Patent US4863732A successfully refreshed from Google Patents.
US4863732A
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Injectable composition for inductive bone repair
Assignee: Neucoll Inc
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Filing: 1987-12-16
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Granted: 1989-09-05
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Expires: 2007-12-16
Abstract
Abstract Aqueous suspensions of fibrillar atelopeptide collagen and osteogenic factor are effective injectable preparations for the repair of bone defects. Processes for the production of such preparations are described.
Inventors
- 👤 Ranga Nathan
- 👤 Andrea Thompson
- 👤 Saeid Seyedin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 08:21
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/24; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2400/00; A61L2400/06
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
41 words
An injectable bone growth-inducing composition comprising an injectable aqueous suspension of fibrillar atelopeptide collagen and at least partially purified osteogenic factor, wherein the fibrillar atelopeptide collagen and the at least partially purified osteogenic factor are in the form of a coprecipitate.
Claim 2
Dependent Claim
41 words
An injectable bone growth-inducing composition comprising an injectable aqueous suspension of fibrillar atelopeptide collagen and at least partially purified osteogenic factor, wherein the fibrillar atelopeptide collagen and the at least partially purified osteogenic factor are in the form of a coprecipitate.
Claim 3
Dependent Claim
21 words
The composition of claim 1 wherein the concentration of collagen is in the range of about 5 to about 65 mg/ml.
Claim 4
Dependent Claim
26 words
The composition of claim 2 wherein the weight ratio of collagen to osteogenic factor in the coprecipitate is in the range of about 5:1 to 300:1.
Claim 5
Dependent Claim
17 words
The composition of claim 4 wherein the osteogenic factor is coprecipitated from an acidic demineralized bone extract.
Claim 6
Dependent Claim
31 words
A method of inducing bone growth at a predetermined site within the body of a living mammalian individual comprising injecting the composition of claim 1 into said individual at said site.
Claim 7
Dependent Claim
32 words
A method of inducing bone growth at a predetermined determined site within the body of a living mammalian individual comprising injecting the composition of claim 2 into said individual at said site.
Claim 8
Dependent Claim
31 words
A method of inducing bone growth at a predetermined site within the body of a living mammalian individual comprising injecting the composition of claim 3 into said individual at said site.
Claim 9
Dependent Claim
31 words
A method of inducing bone growth at a predetermined site within the body of a living mammalian individual comprising injecting the composition of claim 4 into said individual at said site.
Claim 10
Dependent Claim
11 words
The method of claim 5 wherein the individual is a human.
Claim 11
Dependent Claim
66 words
A process for making the composition of claim 4 comprising the steps of: (a) providing an acidic, aqueous solution of atelopeptide collagen and osteogenic factor; (b) coprecipitating the atelopeptide collagen and osteogenic factor by increasing the pH of the solution; and (c) adjusting, if necessary, the concentration of the coprecipitate in the resulting suspension to about 5 to about 65 mg/ml, based on the atelopeptide collagen.
Claim 12
Dependent Claim
16 words
The process of claim 10 wherein the osteogenic factor is present as a demineralized bone extract.
Claim 13
Dependent Claim
24 words
The process of claim 11 wherein the weight ratio of atelopeptide collagen to demineralized bone extract in the solution is about 5:1 to 300:1.
Claim 14
Dependent Claim
19 words
The process of claim 10 wherein the pH of the solution is increased to about 6.5 to about 8.5.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |