US4828561A
Expired / Lapsed
US
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Bio compatible and blood compatible materials and methods
Assignee: Dow B Hickam Inc
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Filing: 1982-04-22
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Granted: 1989-05-09
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Expires: 2002-04-22
Abstract
Abstract Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.
Inventors
- 👤 E. Aubrey Woodroof
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:41
CPC Classifications
A; A61; A61K; A61K35/00; A61L; A61L27/00; A61L27/14; A61L27/18; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L27/22; A61L27/222; A61L33/00; A61L33/0005; A61L33/0011; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61F2310/00383; A61L2300/00; A61L2300/20; A61L2300/21; A61L2300/214; A61L2300/22; A61L2300/23; A61L2300/252; A61L2300/40; A61L2300/42; Y; Y10; Y10S; Y10S602/00; Y10S602/90
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
173 words
A method for imparting bio and blood compatible characteristics to a substrate wherein said substrate is a material which includes at least a surface portion which is a silicone polymer material, comprising the steps of: treating at least a portion of the surface of said substrate to provide functional reactive sites selected from the group consisting of primary and secondary amine functional sites coupled direclty to at least the silicone polymer material; activating said functional reactive sites with a material selected from the group consisting of an aryl halide and a dialdehyde to provide active connecting groups selected from the group consisting of aldehyde and halide connecting groups; and coupling to said connecting groups a biological having a functional group selected from the group consisting of hydroxyl, primary amine, and secondary amine functional groups, for reaction with said connecting groups to form a biological covalently bound to at least a portion of said substrate to impart thereto bio and blood compatible characeristics to at least a portion of the surface of said substrate.
Claim 2
Independent Claim
173 words
A method for imparting bio and blood compatible characteristics to a substrate wherein said substrate is a material which includes at least a surface portion which is a silicone polymer material, comprising the steps of: treating at least a portion of the surface of said substrate to provide functional reactive sites selected from the group consisting of primary and secondary amine functional sites coupled direclty to at least the silicone polymer material; activating said functional reactive sites with a material selected from the group consisting of an aryl halide and a dialdehyde to provide active connecting groups selected from the group consisting of aldehyde and halide connecting groups; and coupling to said connecting groups a biological having a functional group selected from the group consisting of hydroxyl, primary amine, and secondary amine functional groups, for reaction with said connecting groups to form a biological covalently bound to at least a portion of said substrate to impart thereto bio and blood compatible characeristics to at least a portion of the surface of said substrate.
Claim 3
Dependent Claim
48 words
A method as set forth in claim 1 wherein said substrate is a fabric-elastomer-matrix, said elastomer being a silicone rubber and said fabric being a nylon fabric joined to said silicone rubber, and said biological being coupled to the surface of said silicone rubber contacted by said fabric.
Claim 4
Dependent Claim
34 words
A method as set forth in claim 1 wherein said biiological is selected from the group consisting of: gelatin Type A, high molecular weight gelatin Type A, and low molecular weight gelatin Type A.
Claim 5
Dependent Claim
55 words
A method as set forth in claim 1 wherein said substrates is a nylon mesh fabric of 25 denier or less and having an elongation in each direction of at least 50%, and said silicone polymer material having a thickness of between 0.0006 and 0.020 inches and being at least as stretchable as said fabric.
Claim 6
Dependent Claim
25 words
A method as set forth in claim 1 wherein said biological is selected from the group consisting of proteins, carbohydrates, lipids, amino acids, and peptides.
Claim 7
Dependent Claim
31 words
A method as set forth in claim 1 wherein said substrate includes an outer exposed surface and wherein said entire outer exposed surface is treated to provide said functional reactive sites.
Claim 8
Dependent Claim
28 words
A method as set forth in claim 1 wherein said substrate is a three dimensional member having an outer surface on which said functional reactive sites are provided.
Claim 9
Dependent Claim
18 words
A method as set forth in claim 7 in which said three dimensional member encloses a malleable core.
Claim 10
Dependent Claim
29 words
A method as set forth in claim 1 wherein the step of treating to provide functional reactive sites includes the step of treating with an aminofunctional silane coupling agent.
Claim 11
Dependent Claim
43 words
A method as set forth in claim 1 wherein said treating step to provide functional reactive sites results in the provision of between 0.5×10 to the tenth power to 6.5×10 to the eleventh power binding cites per square centimeter of surface area treated.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-08 | 1992-11-07 | 1993-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-08 | 1996-11-07 | 1997-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-08 | 2000-11-07 | 2001-05-09 | $7700.00 | Window Closed / Lapsed |