US3811444A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioerodible ocular device
Assignee: Alza Corp
•
Filing: 1972-12-27
•
Granted: 1974-05-21
•
Expires: 1992-12-27
Abstract
Abstract An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The insert comprises a drug formulation dispersed through a body of selected hydrophobic polycarboxylic acids which erode in the environment of the eye over a prolonged period of time to dispense the desired amount of drug.
Inventors
- 👤 J Heller
- 👤 R Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/0012; A61K9/0048; A61K9/0051
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
12 words
The ocular device defined in claim 1 wherein the R''s are hydrocarbons.
Claim 2
Dependent Claim
12 words
The ocular device defined in claim 1 wherein the R''s are oxyhydrocarbons.
Claim 3
Dependent Claim
14 words
The ocular device defined in claim 3 wherein the oxyhydrocarbon R''s contain ester groups.
Claim 4
Dependent Claim
14 words
The oCular device defined in claim 3 wherein the oxyhydrocarbon R''s contain ether groups.
Claim 5
Dependent Claim
14 words
The ocular device defined in claim 3 wherein the drug is an antiinflammatory drug.
Claim 6
Dependent Claim
68 words
The ocular device is defined in claim 1 wherein the hydrophobic poly(carboxylic acid) comprises a polymer of an acid selected from the group consisting of maleic acid, acrylic acid and lower alkyl acrylic acids of from four to six carbon atoms, in which from about 20 to about 70 percent of the acid groups have been esterified with an alkanol of from one to about 10 carbon atoms.
Claim 7
Dependent Claim
92 words
The ocular device defined in claim 1 wherein the hydrophobic poly(carboxylic acid) comprises a copolymer of an acid selected from the group consisting of maleic acid, acrylic acid, and lower alkyl acrylic acids of from four to about six carbon atoms, with a copolymerizable olefinically unsaturated material selected from the group consisting of ethylene, propylene, butadiene, isoprene and styrene and the lower alkyl vinyl ethers, in which from about 20 to about 90 percent of the acid groups have been esterified with an alkanol of from one to about 10 carbon atoms.
Claim 8
Dependent Claim
14 words
The ocular device defined by claim 8 wherein the drug is an antiinflammatory drug.
Claim 9
Dependent Claim
70 words
The ocular device defined by claim 1 wherein the hydrophobic poly(carboxylic acid) comprises a hydrophobic partially esterified copolymer of acrylic acid, methacrylic acid or maleic acid with from 0.2 to 1.5 moles, per mole of acid, of ethylene or lower one to four carbon alkyl vinyl ether having from about 40 to 60 percent of its total carboxyl groups esterified with lower alkanol of from three to 10 carbon atoms.
Claim 10
Dependent Claim
26 words
The ocular device defined by claim 10 wherein the drug comprises a drug selected from the group consisting of pilocarpine, hydrocortisone alcohol and acetate and chloroamphenicol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-05-20 | 1977-11-19 | 1978-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-05-20 | 1981-11-19 | 1982-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-05-20 | 1985-11-19 | 1986-05-21 | $7700.00 | Window Closed / Lapsed |