Patent US4837285A successfully refreshed from Google Patents.
US4837285A
Expired / Lapsed
US
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Collagen matrix beads for soft tissue repair
Assignee: Medimatrix Inc
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Filing: 1987-09-08
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Granted: 1989-06-06
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Expires: 2007-09-08
Abstract
Abstract Collagen-based compositions for augmenting soft tissue, wound dressings, implants, injectable formulations or other drug delivery systems, comprising resorbable collagen matrix beads, the beads having an average pore size of from 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the collagen matrix being sufficiently open to stimulate cellular ingrowth therethrough and yet sufficiently stiff and non-compressible to fill and protect a wound, and the formulation being sufficiently moisture and gas permeable to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.
Inventors
- 👤 Richard A. Berg
- 👤 Frederick H. Silver
- 👤 James M. Pachence
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:00
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/44; A61L15/64; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/58; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/232; A61L2300/252; A61L2300/40; A61L2300/412; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
113 words
A wound dressing or implant comprising resorbable, porous collagen matrix beads having particle sizes of from about 100 to 4000 microns, the beads having an average pore size of from about 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix and being stiff and non-compressible to a degree sufficient to fill and protect a wound, the dressing or implant having a degree of moisture and gas permeability sufficient to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.
Claim 2
Dependent Claim
113 words
A wound dressing or implant comprising resorbable, porous collagen matrix beads having particle sizes of from about 100 to 4000 microns, the beads having an average pore size of from about 50 to 350 microns, and the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix and being stiff and non-compressible to a degree sufficient to fill and protect a wound, the dressing or implant having a degree of moisture and gas permeability sufficient to prevent liquid pooling on a wound and to permit sufficient oxygen diffusion for promoting wound healing.
Claim 3
Dependent Claim
20 words
The wound dressing of claim 1 wherein the collagen matrix beads are prepared from Type I or Type III collagen.
Claim 4
Dependent Claim
19 words
The wound dressing of claim 1 wherein the collagen matrix beads are in the form of a dry powder.
Claim 5
Dependent Claim
53 words
The wound dressing of claim 1 wherein the collagen matrix has a pore volume of from 80 to 99% by volume, and the matrix is constituted of fibers having a thickness of from 5 to 35 microns and has a stiffness of from 10 3 N/m 2 to 10 5 N/m 2 .
Claim 6
Dependent Claim
14 words
The wound dressing of claim 1 further comprising a macromolecule for promoting tissue ingrowth.
Claim 7
Dependent Claim
17 words
The wound dressing of claim 5 wherein the macromolecule is hyaluronic acid or fibronectin, or mixtures thereof.
Claim 8
Dependent Claim
21 words
The wound dressing of claim 5, wherein the macromolecule is transforming growth factor beta, platelet-derived growth factor, or a mixture thereof.
Claim 9
Dependent Claim
100 words
A compostion for injection into a wound site in mammals for promoting soft tissue augmentation, comprising a suspension of resorbable, porous native collagen matrix beads having particle sizes of about 100 to 4000 microns in an aqueous medium, the beads having an average pore size of 50 to 350 microns, the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix beads forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix, and being stiff and non-compressible to a degree sufficient to conform to the tissue to be repaired.
Claim 10
Dependent Claim
100 words
A compostion for injection into a wound site in mammals for promoting soft tissue augmentation, comprising a suspension of resorbable, porous native collagen matrix beads having particle sizes of about 100 to 4000 microns in an aqueous medium, the beads having an average pore size of 50 to 350 microns, the collagen comprising from 1 to 30% by volume of the beads, the porous collagen matrix beads forming a skeleton providing a volume sufficient for cells to attach and grow into the matrix, and being stiff and non-compressible to a degree sufficient to conform to the tissue to be repaired.
Claim 11
Dependent Claim
24 words
The composition of claim 8, wherein the suspension comprises the collagen matrix beads in an aqueous solution of a macromolecule for promoting tissue ingrowth.
Claim 12
Dependent Claim
32 words
The composition of claim 8, wherein the suspension comprises collagen matrix beads in admixture with an aqueous solution of transforming growth factor beta, platelet-derived growth factor, hyaluronic acid, fibronectin or mixtures thereof.
Claim 13
Dependent Claim
50 words
The composition of claim 8, wherein the collagen matrix has a pore volume of from 80 to 99% by volume, and the matrix is constituted of fibers having a thickness of from 5 to 35 microns and has a stiffness of from 10 3 to 10 5 N/m 2 .
Claim 14
Dependent Claim
22 words
A method for augmenting wound healing or soft tissue repair in mammals, comprising topically applying or implanting the composition of claim 1.
Claim 15
Dependent Claim
20 words
A method for augmenting soft tissue repair in mammals, comprising injecting the composition of claim 8 subcutaneously into a patient.
Claim 16
Dependent Claim
23 words
A wound dressing or implant as set forth in claim 1, wherein said beads have partizle sizes from about 300 to 500 microns.
Claim 17
Dependent Claim
21 words
A composition as set forth in claim 1, wherein said beads have particle sizes of from about 300 to 500 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-05 | 1992-12-05 | 1993-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-05 | 1996-12-05 | 1997-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-05 | 2000-12-05 | 2001-06-06 | $7700.00 | Window Closed / Lapsed |