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US5073373A
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Flowable demineralized bone powder composition and its use in bone repair
Assignee: Osteotech Investment Corp
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Filing: 1989-09-21
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Granted: 1991-12-17
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Expires: 2009-09-21
Abstract
Abstract A flowable demineralized bone powder composition is provided for use in surgical bone repair.
Inventors
- 👤 Robert K. O'Leary
- 👤 Patrick A. McBrayer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61K; A61K35/00; A61K35/12; A61K35/32; A61L24/00; A61L24/0005; A61L27/14; A61L27/22; A61L27/227; A61L27/3641; A61L27/3645; A61L27/365; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2835; A61L2400/00; A61L2400/06; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A flowable composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth-inducing amount of pulverized demineralized osteogenic bone powder in a biocompatible carrier for the bone powder wherein said carrier is selected from the group consisting of glycerol, monoacetin, diacetin and mixtures thereof.
Claim 2
Dependent Claim
55 words
A flowable composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth-inducing amount of pulverized demineralized osteogenic bone powder in a biocompatible carrier for the bone powder wherein said carrier is selected from the group consisting of glycerol, monoacetin, diacetin and mixtures thereof.
Claim 3
Dependent Claim
23 words
The composition of claim 1 wherein the average particle size of the demineralized bone powder is from about 0.1 to about 1.2 cm.
Claim 4
Dependent Claim
10 words
The composition of claim 1 wherein the carrier is glycerol.
Claim 5
Dependent Claim
72 words
The composition of claim 3 containing at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, protein synthesis co-factor hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, polymeric drug carrier, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal agent, bone digester, antitumor agent, cellular attractant, cellular attachment agent, immunosuppressant, nucleic acid, surface active agent and penetration enhancer.
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein the average particle size of the demineralized bone powder is from about 0.2 to about 1 cm.
Claim 7
Dependent Claim
21 words
The composition of claim 1 wherein the demineralized bone powder is derived from cortical bone, cancellous and/or corticocancellous allogenic bone tissue.
Claim 8
Dependent Claim
17 words
The composition of claim 1 containing from about 5 to about 80 weight percent demineralized bone powder.
Claim 9
Dependent Claim
17 words
The composition of claim 1 containing from about 20 to about 60 weight percent demineralized bone powder.
Claim 10
Dependent Claim
72 words
The composition of claim 1 containing at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, protein synthesis co-factor, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, polymeric drug carrier, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal agent, bone digester, antitumor agent, cellular attractant, cellular attachment agent, immunosuppressant, nucleic acid, surface active agent and penetration enhancer.
Claim 11
Dependent Claim
23 words
The composition of claim 3 wherein the average particle size of the demineralized bone powder is from about 0.1 to about 1.2 cm.
Claim 12
Dependent Claim
23 words
The composition of claim 3 wherein the average particle size of the demineralized bone powder is from about 0.2 to about 1 cm.
Claim 13
Dependent Claim
20 words
The composition of claim 3 wherein the demineralized bone powder is derived from cortical cancellous and/or corticocancellous allogenic bone tissue.
Claim 14
Dependent Claim
17 words
The composition of claim 3 containing from about 5 to about 80 weight percent demineralized bone powder.
Claim 15
Dependent Claim
17 words
The composition of claim 3 containing from about 20 to about 60 weight percent demineralized bone powder.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-16 | 1995-06-17 | 1995-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-16 | 1999-06-17 | 1999-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-16 | 2003-06-17 | 2003-12-17 | $7700.00 | Window Closed / Lapsed |