Patent US5846261A successfully refreshed from Google Patents.
US4451397A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing collagen products
Assignee: Centre Technique Cuir Chaussure Maroquinerie
•
Filing: 1982-11-22
•
Granted: 1984-05-29
•
Expires: 2002-11-22
Abstract
Abstract New and highly stable preparations containing collagen in association with mucopolysaccharides are obtained by combining a homogeneous gel or solution of crosslinked or decrosslinked collagen, and a solution of CSA or CSC, and bringing the pH to 7.
Inventors
- 👤 Alain R. Huc
- 👤 Roland L. Allard
- 👤 Christian L. Chavrier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:20
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/65; A61K8/72; A61K8/73; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
110 words
A method of preparing a collagen mucopolysaccharide composition in the form of a clear solution which comprises the steps of: (a) contacting ground collagenous material with an alkali solution having a pH of 14 for a prolonged time period to form a collagenous mixture; (b) acidifying the collagenous mixture formed during step (a) to a pH of 2 to form decrosslinked collagen in the form of a solution or gel; and (c) combining the decrosslinked collagen in the form of a solution or gel with a solution of a glycosaminoglycan, and then bringing the pH of the combined solutions to 7 by addition of alkali, thereby producing the desired product.
Claim 2
Independent Claim
110 words
A method of preparing a collagen mucopolysaccharide composition in the form of a clear solution which comprises the steps of: (a) contacting ground collagenous material with an alkali solution having a pH of 14 for a prolonged time period to form a collagenous mixture; (b) acidifying the collagenous mixture formed during step (a) to a pH of 2 to form decrosslinked collagen in the form of a solution or gel; and (c) combining the decrosslinked collagen in the form of a solution or gel with a solution of a glycosaminoglycan, and then bringing the pH of the combined solutions to 7 by addition of alkali, thereby producing the desired product.
Claim 3
Dependent Claim
21 words
The method defined in claim 1, step (c), wherein the concentration of collagen is about twice the concentration of the glycosaminoglycan.
Claim 4
Independent Claim
75 words
A method of preparing a collagen mucopolysaccharide composition in the form of a homogeneous gel which comprises the steps of: (a) obtaining crosslinked natural collagen in the form of a gel from dehydrated collagen fibers; and (b) combining the crosslinked natural collagen in the form of a gel with a solution of a glycosaminoglycan, and then bringing the pH of the combined solutions to 7 by the addition of alkali, thereby producing the desired product.
Claim 5
Independent Claim
75 words
A method of preparing a collagen mucopolysaccharide composition in the form of a homogeneous gel which comprises the steps of: (a) obtaining crosslinked natural collagen in the form of a gel from dehydrated collagen fibers; and (b) combining the crosslinked natural collagen in the form of a gel with a solution of a glycosaminoglycan, and then bringing the pH of the combined solutions to 7 by the addition of alkali, thereby producing the desired product.
Claim 6
Dependent Claim
21 words
The method defined in claim 3, step (b), wherein the concentration of collagen is about twice the concentration of the glycosaminoglycan.
Claim 7
Dependent Claim
39 words
The method defined in claim 3, further comprising the step of: (c) lyophilizing the collagen mucopolysaccharide composition in the form of a gel to form a layer having a thickness of 10 mm or less, thereby forming a sponge.
Claim 8
Dependent Claim
28 words
A method of promoting the growth of bone which comprises the step of applying to a site where osteocytes are active a sponge formed according to claim 5.
References Cited (Backward Citations)
US3527225A
Cited
GB1190879A
Cited
FR2332863A1
Cited
US4060081A
Cited
US4280954A
Cited
US4140537A
Cited
FR2362632A1
Cited
US4378017A
Cited
US4294753A
Cited
US4350629A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |