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Patent US4872867A successfully refreshed from Google Patents.
US4872867A
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US
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Compositions having antithrombogenic properties and blood contact medical devices using the same
Assignee: Ube Corp
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Filing: 1989-02-28
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Granted: 1989-10-10
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Expires: 2009-02-28
Abstract
Abstract This invention is a composition having anti-thrombogenic properties, comprising as essential constituent components a polyurethane or polyurethane urea containing polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromolecules, and a silicon-containing compound capable of forming polysiloxane while crosslinking; and a blood contact medical device having such a composition on blood contact surfaces. According to this invention, it is possible to provide on blood contact surfaces a hydrophilic polymer which is excellent in dynamic properties and very rich in the antithrombogenic properties, and the invention can be greatly contributory in the field of blood contact medical devices.
Inventors
- 👤 Yasushi Joh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:13
CPC Classifications
C; C08; C08L; C08L75/00; C08L75/04; C08L75/08; A; A61; A61L; A61L33/00; A61L33/06; A61L33/062; C08G; C08G2270/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
98 words
An antithrombogenic material having an interpenetrating polymer network which comprises (1) a polyether type polyurethane or polyurethane urea containing in its main chain a segment comprising polytetramethylene oxide; (2) a water soluble polymer, a water swellable polymer or a combination thereof; and (3) a room temerpature cross-linking type silane coupling agent capable of being activated by water and induced condensation polymerization with crosslinking which is crosslinked to form a hydrophobic highly crosslinked polysiloxane network in which network the polyether type polyurethane or polyurethane urea, and the water soluble polymer, the water swellable polymer or combination thereof, are entangled.
Claim 2
Dependent Claim
98 words
An antithrombogenic material having an interpenetrating polymer network which comprises (1) a polyether type polyurethane or polyurethane urea containing in its main chain a segment comprising polytetramethylene oxide; (2) a water soluble polymer, a water swellable polymer or a combination thereof; and (3) a room temerpature cross-linking type silane coupling agent capable of being activated by water and induced condensation polymerization with crosslinking which is crosslinked to form a hydrophobic highly crosslinked polysiloxane network in which network the polyether type polyurethane or polyurethane urea, and the water soluble polymer, the water swellable polymer or combination thereof, are entangled.
Claim 3
Dependent Claim
38 words
The composition having antithrombogenic properites as claimed in claim 1, wherein said polymer is a macromolecular compound containing in its backbone, polyalkylene oxide wherein the carbon atom number of alkylene is 2 or 3 or 2 and 3.
Claim 4
Dependent Claim
32 words
The composition having antithrombogenic properties as claimed in claim 2, wherein the macromolecular compound containing in its main chain said polyalkylene oxide is a polyether polyurethane comprising polyethylene oxide as a segment.
Claim 5
Dependent Claim
19 words
The composition having antithrombogenic properties as claimed in claim 1, wherein the said polymer is a polydimethylsiloxane/polyethylene glycol copolymer.
Claim 6
Dependent Claim
72 words
The composition having antithrombogenic properties as claimed in claim 1, wherein the second component is at least one selected from polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acid or a salt thereof, polyhydroxyethyl acrylic acid or a salt thereof, atelo collagen, water soluble gelatin, chondroitin sulfuric acid or a salt thereof, hyaluronic acid, alginic acid, water soluble or, oxydized starch (dialdehyde starch, diacetone acrylamide, 2-acrylamide-2-methylpropane sulfonic acid or a salt thereof, and soluble heparin.
Claim 7
Dependent Claim
25 words
The composition having antithrombogenic properties as claimed in claim 1, wherein the silicon-coupling agent is at least one selected from methyltriethoxysilane, methyltriacetoxysilane, tetramethoxysilane and tetraacetoxysilane.
Claim 8
Dependent Claim
41 words
A blood contact medical device characterized in that it comprises a blood contact surface constituted of a polyurethane or polyurethane urea having polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromolecules, and a polysiloxane having crosslinked structure.
Claim 9
Dependent Claim
41 words
A blood contact medical device characterized in that it comprises a blood contact surface constituted of a polyurethane or polyurethane urea having polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromolecules, and a polysiloxane having crosslinked structure.
Claim 10
Dependent Claim
43 words
The composition having antithrombogenic properites as claimed in claim 1 wherein said silane coupling agent contains Si-OCOR or Si-OR wherein R is CH 3 , C 2 H 5 , C 3 H 7 or C 4 H 9 , as functional groups.
Claim 11
Dependent Claim
26 words
The composition having antithrombogenic properties as claimed in claim 1 wherein said silane coupling agent contains SiOX or SiX wherein X is halogen, as functional group.
Claim 12
Dependent Claim
16 words
The compositon having antithrombogenic properties as claimed in claim 9 wherein X is chlorine or bromine.
Claim 13
Dependent Claim
41 words
The composition having antithrombogneic properties as claimed in claim 1 wherein said silane coupling agent contains Si-NR 2 wherein R is CH 3 , C 2 H 5 , C 3 H 7 or C 4 H 9 as functional groups.
Claim 14
Dependent Claim
15 words
The composition of claim 5 wherein the coupling agent is methyltriethoxysilane, methyltriacetoxysilane, tetramethoxysilane or tetraacetoxysilane.
Claim 15
Dependent Claim
12 words
The composition of claim 12 wherein said polyether type polyurethane is used.
Claim 16
Dependent Claim
11 words
The composition of claim 12 wherein said polyurethane urea is used.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-09 | 1993-04-10 | 1993-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-09 | 1997-04-10 | 1997-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-09 | 2001-04-10 | 2001-10-10 | $7700.00 | Window Closed / Lapsed |