US5240862A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process and device for the separation of a body fluid from particulate materials
Assignee: Nanogen Inc
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Filing: 1989-03-23
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Granted: 1993-08-31
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Expires: 2009-03-23
Abstract
Abstract The present invention deals with a process and device for the separation of a body fluid from particulate materials in the fluid to be used for a chemical analysis of the fluid components. The process and device are in particular suitable for the separation of plasma from whole blood. Furthermore the present invention relates to a testing kit for the above mentioned separation and analysis purposes. The device has a collector membrane of defined capacity which intimately contacts the small pore side of a separator membrane having asymmetric pores passing through it permitting the application of a body fluid to the large pore side of the separator membrane.
Inventors
- 👤 Dirk M. Koenhen
- 👤 Johan J. Scharstuhl
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:04
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5023; G01N33/50; G01N33/52; G01N33/528; B01L2300/00; B01L2300/04; B01L2300/041; B01L2300/043; B01L2300/06; B01L2300/0681; B01L2300/08; B01L2300/0809; B01L2400/00; B01L2400/04; B01L2400/0403; B01L2400/0406; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
141 words
A process for the determination of constituents in body fluids which comprises applying a body fluid sample to a hydrophilic separator membrane having a plurality of asymmetric pores extending therethrough and having pore openings on first and second sides of said separator membrane which permit body fluids to pass through said pores while retaining particulate materials, said body fluid sample being applied to the first side of said asymmetric separator membrane in which the average size of the pore openings is larger than the average size of the pore openings on the second side of the separator membrane, collecting the separated body fluid passing through said separator membrane into a hydrophilic collector membrane having a defined pore volume so as to collect a determinable quantified amount of said body fluid, and analyzing for the constituents of said collected quantified body fluid.
Claim 2
Dependent Claim
141 words
A process for the determination of constituents in body fluids which comprises applying a body fluid sample to a hydrophilic separator membrane having a plurality of asymmetric pores extending therethrough and having pore openings on first and second sides of said separator membrane which permit body fluids to pass through said pores while retaining particulate materials, said body fluid sample being applied to the first side of said asymmetric separator membrane in which the average size of the pore openings is larger than the average size of the pore openings on the second side of the separator membrane, collecting the separated body fluid passing through said separator membrane into a hydrophilic collector membrane having a defined pore volume so as to collect a determinable quantified amount of said body fluid, and analyzing for the constituents of said collected quantified body fluid.
Claim 3
Dependent Claim
24 words
A process according to claim 1, wherein the collector membrane contains a reagent which is reactive with a component of the collected body fluid.
Claim 4
Dependent Claim
17 words
A process according to claim 1 wherein the separator membrane contains a coagulation or hemolysis inhibiting agent.
Claim 5
Dependent Claim
14 words
A process as defined in claim 1 wherein said body fluid is whole blood.
Claim 6
Dependent Claim
27 words
A process as defined in claim 1 wherein the separator and collector membranes are prepared by fixing a hydrophilic polymer in or on a hydrophobic polymer material.
Claim 7
Dependent Claim
59 words
A process as defined in claim 1 or claim 5 wherein the size of the pore openings on the first side of the separator membrane are in the range of 10 micrometers to 1 millimeter and the size of the pore openings on the second side of the separator membrane are in the range of 0.2 to 5 micrometers.
Claim 8
Dependent Claim
30 words
A process according to claim 5 wherein the hydrophobic polymer is selected from the group consisting of polysulphone, polyether sulphone and polyether imide and the hydrophilic polymer is polyvinyl pyrrolidone.
Claim 9
Independent Claim
114 words
A device for separating particulate materials from body fluids which comprises a holder containing a hydrophilic separator membrane having pores of asymmetric size extending therethrough and having pore openings on first and second sides of said separator membrane, a hydrophilic collector membrane having a determined capacity for collecting a quantified amount of body fluid, said collector membrane being in intimate surface contact with the second side of the separator membrane having pore openings of an average pore size smaller than the average pore size of the pores on the first side of the separator membrane, so that a quantified amount of body fluids passing through the separator membrane is collected by the collector membrane.
Claim 10
Independent Claim
114 words
A device for separating particulate materials from body fluids which comprises a holder containing a hydrophilic separator membrane having pores of asymmetric size extending therethrough and having pore openings on first and second sides of said separator membrane, a hydrophilic collector membrane having a determined capacity for collecting a quantified amount of body fluid, said collector membrane being in intimate surface contact with the second side of the separator membrane having pore openings of an average pore size smaller than the average pore size of the pores on the first side of the separator membrane, so that a quantified amount of body fluids passing through the separator membrane is collected by the collector membrane.
Claim 11
Dependent Claim
25 words
A device as defined in claim 8 wherein the collector membrane contains a reagent which is reactive with a component of the collected body fluid.
Claim 12
Dependent Claim
18 words
A device as defined in claim 8 wherein the separator membrane contains a coagulation or hemolysis inhibiting agent.
Claim 13
Dependent Claim
56 words
A device as defined in claim 8 wherein the size of the pore openings on the first side of the separator membrane are in the range of 10 micrometers to 1 millimeter and the size of the pore openings on the second side of the separator membrane are in the range of 0.2 to 5 micrometers.
Claim 14
Dependent Claim
25 words
A device as claimed in claim 8 or claim 11 including means for removing the collector membrane from intimate surface contact with the separator membrane.
Claim 15
Dependent Claim
27 words
A device as defined in claim 8 wherein the separator and collector membrane are prepared by fixing a hydrophilic polymer in or on a hydrophobic polymer material.
Claim 16
Dependent Claim
31 words
A device as defined in claim 13 wherein the hydrophobic polymer is selected from the group consisting of polysulphone, polyether polysulphone and polyether imide and the hydrophilic polymer is polyvinyl pyrrolidone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-30 | 1997-03-01 | 1997-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-30 | 2001-03-01 | 2001-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-30 | 2005-03-01 | 2005-08-31 | $7700.00 | Window Closed / Lapsed |