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US4748254A
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Mixed carboxylato platinum (II) complexes
Assignee: Institut Obschei I Neorganicheskoi Khimii Imeni Ns Kurnakova Akademii Nauk Sssr
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Filing: 1984-01-23
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Granted: 1988-05-31
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Expires: 2004-01-23
Abstract
Abstract Novel platinum(II) carboxylatocomplexes of the following general formula: ##STR1## wherein R is tetrahydrofurfuryl or cyclo-C n R" 2n-1 , R" is H, an alkyl, hydroxyl, n=3-6; R' is --CH 2 --, --CH 2 --CH 2 --, --CH(OH)--, --CH(OH)--CH 2 --, --CH(OH)--CH(OH)--. These compounds possess a clearly pronounced antitumor activity and are readily soluble in water. A process for preparing these compounds comprises reacting K [PtCl 3 NH 3 ] with KI, followed by treatment of the reaction mixture with tetrahydrofurfurylamine or an alicyclic amine and treatment of the resulting mixture of complexes with a silver salt of the formula: Ag 2 (OOC--R'--COO), wherein R' is as identified above.
Inventors
- 👤 Petr A. Cheltsov-Bebutov
- 👤 Alexandr N. Kravchenko
- 👤 Robert N. Schelokov
- 👤 Alexandra L. Konovalova
- 👤 Mikhail A. Presnov
- 👤 Viktor B. Ivanov
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:57
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
43 words
Platinum(II) carboxylatocomplexes of the formula: ##STR7## wherein R is tetrahydrofurfuryl or a cyclo-C n R" 2n-1 , each R" is independently H, an alkyl, or hydroxyl, n=3-6, R' is --CH 2 --, --CH 2 --CH 2 --, CH(OH)--, --CH(OH)--CH 2 --, or --CH(OH)--CH(OH)--.
Claim 2
Dependent Claim
43 words
Platinum(II) carboxylatocomplexes of the formula: ##STR7## wherein R is tetrahydrofurfuryl or a cyclo-C n R" 2n-1 , each R" is independently H, an alkyl, or hydroxyl, n=3-6, R' is --CH 2 --, --CH 2 --CH 2 --, CH(OH)--, --CH(OH)--CH 2 --, or --CH(OH)--CH(OH)--.
Claim 3
Dependent Claim
26 words
A platinum(II) carboxylatocomplex according to claim 1, characterized in that in the general formula R is cyclo-C 5 H 9 and R' is --CH(OH)--CH 2 --.
Claim 4
Dependent Claim
22 words
A platinum(II) carboxylatocomplex according to claim 1, characterized in that in the formula R is ##STR8## and R' is --CH(OH)--CH 2 --.
Claim 5
Dependent Claim
25 words
A platinum(II) carboxylatocomplex according to claim 1, characterized in that in the formula R is cyclo-C 5 H 9 and R' is --CH 2 --.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-31 | 1991-11-30 | 1992-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-31 | 1995-11-30 | 1996-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-31 | 1999-11-30 | 2000-05-31 | $7700.00 | Window Closed / Lapsed |