US3625214A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug-delivery device
Assignee: Alza Corp
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Filing: 1970-05-18
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Granted: 1971-12-07
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Expires: 1990-05-18
Abstract
Abstract A drug-delivery device for prolongedly delivering drugs to patients according to any predetermined time release profile, e.g., increasing, decreasing, constant, pulsing, sinusoidal, and like patterns of release, is fabricated by applying a drug coating of varying or uniform thickness to a relatively drugimpermeable film soluble in body fluids and thence rolling said coated film about itself in spiral or ''''jellyroll'''' fashion. Upon administration to the body, the outermost extremities of the film gradually erode at a predetermined rate in body fluids thus exposing coextensive extremities of the drug coating, also soluble in body fluids, and drug is released to the tissues of the body. Suitable design of the drug coating along the spiral, e.g., of varying thickness, etc. provides for the aforesaid release patterns as the device disintegrates.
Inventors
- 👤 Takeru Higuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:42
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61D; A61D7/00; A61K9/2086; A61K9/70; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
51 words
A drug-delivery device for prolongedly delivering drugs according to any predetermined time release profile comprised of a spirally rolled substrate, said substrate being comprised of a relatively drug impermeable, flexible film erodible in body fluids and being coated with a drug-containing matrix composition, which matrix itself is erodible in body fluids.
Claim 2
Dependent Claim
51 words
A drug-delivery device for prolongedly delivering drugs according to any predetermined time release profile comprised of a spirally rolled substrate, said substrate being comprised of a relatively drug impermeable, flexible film erodible in body fluids and being coated with a drug-containing matrix composition, which matrix itself is erodible in body fluids.
Claim 3
Dependent Claim
22 words
The drug-delivery device as defined by claim 1, wherein the matrix composition is more rapidly erodible in body fluids than said film.
Claim 4
Dependent Claim
18 words
The drug-delivery device as defined by claim 1, wherein the drug is uniformly distributed throughout the matrix composition.
Claim 5
Dependent Claim
19 words
The drug-delivery device as defined by claim 3, wherein the drug coating is of constant thickness along the spiral.
Claim 6
Dependent Claim
16 words
The drug-delivery device as defined by claim 3, wherein the drug coating is of varying thickness.
Claim 7
Dependent Claim
19 words
The drug-delivery device as defined by claim 3, wherein the thickness of the drug coating increases along the spiral.
Claim 8
Dependent Claim
19 words
The drug-delivery device as defined by claim 3, wherein the thickness of the drug coating decreases along the spiral.
Claim 9
Dependent Claim
19 words
The drug-delivery device as defined by claim 3, wherein the drug coating is of sinusoidal thickness along the spiral.
Claim 10
Dependent Claim
23 words
The drug-delivery device as defined by claim 5, wherein the film is comprised of a polymeric material which slowly dissolves in body fluids.
Claim 11
Dependent Claim
21 words
The drug-delivery device as defined by claim 3, wherein the film is comprised of polymeric material which hydrolyzes in body fluids.
Claim 12
Dependent Claim
25 words
The drug-delivery device as defined by claim 3, wherein the membrane is comprised of polymeric material which is cleaved by enzymes present in body fluids.
Claim 13
Dependent Claim
17 words
The drug-delivery device as defined by claim 1 bearing an external coating of said drug-containing matrix composition.
Claim 14
Independent Claim
64 words
A device for prolongedly delivering active ingredient to a given fluid environment according to any predetermined time release profile comprised of a spirally rolled substrate said substrate being comprised of a relatively active ingredient impermeable, flexible film erodible in a given fluid environment, said film being coated with an active ingredient containing matrix composition, which matrix itself is erodible in said given fluid environment.
Claim 15
Independent Claim
64 words
A device for prolongedly delivering active ingredient to a given fluid environment according to any predetermined time release profile comprised of a spirally rolled substrate said substrate being comprised of a relatively active ingredient impermeable, flexible film erodible in a given fluid environment, said film being coated with an active ingredient containing matrix composition, which matrix itself is erodible in said given fluid environment.
Claim 16
Dependent Claim
29 words
The method of prolongedly delivering drug to a patient according to any predetermined time release profile comprising administering to said patient the drug-delivery device as defined by claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-12-06 | 1975-06-07 | 1975-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-12-06 | 1979-06-07 | 1979-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-12-06 | 1983-06-07 | 1983-12-07 | $7700.00 | Window Closed / Lapsed |