US5100401A — Plastic composition with anti-hemolytic effect

Claim 1

Independent Claim 45 words

A flexible, plastic container having at least a portion of the interior surface thereof defined by a composition comprising a non-PVC copolymer and a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said container.

Claim 2

Dependent Claim 45 words

A flexible, plastic container having at least a portion of the interior surface thereof defined by a composition comprising a non-PVC copolymer and a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said container.

Claim 3

Dependent Claim 33 words

A plastic container in accordance with claim 1 wherein said citrate ester provides a controlled leaching of said citrate ester into the blood in order to suppress the hemolysis of red blood cells.

Claim 4

Dependent Claim 16 words

A plastic container in accordance with claim 1 wherein said non-PVC plastic is a polyolefin copolymer.

Claim 5

Dependent Claim 57 words

A plastic container in accordance with claim 3 wherein said polyolefin copolymer comprises: a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1) a central block, comprising 50% to 85% by weight of the copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units, and (2) terminal blocks of polystyrene.

Claim 6

Dependent Claim 29 words

A plastic container in accordance with claim 1 wherein said citrate ester is selected from the group consisting of acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/ octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate.

Claim 7

Dependent Claim 15 words

A plastic container in accordance with claim 1 wherein said citrate ester is n-butyryltri-n-hexyl citrate.

Claim 8

Dependent Claim 23 words

A plastic container in accordance with claim 3 wherein said composition further comprises a selected quantity of polyolefin consisting essentially of propylene units.

Claim 9

Dependent Claim 22 words

A plastic container in accordance with claim 7 wherein said composition comprises from 20% to 30% polyolefin consisting essentially of propylene units.

Claim 10

Dependent Claim 40 words

A plastic container in accordance with claim 7 wherein said composition comprises: 55% to 65% by weight of polyolefin copolymer 15% to 25% by weight of citrate ester; 20% to 30% by weight of polyolefin consisting of essentially propylene units.

Claim 11

Dependent Claim 70 words

A plastic container in accordance with claim 5 wherein said citrate ester has heat stability characteristics, after heating at 150° C. for two hours, of a color not greater than 50 to 60 apha, and a mild odor at 25° C. and has an aconitate level of less than about 0.2% when the esterification mixture from which said citrate is produced tests 0.5% maximum acidity when calculated as citric acid.

Claim 12

Dependent Claim 37 words

A plastic container in accordance with claim 5 wherein said citrate ester has a heat stability characteristic, after heating at 150° C. for two hours, of a neutralization number mg. KOH/g, of not greater than about 0.2.

Claim 13

Dependent Claim 44 words

A plastic container in accordance with claim 1 wherein said container comprises a plurality of layers and wherein an innermost layer is of a plastic composition comprising a non-PVC plastic and a citrate ester, and wherein the outer layer is of a different material.

Claim 14

Dependent Claim 15 words

A plastic container in accordance with claim 12 wherein said innermost layer is an emulsion.

Claim 15

Dependent Claim 26 words

A plastic container in accordance with claim 1 wherein said container includes means defining a container wall and said wall is made solely of said composition.

Claim 16

Dependent Claim 81 words

A multi-bag system comprising at least two flexible containers, conduit means providing sealed flow communication between said containers and conduit means for receiving red blood cells into at least one of said containers, wherein said one of said containers has at least a portion of the interior surface thereof formed of a plastic composition comprising a non-PVC plastic and a citrate-ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said one container.

Claim 17

Dependent Claim 81 words

A multi-bag system comprising at least two flexible containers, conduit means providing sealed flow communication between said containers and conduit means for receiving red blood cells into at least one of said containers, wherein said one of said containers has at least a portion of the interior surface thereof formed of a plastic composition comprising a non-PVC plastic and a citrate-ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said one container.

Claim 18

Dependent Claim 33 words

A multi-bag system in accordance with claim 15 wherein said citrate ester provides a controlled leaching of said citrate ester into the blood in order to suppress the hemolysis of red blood cells.

Claim 19

Dependent Claim 16 words

A multi-bag system in accordance with claim 15 wherein said non-PVC plastic is a polyolefin copolymer.

