US4477575A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process and composition for separating plasma or serum from whole blood
Assignee: Roche Diagnostics GmbH
•
Filing: 1981-08-04
•
Granted: 1984-10-16
•
Expires: 2001-08-04
Abstract
Abstract A composition and process for permitting the separation of plasma or serum from whole blood. The composition includes glass fibers having an average diameter of from 0.2 mu to 5 mu and a density of 0.1 g/cm2 to 0.5 g/cm2. The process includes the steps of slowly trickling whole blood onto one side of a layer composed of the composition of glass fibers, whereby plasma or serum separated from the blood becomes available at another side of the layer. The total volume of the plasma or serum separated from the blood is limited to at most 50% of the absorption volume of the glass fiber layer.
Inventors
- 👤 Peter Vogel
- 👤 Hans-Peter Braun
- 👤 Dieter Berger
- 👤 Wolfgang Werner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:26
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B01; B01D; B01D39/00; B01D39/14; B01D39/20; B01D39/2003; B01D39/2017; G01N33/50; G01N33/52; G01N33/525; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
76 words
A process for separating plasma or serum from whole blood, comprising: trickling blood slowly onto a layer of glass fibers with an average diameter of 0.2 to 5μ and a density of 0.1 to 0.5 g./cm 3 , the total volume of the plasma or serum to be separated being at most 50% of the absorption volume of the glass fiber layer; and collecting the run-through from the glass fiber layer which is plasma or serum.
Claim 2
Dependent Claim
76 words
A process for separating plasma or serum from whole blood, comprising: trickling blood slowly onto a layer of glass fibers with an average diameter of 0.2 to 5μ and a density of 0.1 to 0.5 g./cm 3 , the total volume of the plasma or serum to be separated being at most 50% of the absorption volume of the glass fiber layer; and collecting the run-through from the glass fiber layer which is plasma or serum.
Claim 3
Dependent Claim
30 words
A process as claimed in claim 1, wherein the volume of plasma or serum to be separated is less than 30% of the absorption volume of the glass fiber layer.
Claim 4
Dependent Claim
20 words
A process as claimed in claim 2, wherein collecting the plasma comprises introducing the plasma directly into a diagnostic agent.
Claim 5
Dependent Claim
37 words
A process as claimed in claim 2, wherein collecting the plasma comprises taking it up in an absorbent carrier, and additionally comprising eluting the plasma into a diagnostic agent for the detection of the component materials thereof.
Claim 6
Dependent Claim
98 words
A process for separating plasma or serum from whole blood, comprising: providing a layer of glass fibers having an average diameter of from 0.2μ to 5μ and a density of from 0.1 g/cm 2 to 0.5 g/cm 2 ; slowly trickling whole blood onto one side of the layer of glass fibers, whereby plasma or serum separated from the blood becomes available at another side of the layer of glass fibers; and limiting the total volume of the plasma or serum separated from the blood to at most 50% of the absorption volume of the glass fiber layer.
Claim 7
Dependent Claim
98 words
A process for separating plasma or serum from whole blood, comprising: providing a layer of glass fibers having an average diameter of from 0.2μ to 5μ and a density of from 0.1 g/cm 2 to 0.5 g/cm 2 ; slowly trickling whole blood onto one side of the layer of glass fibers, whereby plasma or serum separated from the blood becomes available at another side of the layer of glass fibers; and limiting the total volume of the plasma or serum separated from the blood to at most 50% of the absorption volume of the glass fiber layer.
Claim 8
Dependent Claim
29 words
A process as in claim 5, wherein providing the layer of glass fibers comprises: providing a layer of glass fibers having an average diameter of from 0.5μ to 1.5μ.
Claim 9
Dependent Claim
38 words
A process as in claim 5, wherein providing the layer of glass fibers comprises: providing the layer of glass fibers mixed with synthetic resin fibers; and additionally comprising: consolidating the glass fiber layer with the synthetic resin fibers.
Claim 10
Dependent Claim
40 words
A process as in claim 5, wherein providing the layer of glass fibers comprises: providing the layer of glass fibers mixed with at least one binding agent; and additionally comprising: consolidating the layer of glass fibers with the binding agent.
Claim 11
Dependent Claim
63 words
A process as in claim 5, and additionally comprising: inserting the layer of glass fibers into a lower portion of a generally vertical hollow column before trickling the blood onto the layer of glass fibers, whereby the upper portion of the column is adapted to receive the blood and the lower portion of the column is adapted for discharging the plasma or serum.
Claim 12
Dependent Claim
62 words
A process as in claim 5, and additionally comprising: placing a diagnostic agent for detecting at least one component material of the plasma or serum in absorptive communication with the side of the layer of glass fibers from which the plasma or serum is available, whereby the plasma or serum is absorbed into the diagnostic agent for indicating the component material thereof.
Claim 13
Dependent Claim
38 words
A process as in claim 10, wherein the side of the layer of glass fibers in absorbant communication with the diagnostic agent comprises a portion of the side of the layer of glass fibers which receives the blood.
Claim 14
Dependent Claim
102 words
A process as in claim 10, wherein placing the diagnostic agent in absorptive communication with the layer of glass fibers comprises: providing a removable absorptive layer between the side of the glass fiber layer from which the plasma is available and the diagnostic agent; and arranging the removable absorptive layer for separation from the diagnostic agent after the plasma or seum has been absorbed thereby, whereby the layer of glass fibers is also removed from the diagnostic agent and the plasma- or serum-receiving surface of the diagnostic agent is exposed for its indication of the component material of the plasma or serum.
Claim 15
Dependent Claim
38 words
A process as in claim 12, and additionally comprising: providing a substrate or carrier; attaching another side of the diagnostic agent to the substrate; and attaching at least temporarily a portion of the removable layer to the substrate.
Claim 16
Dependent Claim
109 words
A process as in claim 5, and additionally comprising: providing a diagnostic agent capable of absorbing the plasma or serum from the side of the layer of glass fibers from which it is available for indicating at least one component material of the plasma or serum; and providing means for connecting the diagnostic agent with the layer of glass fibers in such normally spaced relation thereto that the diagnostic agent may be pressed into absorptive communication with the side of the layer of glass fibers from which the plasma or serum is available when it is desired to initiate the indication of the component material in the diagnostic agent.
Claim 17
Dependent Claim
99 words
A process as in claim 14, wherein the side of the layer of glass fibers from which the plasma or serum is available is a portion of the side of the layer of glass fibers which receives the blood; and additionally comprising providing a barrier extending across the side of the layer of glass fibers for separating the portion thereof, whereby blood placed on the one portion of the layer of glass fibers will not flow across the surface of the layer of glass fibers to the other portion which provides the plasma or serum to the diagnostic agent.
Claim 18
Dependent Claim
41 words
A process as in claim 15, wherein providing the barrier also comprises providing the means for supporting the diagnostic agent in normally spaced relation to the portion of the layer of glass fibers from which the plasma or serum is available.
References Cited (Backward Citations)
US3092465A
Cited
US3448041A
Cited
US3552925A
Cited
US3552928A
Cited
DE2150884A1
Cited
US3663374A
Cited
US3791933A
Cited
US3983005A
Cited
US4189382A
Cited
DE2545749A1
Cited
DE2453813A1
Cited
US4012325A
Cited
JPS5328495A
Cited
US4069017A
Cited
US4144306A
Cited
GB2018151A
Cited
US4246107A
Cited
US4223089A
Cited
US4256696A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-16 | 1988-04-16 | 1988-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-16 | 1992-04-16 | 1992-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-16 | 1996-04-16 | 1996-10-16 | $7700.00 | Window Closed / Lapsed |