US5017370A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Improved method of performing angioplasty procedures
Assignee: Emory University
•
Filing: 1990-05-03
•
Granted: 1991-05-21
•
Expires: 2010-05-03
Abstract
Abstract In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing certain ethylene oxide-propylene oxide condensation surface-active copolymers before, during and/or after the angioplasty procedure. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the copolymer.
Inventors
- 👤 Robert L. Hunter
- 👤 Alexander Duncan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
106 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 2
Independent Claim
106 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 3
Dependent Claim
75 words
The method of claim 1 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 4
Dependent Claim
49 words
The method of claim 1 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 175 and the total molecular weight of the compound is approximately 8400.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the angioplasty procedure is balloon angioplasty.
Claim 6
Dependent Claim
11 words
The method of claim 1 wherein the angioplasty procedure is endarectomy.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein the surface-active copolymer is injected before the angioplasty procedure is performed.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the surface-active copolymer is infused during the angioplasty procedure.
Claim 9
Dependent Claim
15 words
The method of claim 1 wherein the surface-active copolymer is infused after the angioplasty procedure.
Claim 10
Dependent Claim
19 words
The method of claim 8 wherein the surface-active copolymer is infused up to 72 hours after the angioplasty procedure.
Claim 11
Dependent Claim
14 words
The method of claim 1 further comprising administering an antiocoagulant with the surface-active copolymer.
Claim 12
Dependent Claim
21 words
The method of claim 10 wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 13
Independent Claim
107 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting intravenously into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 14
Independent Claim
107 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting intravenously into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 15
Dependent Claim
75 words
The method of claim 12 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight by approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 16
Dependent Claim
49 words
The method of claim 12 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 17
Dependent Claim
12 words
The method of claim 12 wherein the angioplasty procedure is balloon angioplasty.
Claim 18
Dependent Claim
11 words
The method of claim 12 wherein the angioplasty procedure is endarectomy.
Claim 19
Dependent Claim
17 words
The method of claim 12 wherein the surface-active copolymer is injected before the angioplasty procedure is performed.
Claim 20
Dependent Claim
15 words
The method of claim 12 wherein the surface-active copolymer is infused during the angioplasty procedure.
Claim 21
Dependent Claim
15 words
The method of claim 12 wherein the surface-active copolymer is infused after the angiplasty procedure.
Claim 22
Dependent Claim
19 words
The method of claim 19 wherein the surface-active copolymer is infused up to 72 hours after the angioplasty procedure.
Claim 23
Dependent Claim
15 words
The method of claim 12 further comprising administering an anticoagulant agent with the surface-active copolymer.
Claim 24
Dependent Claim
21 words
The method of claim 21 wherein the anticoagulant is selected from the group consisting of heparin and low molecular weight heparin.
Claim 25
Independent Claim
107 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting intramuscularly into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 26
Independent Claim
107 words
A method of preventing tissue damage associated with an angioplasty procedure in an animal or human, comprising the step of injecting intramuscularly into the animal or human undergoing the angioplasty procedure a solution of an effective amount of a surface-active copolymer of the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 27
Dependent Claim
75 words
The method of claim 23 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes approximately 50% to 90% by weight of the copolymer.
Claim 28
Dependent Claim
49 words
The method of claim 23 wherein said surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 29
Dependent Claim
12 words
The method of claim 23 wherein the angioplasty procedure is balloon angioplasty.
Claim 30
Dependent Claim
11 words
The method of claim 23 wherein the angioplasty procedure is endarectomy.
Claim 31
Dependent Claim
17 words
The method of claim 23 wherein the surface-active copolymer is injected before the angioplasty procedure is performed.
Claim 32
Dependent Claim
15 words
The method of claim 23 wherein the surface-active copolymer is infused during the angioplasty procedure.
Claim 33
Dependent Claim
15 words
The method of claim 23 wherein the surface-active copolymer is infused after the angioplasty procedure.
Claim 34
Dependent Claim
19 words
The method of claim 30 wherein the surface-active copolymer is infused up to 72 hours after the angioplasty procedure.
Claim 35
Dependent Claim
9 words
The method of claim 23 further comprising an anticoagulant.
Claim 36
Dependent Claim
21 words
The method of claim 32 wherein the anticoagulant is selected from the group consisting of heparin and low molecular weith heparin.
References Cited (Backward Citations)
US2674619A
Cited
US2854378A
Cited
US3089818A
Cited
US3140232A
Cited
US3740421A
Cited
US3450502A
Cited
US3641240A
Cited
US3577522A
Cited
US3590125A
Cited
US3980772A
Cited
US3867521A
Cited
US3956259A
Cited
US4073886A
Cited
US4179337A
Cited
JPS525094A
Cited
US4100271A
Cited
US4305922A
Cited
US4186253A
Cited
US4395393A
Cited
US4407790A
Cited
US4609546A
Cited
SU1183112A1
Cited
US4600652A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-05-20 | 1994-11-19 | 1995-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-20 | 1998-11-19 | 1999-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-20 | 2002-11-19 | 2003-05-21 | $7700.00 | Window Closed / Lapsed |