US4375509A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-hemolytic agent emulsions
Assignee: Baxter International Inc
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Filing: 1981-11-06
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Granted: 1983-03-01
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Expires: 2001-11-06
Abstract
Abstract Blood may be stored in vitro for a period of days at a reduced temperature in the container which also includes a sufficient quantity of an emulsion of anti-hemolytic agent to cause a reduction in the hemolysis of the stored blood, when compared with blood under similar storage conditions to the absence of the emulsion. Preferably, the emulsion may include a fatty ester containing at least two ester linkages each comprising a fatty hydrocarbon group, with the emulsion containing sufficient hemo-compatible surfactant to stabilize the emulsion.
Inventors
- 👤 Richard G. Buckles
- 👤 Jan W. Garber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:37
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
100 words
A blood storage container made of a hemocompatible material, said container also including sufficient quantity of a dispersed phosphate ester containing at least two ester linkages comprising fatty hydrocarbon groups, each of six to 12 carbon atoms, said ester linkages being bonded to the same phosphorous atom, said phosphate ester being present in sufficient amount to cause a reduction in the hemolysis of blood stored in said container for a period of 21 days, when compared with blood under similar storage conditions in the absence of said phosphate ester, said blood container also containing a blood nutrient and stabilizing agent.
Claim 2
Dependent Claim
100 words
A blood storage container made of a hemocompatible material, said container also including sufficient quantity of a dispersed phosphate ester containing at least two ester linkages comprising fatty hydrocarbon groups, each of six to 12 carbon atoms, said ester linkages being bonded to the same phosphorous atom, said phosphate ester being present in sufficient amount to cause a reduction in the hemolysis of blood stored in said container for a period of 21 days, when compared with blood under similar storage conditions in the absence of said phosphate ester, said blood container also containing a blood nutrient and stabilizing agent.
Claim 3
Dependent Claim
12 words
The container of claim 1 in which said phosphate ester is tri-2-ethylhexylphosphate.
Claim 4
Dependent Claim
21 words
The method of claim 1 in which said fatty hydrocarbon groups are selected from the group consisting of alkyl and alkenyl.
Claim 5
Dependent Claim
15 words
The blood storage container of claim 1 in which said fatty hydrocarbon groups are alkyl.
Claim 6
Dependent Claim
25 words
The blood storage container of claim 1 in which said dispersed phosphate ester is present in the container in the form of a stable emulsion.
Claim 7
Independent Claim
90 words
The method of storage of blood in vitro for a period of more than two days at a reduced temperature in a hemocompatible container which also contains sufficient quantity of a dispersed phosphate ester containing a plurality of ester linkages comprising fatty hydrocarbon groups of 4 to 12 carbon atoms each, said ester linkages being bonded to the same phosphorous atom, in sufficient concentration to cause a reduction in the hemolysis of the stored blood, when compared with blood under similar storage conditions in the absence of said phosphate ester.
Claim 8
Independent Claim
90 words
The method of storage of blood in vitro for a period of more than two days at a reduced temperature in a hemocompatible container which also contains sufficient quantity of a dispersed phosphate ester containing a plurality of ester linkages comprising fatty hydrocarbon groups of 4 to 12 carbon atoms each, said ester linkages being bonded to the same phosphorous atom, in sufficient concentration to cause a reduction in the hemolysis of the stored blood, when compared with blood under similar storage conditions in the absence of said phosphate ester.
Claim 9
Dependent Claim
12 words
The method of claim 6 in which said phosphate ester is tri-2-ethylhexylphosphate.
Claim 10
Dependent Claim
21 words
The method of claim 6 in which said fatty hydrocarbon groups are selected from the group consisting of alkyl and alkenyl.
Claim 11
Dependent Claim
23 words
The method of claim 6 in which said dispersed phosphate ester is present in the container in the form of a stable emulsion.
Claim 12
Dependent Claim
13 words
The method of claim 6 in which said fatty hydrocarbon groups are alkyl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-28 | 1986-08-30 | 1987-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-28 | 1990-08-30 | 1991-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-28 | 1994-08-30 | 1995-03-01 | $7700.00 | Window Closed / Lapsed |