Claim 20

Dependent Claim 58 words

A multi-bag system in accordance with claim 10 wherein the said polyolefin copolymer comprises: a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1) a central block, comprising 50% to 85% by weight of the copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units, and (2) terminal blocks of polystyrene.

Claim 21

Dependent Claim 28 words

A multi-bag system as described in claim 15 wherein said citrate ester is selected from the group consisting of acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate and acetyltri-n-(octyl/decyl) citrate.

Claim 22

Dependent Claim 15 words

A multi-bag system in accordance with claim 15 wherein said citrate ester is n-butyryltri-n-hexyl citrate.

Claim 23

Dependent Claim 22 words

A multi-bag system in accordance with claim 15 wherein the quantity of citrate ester is from 15% to 25% of dry weight.

Claim 24

Dependent Claim 23 words

A multi-bag system in accordance with claim 17 wherein said composition further comprises a selected quantity of polyolefin consisting essentially of propylene units.

Claim 25

Dependent Claim 25 words

A multi-bag system in accordance with claim 22 wherein said composition comprises: 20% to 30% by weight of said polyolefin consisting essentially of propylene units.

Claim 26

Dependent Claim 45 words

A multi-bag system in accordance with claim 22 wherein at least one of said containers comprises: 55% to 65% by weight of said polyolefin copolymer; 15% to 25% by weight of citrate ester; 20% to 30% by weight of polyolefin consisting essentially of propylene units.

Claim 27

Independent Claim 74 words

A method of making a flexible, plastic container for storing red blood cells comprising: providing a non-PVC plastic; mixing with said non-PVC plastic a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said container; extruding the resultant material into a film of a selected thickness; forming said film into a selected container shape wherein said resultant material is co-extruded with a different material.

Claim 28

Independent Claim 74 words

A method of making a flexible, plastic container for storing red blood cells comprising: providing a non-PVC plastic; mixing with said non-PVC plastic a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis of red blood cells stored within said container; extruding the resultant material into a film of a selected thickness; forming said film into a selected container shape wherein said resultant material is co-extruded with a different material.

Claim 29

Dependent Claim 32 words

A method in accordance with claim 25 wherein said citrate ester provides a controlled leaching of said citrate ester into the blood in order to suppress the hemolysis of red blood cells.

Claim 30

Dependent Claim 15 words

A method in accordance with claim 25 wherein said non-PVC plastic is a polyolefin copolymer.

Claim 31

Dependent Claim 57 words

A method in accordance with claim 27 wherein the said polyolefin copolymer comprises: a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1) a central block, comprising 50% to 85% by weight of the copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units, and (2) terminal blocks of polystyrene.

Claim 32

Dependent Claim 29 words

A method as described in claim 25 wherein said material is a citrate ester selected from the group consisting of acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate and acetyltri-n-(octyl/decyl) citrate.

Claim 33

Dependent Claim 14 words

A method in accordance with claim 25 wherein said citrate ester is n-butyryltri-n-hexyl citrate.

Claim 34

Dependent Claim 21 words

A method in accordance with claim 25 wherein the quantity of citrate ester is from 15% to 25% of dry weight.

Claim 35

Dependent Claim 30 words

A method in accordance with claim 27 wherein said method further comprises the step of mixing with said polyolefin copolymer a selected quantity of polyolefin consisting essentially of propylene units.

Claim 36

Dependent Claim 24 words

A method in accordance with claim 32 wherein said resultant material comprises: 20% to 30% be weight of polyolefin consisting essentially of propylene units.

Claim 37

Dependent Claim 17 words

A method as described in claim 25 wherein said resultant material is co-extruded with a different material.

Claim 38

Dependent Claim 41 words

A method in accordance with claim 32 wherein said resultant material comprises: 55% to 65% by weight of said polyolefin copolymer; 15% to 25% by weight of citrate ester; 20% to 30% by weight of polyolefin consisting essentially of propylene units.

