US5137875A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen
Assignee: Koken Co Ltd
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Filing: 1989-04-18
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Granted: 1992-08-11
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Expires: 2009-04-18
Abstract
Abstract A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH 2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.
Inventors
- 👤 Makoto Tsunenaga
- 👤 Naoki Tominaga
- 👤 Toshio Nishiyama
- 👤 Toru Yamashita
- 👤 Mutsumi Fukuyama
- 👤 Teruo Miyata
- 👤 Masayasu Furuse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:51
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/20; A61L27/22; A61L27/24; A61L27/50; C; C08; C08L; C08L5/00; C08L5/08; C08L89/00; C08L89/04; C08L89/06; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
70 words
An injectable aqueous dispersion for reparation of defective tissues in mammals having decreased absorption and increased volume retention, a pH of from about 6.5 to 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH 2 O and comprising 0.01 to 10 wt % of hyaluronic acid and 0.01 to 10 wt % of substantially non-porous collagen having a particle size of about 50 to about 100 microns.
Claim 2
Dependent Claim
70 words
An injectable aqueous dispersion for reparation of defective tissues in mammals having decreased absorption and increased volume retention, a pH of from about 6.5 to 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH 2 O and comprising 0.01 to 10 wt % of hyaluronic acid and 0.01 to 10 wt % of substantially non-porous collagen having a particle size of about 50 to about 100 microns.
Claim 3
Dependent Claim
21 words
The injectable aqueous dispersion of claim 1 wherein said collagen is selected from a group consisting of atelocollagen and regenerated atelocollagen.
Claim 4
Dependent Claim
21 words
A method of repairing voids in tissues of mammals comprising injecting the injectable aqueous dispersion of claim 1 into said voids.
Claim 5
Dependent Claim
34 words
An aqueous solution comprising a water-soluble collagen and hyaluronic acid and having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH 2 O.
Claim 6
Dependent Claim
34 words
An aqueous solution comprising a water-soluble collagen and hyaluronic acid and having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH 2 O.
Claim 7
Dependent Claim
12 words
An aqueous solution of claim 4, wherein water-soluble collagen is water-soluble atelocollagen.
Claim 8
Dependent Claim
15 words
The aqueous solution of claim 4, wherein the water-soluble collagen is derived from acid-soluble collagen.
Claim 9
Dependent Claim
28 words
The aqueous solution of claim 4, wherein hyaluronic acid content is from 0.01 to 10 wt % and water-soluble collagen content is from 0.01 to 10 wt %.
Claim 10
Dependent Claim
28 words
The aqueous dispersion of claim 5, wherein hyaluronic acid content is from 0.01 to 10 wt % and water-soluble collagen content is from 0.01 to 10 wt %.
Claim 11
Dependent Claim
21 words
A method of repairing voids in tissues of mammals comprising of injecting the aqueous solution of claim 4 into said voids.
Claim 12
Dependent Claim
55 words
An injectable aqueous solution comprising a water-soluble collagen and hyaluronic acid and having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/KgH 2 O for reparation of defective tissues in mammals having decreased absorption and increased volume retention and precipitating collagen fibers after injection.
Claim 13
Dependent Claim
55 words
An injectable aqueous solution comprising a water-soluble collagen and hyaluronic acid and having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/KgH 2 O for reparation of defective tissues in mammals having decreased absorption and increased volume retention and precipitating collagen fibers after injection.
Claim 14
Dependent Claim
29 words
The injectable aqueous solution of claim 10, wherein hyaluronic acid content is from 0.01 to 10 wt % and water-soluble collagen content is from 0.01 to 10 wt %.
Claim 15
Dependent Claim
24 words
The injectable aqueous solution of claim 11, wherein collagen fiber formulation rate is adjusted by changing respective concentrations of hyaluronic acid and water-soluble collagen.
Claim 16
Dependent Claim
29 words
The aqueous solution of claim 10, wherein said water-soluble collagen in said injectable aqueous solution remains water-soluble at low temperatures but precipitates at a body temperature of said mammals.
Claim 17
Dependent Claim
16 words
The injectable aqueous solution of claim 13, wherein said low temperatures are 10° C. or less.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-11 | 1996-02-10 | 1996-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-11 | 2000-02-10 | 2000-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-11 | 2004-02-10 | 2004-08-11 | $7700.00 | Window Closed / Lapsed |