological having functional groups selected from the group consisting of primary and secondary amino groups and hydroxyl groups being coupled to said portion of said member through reaction between the functional groups of said biological and the aldehyde or aryl-halide groups attached to said primary or secondary amino groups which extend from said portion of said member, and said biological operating to provide bio- and blood compatible qualities to said surface portion.
Claim 2
Dependent Claim
153 words
An implantable breast prosthesis comprising: a three dimensional member having an outer surface at least a portion of which is adapted to be in contact with tissue and the like in a host recipient, at least said portion of said member having functional groups extending therefrom, said functional group being selected from the group consisting of primary and secondary amino groups, said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and aryl-halide groups, a biological having functional groups selected from the group consisting of primary and secondary amino groups and hydroxyl groups being coupled to said portion of said member through reaction between the functional groups of said biological and the aldehyde or aryl-halide groups attached to said primary or secondary amino groups which extend from said portion of said member, and said biological operating to provide bio- and blood compatible qualities to said surface portion.
Claim 3
Dependent Claim
13 words
A prosthesis as set forth in claim 1 wherein said member is flexible.
Claim 4
Dependent Claim
15 words
A prosthesis as set forth in claim 2 wherein said member is flexible silicone rubber.
Claim 5
Dependent Claim
15 words
A prosthesis as set forth in claim 2 wherein said member encloses a malleable core.
Claim 6
Dependent Claim
26 words
A prosthesis as set forth in claim 2 wherein said member encloses a core of malleable material, said core of malleable material being a silicone gel.
Claim 7
Dependent Claim
18 words
A prosthesis as set forth in claim 2 wherein said biological is a collagen gelatin type A material.
Claim 8
Dependent Claim
13 words
A prosthesis as set forth in claim 2 wherein said biological is heparin.
Claim 9
Dependent Claim
25 words
A breast prosthesis as set forth in claim 2 wherein said member forms a body member, and said body member being a single lumen prosthesis.
Claim 10
Dependent Claim
25 words
A breast prosthesis as set forth in claim 2 wherein said member forms a body member, and said body member being a double lumen prosthesis.
Claim 11
Dependent Claim
35 words
A breast prosthesis as set forth in claim 2 wherein said biological is selected form the group consisting of; gelation Type A, high molecular weight gelatin Type A and low molecular weight gelatin Type A.
References Cited (Backward Citations)
US3617344A
Cited
US3457098A
Cited
US3639141A
Cited
US3846353A
Cited
DE2139455A1
Cited
US3955012A
Cited
US4001583A
Cited
US3986213A
Cited
US4060081A
Cited
US4243776A
Cited
US4329383A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-10 | 1992-10-10 | 1993-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-10 | 1996-10-10 | 1997-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-10 | 2000-10-10 | 2001-04-11 | $7700.00 | Window Closed / Lapsed |