Claim 39

Dependent Claim 35 words

A method in accordance with claim 32 wherein said resultant material comprises: 55% by weight of said polyolefin copolymer; 15% by weight of n-butyryltri-n-hexyl citrate; 30% by weight of polyolefin consisting essentially of propylene units.

Claim 40

Independent Claim 82 words

A method for suppressing hemolysis of red blood cells comprising the steps of: providing a flexible, autoclavable, plastic container having at least a portion of the interior surface thereof formed of a composition comprising a non-PVC plastic and a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis in red blood cells; introducing a quantity of red blood cells into said container; maintaining said quantity of red blood cells within said container for a selected period of time.

Claim 41

Independent Claim 82 words

A method for suppressing hemolysis of red blood cells comprising the steps of: providing a flexible, autoclavable, plastic container having at least a portion of the interior surface thereof formed of a composition comprising a non-PVC plastic and a citrate ester, the quantity of said citrate ester being sufficient to suppress hemolysis in red blood cells; introducing a quantity of red blood cells into said container; maintaining said quantity of red blood cells within said container for a selected period of time.

Claim 42

Dependent Claim 32 words

A method in accordance with claim 37 wherein said citrate ester provides a controlled leaching of said citrate ester into the blood in order to suppress the hemolysis of red blood cells.

Claim 43

Dependent Claim 14 words

A method in accordance with claim 35 wherein non-PVC plastic is a polyolefin copolymer.

Claim 44

Dependent Claim 56 words

A method in accordance with claim 39 wherein said polyolefin copolymer comprises: a block copolymer, having thermoplastic rubber characteristics, consisting essentially of (1) a central block, comprising 50% to 85% by weight of the copolymer molecule, of a rubbery olefin polymer of generally equal proportions of ethylene and butylene units, and (2) terminal blocks of polystyrene.

Claim 45

Dependent Claim 27 words

A method in accordance with claim 37 wherein said citrate ester is selected from the group consisting of acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate and acetyltri-n-(octyl/decyl) citrate.

Claim 46

Dependent Claim 14 words

A method in accordance with claim 37 wherein said citrate ester is n-butyryltri-n-hexyl citrate.

Claim 47

Dependent Claim 16 words

A method in accordance with claim 37 wherein the composition comprises 15% to 25% citrate ester.

Claim 48

Dependent Claim 23 words

A method in accordance with claim 39 wherein said method further comprises the step of adding a polyolefin consisting essentially of propylene units.

Claim 49

Dependent Claim 24 words

A method in accordance with claim 44 wherein said composition comprises: 20% to 30% by weight of a polyolefin consisting essentially of propylene units.

Claim 50

Dependent Claim 39 words

A method in accordance with claim 44 wherein said composition comprises: 55% to 65% by weight of polyolefin copolymer; 15% to 25% by weight of citrate ester; 20% to 30% by weight of polyolefin consisting primarily of propylene units.

Claim 51

Dependent Claim 44 words

A method in accordance with claim 44 wherein at least a portion of the interior surface of said container comprises: 55% by weight of said polyolefin copolymer; 15% by weight of n-butyryltri-n-hexyl citrate; 30% by weight of said polyolefin consisting essentially of propylene units.

Claim 52

Dependent Claim 17 words

A method in accordance with claim 37 wherein said period of time is at least twenty-one days.

Claim 53

Dependent Claim 33 words

A plastic container in accordance with claim 20 comprising: 55% by weight of a polyolefin copolymer; 15% by weight of n-butyryltri-n-hexyl citrate ester; 30% by weight of polyolefin consisting essentially of propylene units.

Claim 54

Dependent Claim 35 words

A multi-bag system in accordance with claim 22 wherein said plastic composition comprises: 55% by weight of polyolefin copolymer; 15% by weight of n-butyryl-n-hexyl citrate; 30% by weight of polyolefin consisting essentially of propylene units.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-03-31	1995-09-30	1996-03-31	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-03-31	1999-09-30	2000-03-31	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-03-31	2003-09-30	2004-03-31	$7700.00	Window Closed / Lapsed

Plastic composition with anti-hemolytic effect

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