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US4824639A
Expired / Lapsed
US
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Test device and a method for the detection of a component of a liquid sample
Assignee: Bayer AG
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Filing: 1988-02-03
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Granted: 1989-04-25
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Expires: 2008-02-03
Abstract
Abstract In a test strip for the detection of a component in a liquid sample, the strip comprising a support layer, a microporous polymer layer and a reagent for the detection of the component to be determined, the improvement wherein the microporous polymer layer is a membrane which has an asymmetric pore structure with the narrower pores being on the side to which the sample is applied, and the support layer is macroscopically smooth. The porous membrane is produced by coagulation from solution.
Inventors
- 👤 Karlheinz Hildenbrand
- 👤 Hans-Hagen von Dohren
- 👤 Hermann Perrey
- 👤 Georg Frank
- 👤 Rolf Dhein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:44
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/521; G01N33/523; Y; Y10; Y10S; Y10S435/00; Y10S435/805
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
137 words
A test device for the detection of a component in a liquid sample, the device comprising a support layer, a microporous polymer layer, one side of which facing the support, the other side of which being a side on which a sample can be applied and a reagent system for the detection of the component to be determined, the reagent system being incorporated in the polymer layer, the microporous polymer layer being a membrane which has an asymmetric pore structure with the pores narrowing toward the side to which the sample is applied, the microporous polymer layer being synthesized from a polymer selected from the group consisting of polyamides, polyether carbonates, polyacrylonitriles and polyurethanes and being produced by coagulation of a solution of the polymer, and the support layer being macroscopically smooth and impermeable to the sample.
Claim 2
Dependent Claim
137 words
A test device for the detection of a component in a liquid sample, the device comprising a support layer, a microporous polymer layer, one side of which facing the support, the other side of which being a side on which a sample can be applied and a reagent system for the detection of the component to be determined, the reagent system being incorporated in the polymer layer, the microporous polymer layer being a membrane which has an asymmetric pore structure with the pores narrowing toward the side to which the sample is applied, the microporous polymer layer being synthesized from a polymer selected from the group consisting of polyamides, polyether carbonates, polyacrylonitriles and polyurethanes and being produced by coagulation of a solution of the polymer, and the support layer being macroscopically smooth and impermeable to the sample.
Claim 3
Dependent Claim
32 words
A test device according to claim 1, wherein the ratio of the mean pore diameter on one surface of the membrane to that on the other membrane surface is greater than 10:1.
Claim 4
Dependent Claim
17 words
A test device according to claim 1, wherein the reagent layer is soluble or swellable in water.
Claim 5
Dependent Claim
31 words
A test device according to claim 1, wherein the ratio of mean pore diameter on one surface of the membrane to that on the other membrane surface is greater than 30:1.
Claim 6
Dependent Claim
17 words
A test device according to claim 1, wherein the support layer is a transparent polyethylene terephthalate film.
Claim 7
Dependent Claim
13 words
A test device according to claim 1, wherein the polyamides carry disulphide groups.
Claim 8
Dependent Claim
31 words
A test device according to claim 1, wherein the ratio of the mean pore diameter on the underside of the membrane to that on the membrane surface is greater than 5:1.
Claim 9
Dependent Claim
31 words
A test device according to claim 1, wherein the ratio of the mean pore diameter on the underside of the membrane to that on the membrane surface is greater than 30:1.
Claim 10
Dependent Claim
34 words
A test device according to claim 1 wherein the polymer further comprises a filler selected from the group consisting of SiO 2 , TiO 2 , BaSO 4 , ZnO, cellulose and agarose powder.
Claim 11
Dependent Claim
28 words
A test device according to claim 1, wherein the component to be determined is selected from the group consisting of glucose, bilirubin, urea, proteins, ketones, triglycerides and hemoglobin.
Claim 12
Dependent Claim
16 words
A test device according to claim 1, wherein the support layer is impermeable to the sample.
Claim 13
Dependent Claim
14 words
A test device according to claim 1, wherein the polymer comprises a polymer dispersion.
Claim 14
Dependent Claim
15 words
A test device according to claim 12, wherein the polymer dispersion further comprises ionic groups.
Claim 15
Dependent Claim
40 words
A test device according to claim 12, wherein the polymer dispersion is a dispersion of an ionic polyurethane bearing an anionic group selected from the group consisting of --SO 3 - , --COO - and --N + R 3 .
Claim 16
Dependent Claim
54 words
A method for detecting a component in a liquid sample comprising bringing said sample into contact with a test device according to claim 1, said sample being applied in such a manner so that the sample enters the membrane at a surface thereof having narrower pore diameters and detecting the presence of the sample.
Claim 17
Dependent Claim
24 words
A method according to claim 15, wherein the sample is applied to the membrane surface, and the detection is observed from the membrane surface.
Claim 18
Dependent Claim
27 words
A method according to claim 15, wherein a test device having a transparent support layer is used, and the detection is observed from underneath the support layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-24 | 1992-10-24 | 1993-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-24 | 1996-10-24 | 1997-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-24 | 2000-10-24 | 2001-04-25 | $7700.00 | Window Closed / Lapsed |