Patent US5019087A successfully refreshed from Google Patents.
US5019087A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nerve regeneration conduit
Assignee: COLLA-TEC Inc A CORP OF DE
•
Filing: 1986-10-06
•
Granted: 1991-05-28
•
Expires: 2006-10-06
Abstract
Abstract The present invention is directed to a hollow conduit comprised of a matrix of Type I collagen and laminin-containing material which conduit is used to promote nerve regeneration across a gap of a severed nerve. Methods of making the nerve regeneration conduit are also disclosed.
Inventors
- 👤 Joseph Nichols
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:21
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61B; A61B17/00; A61B17/11; A61B17/1128; A61L31/005; A61L31/047; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2230/00; A61F2230/0063; A61F2230/0069; A61L2430/00; A61L2430/32
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
37 words
A hollow conduit for promoting the in vivo regeneration of a severed mammalian nerve so as to bridge a gap between its severed ends having walls comprised of a matrix of Type I collagen and laminin-containing material.
Claim 2
Dependent Claim
37 words
A hollow conduit for promoting the in vivo regeneration of a severed mammalian nerve so as to bridge a gap between its severed ends having walls comprised of a matrix of Type I collagen and laminin-containing material.
Claim 3
Dependent Claim
16 words
The hollow conduit of claim 1, wherein the Type I collagen is derived from bovine tendons.
Claim 4
Dependent Claim
15 words
The hollow conduit of claim 1, wherein the laminin-containing material is purified human placenta laminin.
Claim 5
Dependent Claim
15 words
The hollow conduit of claim 1, wherein the laminin-containing material is derived from basement membrane.
Claim 6
Dependent Claim
17 words
The hollow conduit of claim 1 having an inner diameter of about 1 mm to 1 cm.
Claim 7
Dependent Claim
16 words
The hollow conduit of claim 1 having a wall thickness of about 0.05 to 0.2 mm.
Claim 8
Dependent Claim
29 words
The hollow conduit of claim 1 wherein the amount of Type I collagen present to the amount of laminin-containing material is in the ratio of about 90:10 to 40:60.
Claim 9
Dependent Claim
35 words
The hollow conduit of claim 1 wherein the walls further contain any of the group consisting of glycoproteins, proteoglycans, heparan sulfate proteoglycan, nidogen, glycosaminoglycans, fibronectin, epidermal growth factor or nerve growth factors, or combinations thereof.
Claim 10
Independent Claim
54 words
A method of promoting in vivo regeneration of a mammalian severed nerve so as to bridge a gap between its severed ends comprising bringing the respective ends of the severed nerve into contact with each end of a hollow conduit whose walls are comprised of a matrix of Type I collagen and laminin-containing material.
Claim 11
Independent Claim
54 words
A method of promoting in vivo regeneration of a mammalian severed nerve so as to bridge a gap between its severed ends comprising bringing the respective ends of the severed nerve into contact with each end of a hollow conduit whose walls are comprised of a matrix of Type I collagen and laminin-containing material.
Claim 12
Dependent Claim
21 words
The method of claim 9, wherein the ends of the severed nerve are sutured to each respective end of the conduit.
References Cited (Backward Citations)
US3551560A
Cited
US3833002A
Cited
US4325867A
Cited
US4376071A
Cited
US4451397A
Cited
US4544552A
Cited
US4621631A
Cited
US4642120A
Cited
US4642293A
Cited
US4448718A
Cited
US4662884A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-27 | 1994-11-26 | 1995-05-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-27 | 1998-11-26 | 1999-05-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-27 | 2002-11-26 | 2003-05-28 | $7700.00 | Window Closed / Lapsed |