Patent US5332802A successfully refreshed from Google Patents.
US5332802A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Human collagen processing and autoimplant use
Assignee: Collagenesis Inc
•
Filing: 1992-06-11
•
Granted: 1994-07-26
•
Expires: 2012-06-11
Abstract
Abstract Production of a chemically modified, crosslinkable, telopeptide-containing, naturally crosslinked, solubilized collagen from tissue obtained from a sole human donor, for implanting in the same donor, by chemically modifying the tissue, e.g. by acylation and/or esterification, to form an autoimplantable, crosslinkable, telopeptide-containing, naturally crosslinked, collagen product, as a completely solubilized collagen solution, optionally of high index of refraction for correcting sight or as a partially solubilized collagen suspension; and use of the product for altering the condition of in situ tissue of the same human donor by autoimplantation, such as by crosslinking the product to form an implant device, by placing an effective amount of the product at the tissue site and crosslinking the product in situ, or by partially crosslinking the product and placing an effective amount thereof at the tissue site and optionally further crosslinking the product in situ.
Inventors
- 👤 Charles D. Kelman
- 👤 Dale P. DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:16
CPC Classifications
C; C08; C08H; C08H1/00; C08H1/06; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K; A61K38/00; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
63 words
Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by reacting comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to at least partially solubilize said native telopeptide-containing collagen, wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
Claim 2
Dependent Claim
63 words
Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by reacting comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to at least partially solubilize said native telopeptide-containing collagen, wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
Claim 3
Dependent Claim
18 words
The composition according to claim 1, wherein said autoimplantable human collagen contains at least one acylated amine group.
Claim 4
Dependent Claim
32 words
The composition according to claim 2, wherein said at least one acylated amine group is selected from the group consisting of aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl and aromatic sulfonyl acyl moieties.
Claim 5
Dependent Claim
34 words
The composition according to claim 1, wherein said telopeptide-containing human collagen is chemically modified with a weight ratio of said amine reactive acylating agent to wet tissue of from about 0.005:1 to about 0.5:1.
Claim 6
Dependent Claim
19 words
The composition according to claim 1, wherein said autoimplantable human collagen composition contains at least one esterified carboxyl group.
Claim 7
Dependent Claim
26 words
The composition according to claim 5, wherein said at least one esterified carboxyl group is selected from the group consisting of aliphatic and aromatic ester moieties.
Claim 8
Dependent Claim
32 words
The composition according to claim 1, wherein said telopeptide-containing human collagen is chemically modified with a weight ratio of carboxylic acid esterifying agent to dry tissue of about 1:1 to about 30:1.
Claim 9
Dependent Claim
19 words
The composition of claim 1, wherein said composition has an index of refraction of about 1.500 to about 1.600.
Claim 10
Dependent Claim
16 words
An autoimplantable shaped article prepared by crosslinking in a predetermined shape the composition of claim 1.
Claim 11
Dependent Claim
61 words
Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by chemically modifying comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to solubilize said native telopeptide-containing collagen wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
Claim 12
Dependent Claim
61 words
Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by chemically modifying comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to solubilize said native telopeptide-containing collagen wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
Claim 13
Dependent Claim
18 words
The composition according to claim 10, wherein said autoimplantable human collagen contains at least one acylated amine group.
Claim 14
Dependent Claim
32 words
The composition according to claim 11, wherein said at least one acylated amine group is selected from the group consisting of aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl and aromatic sulfonyl acyl moieties.
Claim 15
Dependent Claim
34 words
The composition according to claim 10, wherein said telopeptide-containing human collagen is chemically modified with a weight ratio of said amine reactive acylating agent to wet tissue of from about 0.005:1 to about 0.5:1.
Claim 16
Dependent Claim
19 words
The composition according to claim 10, wherein said autoimplantable human collagen composition contains at least one esterified carboxyl group.
Claim 17
Dependent Claim
26 words
The composition according to claim 14, wherein said at least one esterified carboxyl group is selected from the group consisting of aliphatic and aromatic ester moieties.
Claim 18
Dependent Claim
32 words
The composition according to claim 10, wherein said telopeptide-containing human collagen is chemically modified with a weight ratio of carboxylic acid esterifying agent to dry tissue of about 1:1 to about 30:1.
Claim 19
Dependent Claim
19 words
The composition of claim 10, wherein said composition has an index of refraction of about 1.500 to about 1.600.
Claim 20
Dependent Claim
16 words
An autoimplantable shaped article prepared by crosslinking in a predetermined shape the composition of claim 10.
Claim 21
Dependent Claim
52 words
A composition for autoimplantation into a human comprising autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen derived from comminuted intact human tissue, said collagen having at least one selected from the group consisting of aliphatic amido group, aromatic amido group, aliphatic sulfonamido group, aromatic sulfonamido group, aliphatic ester group and aromatic ester group.
Claim 22
Dependent Claim
52 words
A composition for autoimplantation into a human comprising autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen derived from comminuted intact human tissue, said collagen having at least one selected from the group consisting of aliphatic amido group, aromatic amido group, aliphatic sulfonamido group, aromatic sulfonamido group, aliphatic ester group and aromatic ester group.
Claim 23
Dependent Claim
19 words
The composition of claim 19, wherein said composition has an index of refraction of about 1.500 to about 1.600.
Claim 24
Dependent Claim
16 words
An autoimplantable shaped article prepared by crosslinking in a predetermined shape the composition of claim 19.
References Cited (Backward Citations)
US3055790A
Cited
US3949703A
Cited
US3866809A
Cited
US3968567A
Cited
US4164559A
Cited
US4223984A
Cited
US4264155A
Cited
US4260228A
Cited
US4383832A
Cited
GB2086724A
Cited
US4381007A
Cited
US4511653A
Cited
US4582640A
Cited
US4581030A
Cited
US4505855A
Cited
US4695281A
Cited
US4563779A
Cited
US4544638A
Cited
US4553974A
Cited
US4557764A
Cited
EP0214853A2
Cited
US4713446A
Cited
US4676790A
Cited
US4983721A
Cited
EP1015284A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-07-25 | 1998-01-24 | 1998-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-07-25 | 2002-01-24 | 2002-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-07-25 | 2006-01-24 | 2006-07-26 | $7700.00 | Window Closed / Lapsed |