US4451259A
Expired / Lapsed
US
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Blood storage method
Assignee: Baxter International Inc
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Filing: 1979-12-19
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Granted: 1984-05-29
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Expires: 1999-12-19
Abstract
Abstract Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable ester such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.
Inventors
- 👤 Ulrich C. Geissler
- 👤 Gerald A. Grode
- 👤 William J. Stith
- 👤 Ronald A. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:25
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/10; A61K; A61K35/00; A61K35/12; A61K35/14; A61L; A61L33/00; A61L33/0005; A61L33/0052; C; C08; C08K; C08K5/00; C08K5/04; C08K5/10; C08K5/12
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
112 words
The method which comprises storing blood for a period of days in a container made from a blood-compatible polymer, said polymer comprising a sterilizable, flexible, chlorine-free plastic material which contains sufficient antihemolytic agent dispersed therethrough to cause a reduced plasma hemoglobin content of the blood stored in contact therewith for 21 days, when compared with blood stored for a similar period of time in contact with the same blood-compatible material free of said antihemolytic agent, said antihemolytic agent comprising a fatty ester containing 2 ester linkages comprising fatty aliphatic hydrocarbon groups of 4 to 12 carbon atoms each, attached to a hydrocarbon chain and separated by no more than 7 carbon atoms.
Claim 2
Independent Claim
112 words
The method which comprises storing blood for a period of days in a container made from a blood-compatible polymer, said polymer comprising a sterilizable, flexible, chlorine-free plastic material which contains sufficient antihemolytic agent dispersed therethrough to cause a reduced plasma hemoglobin content of the blood stored in contact therewith for 21 days, when compared with blood stored for a similar period of time in contact with the same blood-compatible material free of said antihemolytic agent, said antihemolytic agent comprising a fatty ester containing 2 ester linkages comprising fatty aliphatic hydrocarbon groups of 4 to 12 carbon atoms each, attached to a hydrocarbon chain and separated by no more than 7 carbon atoms.
Claim 3
Dependent Claim
23 words
The method of claim 1 in which the ester linkages of said antihemolytic agent comprise alkyl groups of 7 to 10 carbon atoms.
Claim 4
Dependent Claim
24 words
The method of claim 2 in which said alkyl groups are branched alkyl groups, and said ester linkages are positioned on adjacent carbon atoms.
Claim 5
Dependent Claim
18 words
The method of claim 2 in which the ester groups of said antihemolytic agent contain branched octyl radicals.
Claim 6
Dependent Claim
12 words
The method of claim 4 in which said antihemolytic agent is di-2-ethylhexylphthalate.
Claim 7
Dependent Claim
12 words
The method of claim 4 in which said antihemolytic agent is diisononylphthalate.
Claim 8
Dependent Claim
12 words
The method of claim 4 in which said antihemolytic agent is diisodecylphthalate.
Claim 9
Dependent Claim
27 words
The method of claim 1 in which said container includes from 5 to 70 percent by weight of said antihemolytic agent, which also functions as a plasticizer.
Claim 10
Dependent Claim
21 words
The method of claim 8 in which said container contains from 15 to 40 percent by weight of said antihemolytic agent.
Claim 11
Independent Claim
86 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, flexible sterilizable, chlorine-free plastic material, while providing to said blood in said container a sufficient concentration of a dispersed dialkylphthalate in which said alkyl groups each contain 4 to 12 carbon atoms, to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent.
Claim 12
Independent Claim
86 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, flexible sterilizable, chlorine-free plastic material, while providing to said blood in said container a sufficient concentration of a dispersed dialkylphthalate in which said alkyl groups each contain 4 to 12 carbon atoms, to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent.
Claim 13
Independent Claim
71 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, flexible sterilizable, chlorine-free plastic material, while providing to said blood in the container a sufficient concentration of dispersed dioctylphthalate to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood-compatible material free of dioctylphthalate.
Claim 14
Independent Claim
71 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, flexible sterilizable, chlorine-free plastic material, while providing to said blood in the container a sufficient concentration of dispersed dioctylphthalate to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 days, when compared with blood stored in contact with the same blood-compatible material free of dioctylphthalate.
Claim 15
Dependent Claim
12 words
The method of claim 11 in which said dioctyl phthalate is di-2-ethylhexylphthalate.
Claim 16
Independent Claim
110 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, sterilizable, chlorine-free plastic material, while providing to said blood in said container a sufficient concentration of a dispersed antihemolytic agent to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 day, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent said antihemolytic agent comprising a fatty ester containing 2 ester linkages comprising fatty aliphatic hydrocarbon groups of 4 to 12 carbon atoms each on a hydrocarbon chain and separated by no more than 7 carbon atoms.
Claim 17
Independent Claim
110 words
The method of storing blood for over a day into a container made of a blood-compatible polymer which comprises a hemocompatible, sterilizable, chlorine-free plastic material, while providing to said blood in said container a sufficient concentration of a dispersed antihemolytic agent to cause a reduced plasma hemoglobin content of blood stored in contact therewith for 21 day, when compared with blood stored in contact with the same blood-compatible material free of said antihemolytic agent said antihemolytic agent comprising a fatty ester containing 2 ester linkages comprising fatty aliphatic hydrocarbon groups of 4 to 12 carbon atoms each on a hydrocarbon chain and separated by no more than 7 carbon atoms.
Claim 18
Dependent Claim
20 words
The method of claim 13 in which said ester linkages are spaced on adjacent carbon atoms of said hydrocarbon chain.
Claim 19
Dependent Claim
23 words
The method of claim 14 in which the ester linkages of said antihemolytic agent comprise alkyl groups of 7 to 10 carbon atoms.
Claim 20
Dependent Claim
14 words
The method of claim 15 in which said alkyl groups are branched alkyl groups.
Claim 21
Dependent Claim
18 words
The method of claim 15 in which the ester groups of said antihemolytic agent contain branched octyl radicals.
Claim 22
Dependent Claim
15 words
The method of claim 13 in which said hydrocarbon chain is linear and highly mobile.
References Cited (Backward Citations)
US2980964A
Cited
US3308086A
Cited
US3645955A
Cited
US4076678A
Cited
US4085083A
Cited
US3749134A
Cited
US4046725A
Cited
US4286597A
Cited
US4300559A
Cited
US4301800A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |