Patent US4886870A successfully refreshed from Google Patents.
US4886870A
Expired / Lapsed
US
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Bioerodible articles useful as implants and prostheses having predictable degradation rates
Assignee: Massachusetts Institute of Technology
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Filing: 1985-02-15
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Granted: 1989-12-12
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Expires: 2005-02-15
Abstract
Abstract A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.
Inventors
- 👤 Patricia D'Amore
- 👤 Kam W. Leong
- 👤 Robert S. Langer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:07
CPC Classifications
C; C08; C08G; C08G67/00; C08G67/04; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/58
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
70 words
An article useful for implantation or otherwise placed in or on the body, comprising a biocompatible, bioerodible, hydrophobic polyanhydride composition of the formula ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being purified and characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading at predictable, constant rates by hydrolysis into non-toxic residues after introduction in vivo.
Claim 2
Dependent Claim
70 words
An article useful for implantation or otherwise placed in or on the body, comprising a biocompatible, bioerodible, hydrophobic polyanhydride composition of the formula ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being purified and characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading at predictable, constant rates by hydrolysis into non-toxic residues after introduction in vivo.
Claim 3
Dependent Claim
19 words
The article as recited in claim 1 wherein said R group is a hydrocarbon comprising from 2-16 carbon atoms.
Claim 4
Dependent Claim
13 words
The article as recited in claim 1 wherein said R group is ##STR9##
Claim 5
Dependent Claim
26 words
The article as recited in claim 1 where in the R group is ##STR10## wherein x is not less than 2 and not more than 16.
Claim 6
Dependent Claim
19 words
The article as recited in claim 1 wherein said R group is ##STR11## wherein x is at least 1.
Claim 7
Dependent Claim
25 words
The article as recited in claim 1 wherein said R group is ##STR12## wherein x is at least 1 and y is at least 1.
Claim 8
Dependent Claim
26 words
The article as recited in claim 1 wherein said R group is selected from the group consisting of ##STR13## wherein R' and R" are organic groups.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-11 | 1993-06-12 | 1993-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-11 | 1997-06-12 | 1997-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-11 | 2001-06-12 | 2001-12-12 | $7700.00 | Window Closed / Lapsed |