US4409332A
Expired / Lapsed
US
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Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
Assignee: Isotis Orthobiologics Inc
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Filing: 1982-01-12
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Granted: 1983-10-11
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Expires: 2002-01-12
Abstract
Abstract Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements including wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural durability and stabilization of the anti-inflammatory properties of the material are enhanced by crosslinking with glutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen conjugate prior to in-vivo use.
Inventors
- 👤 Steven R. Jefferies
- 👤 James L. Gutmann
- 👤 Barry M. Heatfield
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063; A61K47/00; A61K47/30; A61K47/42; A61L; A61L15/00; A61L15/16; A61L15/38; A61L17/00; A61L17/06; A61L17/08; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C; C12; C12N; C12N11/00; C12N11/02; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
19 words
An inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
Claim 2
Dependent Claim
19 words
An inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
Claim 3
Dependent Claim
26 words
An article of manufacture consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
Claim 4
Dependent Claim
26 words
An article of manufacture consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
Claim 5
Dependent Claim
27 words
The polymeric complex of claim 1 further including a crosslinking, non-inflammatory inducing amount of glutaraldehyde as a crosslinking agent to confer physical integrity to the polymeric complex.
Claim 6
Dependent Claim
16 words
An in vivo implantable membrane made of the polymeric collagen-phosphatase conjugate of claim 1 or 3.
Claim 7
Dependent Claim
16 words
A surgical gut suture material made of the polymeric collagen-phosphatase conjugate of claim 1 or 3.
Claim 8
Dependent Claim
18 words
A biocompatible, in vivo-injectable gel consisting essentially of the polymeric collagen phosphate conjugate of claim 1 or 3.
Claim 9
Dependent Claim
19 words
A biocompatible gel consisting essentially of calcium hydroxide and the polymeric collagen phosphatase conjugate of claim 1 or 3.
Claim 10
Dependent Claim
48 words
A drug delivery support consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with a soluble alkaline phosphatase and at least one drug substance compatible with and adapted to separate from said conjugate over a period of several days.
Claim 11
Dependent Claim
48 words
A drug delivery support consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with a soluble alkaline phosphatase and at least one drug substance compatible with and adapted to separate from said conjugate over a period of several days.
Claim 12
Independent Claim
28 words
A method of forming a collagen-phosphatase conjugate comprising treating a collagen matrix with a solution of soluble alkaline phosphatase until an inert, non-inflammatory a collagen-phosphatase conjugate is formed.
Claim 13
Independent Claim
28 words
A method of forming a collagen-phosphatase conjugate comprising treating a collagen matrix with a solution of soluble alkaline phosphatase until an inert, non-inflammatory a collagen-phosphatase conjugate is formed.
Claim 14
Dependent Claim
14 words
The method of claim 9 wherein the collagen is crosslinked prior to said treatment.
Claim 15
Dependent Claim
22 words
The method of claim 9 including the additional step of crosslinking the thus formed collagen-phosphatase conjugate with a crosslinking amount of glutaraldehyde.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-10 | 1987-04-11 | 1987-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-10 | 1991-04-11 | 1991-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-10 | 1995-04-11 | 1995-10-11 | $7700.00 | Window Closed / Lapsed |