US5237993A
Expired / Lapsed
US
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Process and device for determining parameters of interest in living organisms
Assignee: SKRABAL FALCO
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Filing: 1991-11-19
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Granted: 1993-08-24
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Expires: 2011-11-19
Abstract
Abstract In order to determine at least one parameter of interest in a living organism, a perfusion is directly introduced in the tissues. After its partial balancing by the tissue parameter of interest, the perfusion fluid is collected and analyzed for the parameter of interest, as well as for endogenous or exogenous marker properties indicative of the degree of interaction between the perfusion fluid and the tissue, in such a way that the parameters of interest can be determined with the help of such characteristic properties. Contrary to usual processes, used exclusively inside blood vessels or other body cavities filled with liquid, this process creates in the tissues, i.e. in the closed cellular structure, a previously inexistent cavity, in which the perfusion fluid introduced in the tissue interacts directly with the organic tissue, with no intervening membranes. The transfer of the measurement site into the tissue completely eliminates the risk of the thromboses and embolies, besides strongly reducing the risk of infection.
Inventors
- 👤 Falko Skrabal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:13
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61B; A61B10/00; A61B10/0045; A61B5/00; A61B5/145; A61B5/14525; A61B5/14532; A61B5/14542; A61B5/1468; A61B5/1486; A61B5/14865; A61B5/15; A61B5/150007; A61B5/150015; A61B5/15003; A61B5/150206; A61B5/150244; A61B5/150251; A61B5/150374; A61B5/150381; A61B5/150389; A61B5/150396; A61B5/150503; A61B5/150511; A61B5/153; A61B5/155; A61B5/157; A61B5/48; A61B5/4836; A61B5/4839; A61M1/00; A61M1/71; A61M1/77; A61M1/84; A61M1/85; A61B10/007; A61M2230/00; A61M2230/20; A61M2230/201; A61M2230/65; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
219 words
A device for determining the concentration of at least one substance of interest in tissue of a living organism, comprising: (a) a subcutaneous needle/catheter insertable into the tissue of a living organism, said subcutaneous needle/catheter defining a tip and first and second passages, said first passage being configured as an exchange channel with first openings in wall areas for communication with said tissue and the second passage being configured as a drainage passage, said exchange channel being in communication with said drainage passage via at least one second opening near said tip of said subcutaneous needle/catheter; (b) a feeding/draining unit for feeding perfusion fluid into said exchange channel and draining said perfusion fluid from said drainage passage after said perfusion fluid has contacted said tissue via said first openings and become partially balanced by said at least one substance of interest in said tissue, (c) an analyzing unit connected to said drainage passage for analyzing said perfusion fluid for said at least one substance of interest, and including means for analyzing endogenous or exogenous marker properties indicative of the degree of interaction between said perfusion fluid and said tissue, and (d) an evaluation unit connected to said analyzing unit and including means for determining the concentration of said at least one substance of interest using said degree of interaction.
Claim 2
Independent Claim
219 words
A device for determining the concentration of at least one substance of interest in tissue of a living organism, comprising: (a) a subcutaneous needle/catheter insertable into the tissue of a living organism, said subcutaneous needle/catheter defining a tip and first and second passages, said first passage being configured as an exchange channel with first openings in wall areas for communication with said tissue and the second passage being configured as a drainage passage, said exchange channel being in communication with said drainage passage via at least one second opening near said tip of said subcutaneous needle/catheter; (b) a feeding/draining unit for feeding perfusion fluid into said exchange channel and draining said perfusion fluid from said drainage passage after said perfusion fluid has contacted said tissue via said first openings and become partially balanced by said at least one substance of interest in said tissue, (c) an analyzing unit connected to said drainage passage for analyzing said perfusion fluid for said at least one substance of interest, and including means for analyzing endogenous or exogenous marker properties indicative of the degree of interaction between said perfusion fluid and said tissue, and (d) an evaluation unit connected to said analyzing unit and including means for determining the concentration of said at least one substance of interest using said degree of interaction.
Claim 3
Dependent Claim
113 words
A device according to claim 1, wherein said feeding/drainage unit comprises a reservoir for said perfusion fluid, means forming a feeder passage which connects said reservoir with said exchange channel, a pump for circulation of perfusion fluid from said reservoir into said feeder passage, and a collecting vessel for perfusion fluid; wherein said analyzing unit includes sensors; and wherein said device includes a calibrating unit for calibrating said sensors in said analyzing unit, said calibrating unit comprising a container for calibrating solution, a valved connecting passage which connects said container with said analyzing unit, a pump for circulating said calibrating solution into said connecting passage, and a collecting vessel for said calibration solution.
Claim 4
Dependent Claim
46 words
A device according to claim 2, wherein said subcutaneous needle/catheter defines a base formed as a plug-in connection and wherein said feeder passage is contained in a plug which is insertable into said plug-in connection to provide communication between said feeder passage and said exchange channel.
Claim 5
Dependent Claim
57 words
A device according to claim 1, including a drug delivery unit which comprises a drug container, a drug feeding tube connecting said drug container with said subcutaneous needle/catheter and defining a drug discharge opening for discharging drug into said tissue, and a drug delivery pump for circulating drug from said drug container into said drug feeding tube.
Claim 6
Dependent Claim
57 words
A device according to claim 1, wherein said subcutaneous needle/catheter consists of first and second cannulas of respectively larger and smaller diameters, said second cannula being within said first cannula, said exchange channel being formed in an annular area between said first and second cannulas, said inner cannula not extending to said tip of said subcutaneous needle/catheter.
Claim 7
Dependent Claim
31 words
A device according to claim 1, wherein said subcutaneous needle/catheter includes a partition which extends along a length of said subcutaneous needle/catheter to provide said exchange channel and said drainage passage.
Claim 8
Dependent Claim
36 words
A device according to claim 1, wherein said subcutaneous needle/catheter defines a drug release opening near said top thereof and a third passage configured as a drug feeder tube which communicates with said drug release opening.
Claim 9
Dependent Claim
81 words
A device according to claim 1, wherein said subcutaneous needle/catheter consists of an outer cannula and an inner cannula, said exchange channel being formed between said inner cannula and said outer cannula, wherein said inner cannula includes a partition which defines said drainage passage and said drug feeding tube, wherein said first openings are in said outer cannula and said at least one second opening is in said inner cannula so as to communicate said exchange channel and said drainage passage.
Claim 10
Dependent Claim
57 words
A device according to claim 2, wherein a negative pressure sensor if provided in one of said drainage passage upstream of said analyzing unit, said drainage passage between said analyzing unit and said collecting vessel for perfusion fluid and said collecting vessel for said perfusion fluid, and wherein a temperature sensor is provided in said analyzing unit.
Claim 11
Dependent Claim
77 words
A device according to claim 1, including one of an ionic sensor and a conductivity meter in said analyzing unit for determining said marker variable and which acts as a negative pressure sensor, registering adequate filling of a measuring capillary in said analyzing unit, a signal of said evaluation unit effecting switchover or switch-off of a suction pump for said perfusion fluid, and wherein said device includes one of an acoustical alarm and an optical display means.
Claim 12
Dependent Claim
56 words
A device according to claim 1, wherein said analyzing unit for measuring said at least one substance to be analyzed and said endogenous or exogenous marker variables is configured as a replaceable unit, and including shutting means to close said passages connected to said analyzing unit upon disconnection of said replaceable unit from said subcutaneous needle/catheter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-23 | 1997-02-22 | 1997-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-23 | 2001-02-22 | 2001-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-23 | 2005-02-22 | 2005-08-24 | $7700.00 | Window Closed / Lapsed |